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Showing 1–3 of 3 results
Advanced filters: Author: Ivan Zein Clear advanced filters

  • Our article summarizes the results of recent research on the use of soft nanoparticles for delivering nucleic acids to tumor cells for RNA-based therapy. The first part of the article describes advances in the development, as well as the advantages and disadvantages of using lipid nanocarriers, and the second part describes the same for polymeric nanocarriers. The third part presents data on ongoing preclinical and clinical trials of soft nanoparticles (June 2025).

    • Victoriya Zhogla
    • Viktar Abashkin
    • Xiangyang Shi
    Reviews
    Polymer Journal
    P: 1-23

  • Dedifferentiated liposarcomas (DDLPS) typically have dedifferentiated (DD) and well-differentiated (WD) components, although their cellular origins remain elusive. Here, the authors characterise primary DDLPS tumours using bulk and single-cell multi-omics and find adipocyte stem cells that could be a common ancestor of WD and DD components.

    • Nadège Gruel
    • Chloé Quignot
    • Sarah Watson
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Human induced pluripotent stem cell (iPSC) cells have been used to model disease in specific cell types. Here, the authors develop an automated long-term culturing platform of human iPSC neurons, astrocytes, and microglia and use it to model some cellular aspects of Alzheimer’s disease.

    • Reina Bassil
    • Kenneth Shields
    • Ben Chih
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-21