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Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Cognitive function is associated with health and important life outcomes. Here, the authors perform a genome-wide association study for general cognitive function in 300,486 individuals and identify genetic loci that implicate neural and cell developmental pathways in this trait.

Gail Davies
Max Lam
Ian J. Deary
ResearchOpen Access29 May 2018
Nature Communications

Volume: 9, P: 1-16
Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence

Meta-analysis of genome-wide association studies for cognitive ability identifies 190 new loci and implicates 939 new genes related to neurogenesis, neuron differentiation and synaptic structure.

Jeanne E. Savage
Philip R. Jansen
Danielle Posthuma
Research25 Jun 2018
Nature Genetics

Volume: 50, P: 912-919
Common genetic variants influence human subcortical brain structures

Genome-wide association studies are used to identify common genetic variants that affect the structure of selected subcortical regions of the human brain; their identification provides insight into the causes of variability in brain development and may help to determine mechanisms of neuropsychiatric dysfunction.

Derrek P. Hibar
Jason L. Stein
Sarah E. Medland
Research21 Jan 2015
Nature

Volume: 520, P: 224-229
Identification of common variants associated with human hippocampal and intracranial volumes

Paul Thompson and colleagues report a genome-wide association study for hippocampal, intracranial and total brain volume. They identify a locus at 12q24 associated with hippocampal volume and a locus at 12q14 associated with intracranial volume.

Jason L Stein
Sarah E Medland
Paul M Thompson
Research15 Apr 2012
Nature Genetics

Volume: 44, P: 552-561
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

The authors defined a roadmap for investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders. Their proof-of-concept study using the largest available common variant data sets for schizophrenia and volumes of several (mainly subcortical) brain structures did not find evidence of genetic overlap.

Barbara Franke
Jason L Stein
Patrick F Sullivan
Research01 Feb 2016
Nature Neuroscience

Volume: 19, P: 420-431
Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Gail Davies
Max Lam
Ian J. Deary
Amendments and CorrectionsOpen Access01 May 2019
Nature Communications

Volume: 10, P: 1-5
Identifying nootropic drug targets via large-scale cognitive GWAS and transcriptomics

Max Lam
Chia-Yen Chen
Todd Lencz
ResearchOpen Access25 May 2021
Neuropsychopharmacology

Volume: 46, P: 1788-1801
Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index

A Hinney
M Kesselmeier
J Hebebrand
Research17 May 2016
Molecular Psychiatry

Volume: 22, P: 192-201
A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling

Dong Li
Xiao Chang
Hakon Hakonarson
ResearchOpen Access19 Jun 2017
Scientific Reports

Volume: 7, P: 1-8
Erratum: A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling

Dong Li
Xiao Chang
Hakon Hakonarson
Amendments and CorrectionsOpen Access21 Aug 2017
Scientific Reports

Volume: 7, P: 1-4

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