Nature Search

Superconductivity in an insulator

The superconductor–insulator phase transition is a quantum phenomenon that reveals a competition between the superconducting phase order and charge localization. Now, microwave spectroscopy is shown to be a promising approach to investigate this effect in controllable one-dimensional Josephson arrays.

Alexander D. Mirlin
Ivan V. Protopopov
News & Views24 Jun 2019
Nature Physics

Volume: 15, P: 880-881
Ion-conducting and gating molecular mechanisms of channelrhodopsin revealed by true-atomic-resolution structures of open and closed states

Channelrhodopsins (ChRs) are primary tools for precise optical control over living cells. Structures of a viral ChR, OLPVR1, in closed (1.1 Å) and open (1.3 Å) states reveal the key details of its molecular mechanism.

Dmitrii Zabelskii
Sergey Bukhdruker
Valentin Gordeliy
Research09 Apr 2025
Nature Structural & Molecular Biology

Volume: 32, P: 1347-1357
The interplay of DNA repair context with target sequence predictably biases Cas9-generated mutations

Here the authors measure how the absence of certain DNA repair genes change the frequencies of unique mutational outcomes generated by Cas9 DSBs at synthetic target sequences in mouse embryonic stem cells: they use this to build predictive models of the mutagenic outcomes of Cas9 scission.

Ananth Pallaseni
Elin Madli Peets
Leopold Parts
ResearchOpen Access27 Nov 2024
Nature Communications

Volume: 15, P: 1-14
Overlay databank unlocks data-driven analyses of biomolecules for all

In this work, the authors report NMR lipids Databank to promote decentralised sharing of biomolecular molecular dynamics (MD) simulation data with an overlay design. Programmatic access enables analyses of rare phenomena and advances the training of machine learning models.

Anne M. Kiirikki
Hanne S. Antila
O. H. Samuli Ollila
ResearchOpen Access07 Feb 2024
Nature Communications

Volume: 15, P: 1-15
Comparison of uridine and N1-methylpseudouridine mRNA platforms in development of an Andes virus vaccine

Modified nucleosides are often used in mRNA vaccines and can affect protein expression and immunogenicity. Here, the authors compare M segment based Andes virus mRNA vaccines, either with regular uridine or N1-methylpseudouridine, and characterize immune response and protection in rodents.

Ivan V. Kuzmin
Ruben Soto Acosta
Alexander Bukreyev
ResearchOpen Access30 Jul 2024
Nature Communications

Volume: 15, P: 1-18
True-atomic-resolution insights into the structure and functional role of linear chains and low-barrier hydrogen bonds in proteins

High-resolution (≤1.2 Å) structures of functional states of bacteriorhodopsin reveal the molecular mechanism for generating a membrane proton electrochemical gradient, a key event of cell bioenergetics driving ATP synthesis.

Valentin Borshchevskiy
Kirill Kovalev
Valentin Gordeliy
Research28 Apr 2022
Nature Structural & Molecular Biology

Volume: 29, P: 440-450
Mechanisms of inward transmembrane proton translocation

Using structural, functional and spectroscopic investigations of a bacterial inward proton-pumping rhodopsin, Kovalev et al. reveal its molecular mechanism and show how proton wires mediate ion selectivity and direct proton transport through cell membrane.

Kirill Kovalev
Fedor Tsybrov
Valentin Gordeliy
Research29 Jun 2023
Nature Structural & Molecular Biology

Volume: 30, P: 970-979
Prediction of prime editing insertion efficiencies using sequence features and DNA repair determinants

Prime editing efficiency is affected by insertion sequence features, secondary structure and DNA repair context.

Jonas Koeppel
Juliane Weller
Leopold Parts
ResearchOpen Access16 Feb 2023
Nature Biotechnology

Volume: 41, P: 1446-1456
A compendium of uniformly processed human gene expression and splicing quantitative trait loci

The eQTL Catalogue provides uniform processing of 21 eQTL studies, allowing the identification of highly reproducible eQTLs affecting whole gene and transcript expression levels.

Nurlan Kerimov
James D. Hayhurst
Kaur Alasoo
ResearchOpen Access06 Sept 2021
Nature Genetics

Volume: 53, P: 1290-1299
A single intranasal dose of human parainfluenza virus type 3-vectored vaccine induces effective antibody and memory T cell response in the lungs and protects hamsters against SARS-CoV-2

Philipp A. Ilinykh
Sivakumar Periasamy
Alexander Bukreyev
ResearchOpen Access25 Apr 2022
npj Vaccines

Volume: 7, P: 1-16

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