Nature Search

Cross-dataset pan-cancer detection by correlating cell-free DNA fragment coverage with open chromatin sites across cell types

Fragmentation patterns of cell-free DNA are a promising biomarker source, however, correlations with different cancer types are heterogenous. Here, the authors develop LIONHEART to enable detection of 14+ cancer types from whole genome sequenced cell-free DNA.

Ludvig Renbo Olsen
Denis Odinokov
Søren Besenbacher
ResearchOpen Access21 Nov 2025
Nature Communications

Volume: 16, P: 1-12
Author Correction: Molecular correlates of cisplatin-based chemotherapy response in muscle invasive bladder cancer by integrated multi-omics analysis

Ann Taber
Emil Christensen
Lars Dyrskjøt
Amendments and CorrectionsOpen Access04 Apr 2022
Nature Communications

Volume: 13, P: 1
Comprehensive genomic characterization of early-stage bladder cancer

A genomic and transcriptomic analysis of nonmuscle-invasive bladder cancer identifies four molecular subtypes, and associates whole-genome duplication and immune exhaustion with tumor progression.

Frederik Prip
Philippe Lamy
Lars Dyrskjøt
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 115-125
Molecular correlates of cisplatin-based chemotherapy response in muscle invasive bladder cancer by integrated multi-omics analysis

There are currently only a few biomarkers to predict the response of muscle invasive bladder cancer to therapy. Here, the authors analyse 300 tumors using exome and RNA sequencing and find that tumors with a high degree of genomic instability and a non-basal/squamous gene expression subtype are most likely to respond to treatment.

Ann Taber
Emil Christensen
Lars Dyrskjøt
ResearchOpen Access25 Sept 2020
Nature Communications

Volume: 11, P: 1-15
An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer

Multiple molecular profiling methods are required to study urothelial non-muscle-invasive bladder cancer (NMIBC) due to its heterogeneity. Here the authors integrate multi-omics data of 834 NMIBC patients, identifying a molecular subgroup associated with multiple alterations and worse outcomes.

Sia Viborg Lindskrog
Frederik Prip
Lars Dyrskjøt
ResearchOpen Access16 Apr 2021
Nature Communications

Volume: 12, P: 1-18
Pervasive chromosomal instability and karyotype order in tumour evolution

Chromosomal instability enables the continuous selection of somatic copy number alterations, which are established as ordered events that often occur in parallel, throughout tumour evolution and metastasis.

Thomas B. K. Watkins
Emilia L. Lim
Charles Swanton
Research02 Sept 2020
Nature

Volume: 587, P: 126-132
Optimized targeted sequencing of cell-free plasma DNA from bladder cancer patients

Emil Christensen
Iver Nordentoft
Lars Dyrskjøt
ResearchOpen Access30 Jan 2018
Scientific Reports

Volume: 8, P: 1-11
Circulating tumour DNA and circulating tumour cells in bladder cancer — from discovery to clinical implementation

In this Review, the authors provide an overview of circulating tumour DNA and circulating tumour cells as potential biomarkers to provide therapeutic guidance and optimize disease surveillance in bladder cancer. Challenges associated with these biomarkers and future perspectives for clinical implementation are also discussed.

Sia V. Lindskrog
Trine Strandgaard
Lars Dyrskjøt
Reviews15 Apr 2025
Nature Reviews Urology

Volume: 22, P: 590-608
Discordant molecular subtype classification in the basal-squamous subtype of bladder tumors and matched lymph-node metastases

Gottfrid Sjödahl
Pontus Eriksson
Mattias Höglund
Research02 Jul 2018
Modern Pathology

Volume: 31, P: 1869-1881
Profiling of long non-coding RNAs identifies LINC00958 and LINC01296 as candidate oncogenes in bladder cancer

Anna Katharina Seitz
Lise Lotte Christensen
Lars Dyrskjøt
ResearchOpen Access24 Mar 2017
Scientific Reports

Volume: 7, P: 1-12
Altered gene expression and repressed markers of autophagy in skeletal muscle of insulin resistant patients with type 2 diabetes

Andreas Buch Møller
Ulla Kampmann
Niels Jessen
ResearchOpen Access02 Mar 2017
Scientific Reports

Volume: 7, P: 1-11
Comprehensive multiregional analysis of molecular heterogeneity in bladder cancer

Mathilde Borg Houlberg Thomsen
Iver Nordentoft
Lars Dyrskjøt
ResearchOpen Access15 Sept 2017
Scientific Reports

Volume: 7, P: 1-9
Widespread DNA hypomethylation and differential gene expression in Turner syndrome

Christian Trolle
Morten Muhlig Nielsen
Claus Højbjerg Gravholt
ResearchOpen Access30 Sept 2016
Scientific Reports

Volume: 6, P: 1-14

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