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Showing 1–4 of 4 results
Advanced filters: Author: Ivan N. Zheludev Clear advanced filters

  • The frameshift stimulation element (FSE) of coronaviruses is an RNA structure that is required for balanced expression of viral proteins and is thus a promising drug target. A structure of the SARS-CoV-2 FSE serves as a guide for the development of antisense oligonucleotides that impair virus replication.

    • Kaiming Zhang
    • Ivan N. Zheludev
    • Rhiju Das
    Research
    Nature Structural & Molecular Biology
    Volume: 28, P: 747-754

  • RNA viruses are defined by linear RNA genomes encoding an RNA-dependent RNA polymerase, while viroid-like elements consist of small, single-stranded, circular RNA genomes that, in some cases, encode self-cleaving catalytic RNAs. Here, the authors identify over 20,000 candidate viroid-like elements, and show that infectious agents of fungi display hybrid features of viroid-like RNAs and RNA viruses.

    • Marco Forgia
    • Beatriz Navarro
    • Marcos de la Peña
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11

  • This study provides empirical evidence for the formation of vesicles from mixtures of single-chain amphiphiles under alkaline hydrothermal conditions, suggesting that such conditions favoured protocell formation at the origin of life.

    • Sean F. Jordan
    • Hanadi Rammu
    • Nick Lane
    Research
    Nature Ecology & Evolution
    Volume: 3, P: 1705-1714