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Showing 1–6 of 6 results
Advanced filters: Author: Izumi Ohigashi Clear advanced filters

  • Thymic epithelial cells (TEC) are essential for the maturation of functional T cells, while thymus size is proportional to the overall output efficiency. Here the authors show, using transcriptome analyses, that mouse fetal TEC maintain a Myc-dependent genetic program to ensure a rapid increase in thymus size, and thereby expedited T cell generation.

    • Jennifer E. Cowan
    • Justin Malin
    • Avinash Bhandoola
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • Foxn1 is involved in thymic epithelial cell (TEC) and CD8+T cell development. Here the authors show this development requires Foxn1 binding proximal to, and inducing transcription of, the gene encoding β5t in cortical TECs.

    • Muhammad Myn Uddin
    • Izumi Ohigashi
    • Yousuke Takahama
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10

  • Although the importance of thymic epithelial cells (TEC) in thymus physiology is established, the development of functionally diverse TEC populations remains incompletely understood. Here, using fate-mapping experiments in the embryonic thymus, the authors identify keratin19+ multipotent progenitor cells that support medullary TEC diversity in adulthood.

    • Beth Lucas
    • Andrea J. White
    • Graham Anderson
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • Activated B cell enter germinal centers (GC) to become plasma cells and memory B cells. Here the authors show that some memory B cells recycle to GC via CCL-21 mediated chemotaxis to deliver antigens from the lymph node subcapsular sinus (SCS) to potentially contribute to affinity maturation and antigenic drift.

    • Yang Zhang
    • Laura Garcia-Ibanez
    • Kai-Michael Toellner
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Thymus is a unique environment hosting the development of many T cell subsets with distinct functions. Here the authors show that medullary thymic epithelial cells (mTEC) are functionally diverse, with LTβR signaling serving differential regulation of mTEC for specific control of multiple lineages of invariant natural killer T cells.

    • Beth Lucas
    • Andrea J. White
    • Graham Anderson
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • The generation of a diverse T cell repertoire depends on heterogeneous populations of thymic epithelial cells (TECs). Here, the authors explain how different subsets of TECs support and coordinate different stages of T cell development to ensure the selection of a functional and self-tolerant T cell repertoire.

    • Yousuke Takahama
    • Izumi Ohigashi
    • Graham Anderson
    Reviews
    Nature Reviews Immunology
    Volume: 17, P: 295-305