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Showing 1–6 of 6 results
Advanced filters: Author: Jérémie Gaillard Clear advanced filters

  • Molecular motors destroy a microtubule lattice as they walk on it, but it is now shown that a self-healing process incorporates new dimers in the damaged regions and prevents microtubule disassembly.

    • Sarah Triclin
    • Daisuke Inoue
    • Manuel Théry
    Research
    Nature Materials
    Volume: 20, P: 883-891

  • Microtubules vary their length by gaining and shedding tubulin dimers dynamically at both ends. But evidence now suggests that dimers may also be incorporated into the middle of the shaft—calling into question existing models of growth dynamics.

    • Laura Schaedel
    • Sarah Triclin
    • Karin John
    Research
    Nature Physics
    Volume: 15, P: 830-838

  • Cell polarity is marked by re-orientation of the centrosome, but the mechanisms governing centrosome polarization are poorly understood. Here Obino et al. show that in lymphocytes centrosome-associated Arp2/3 nucleates actin that tethers the centrosome to the nucleus; activation depletes Arp2/3 from the centrosome and frees it from the nucleus.

    • Dorian Obino
    • Francesca Farina
    • Ana-Maria Lennon-Duménil
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14

  • Experiments show that the progressive softening of microtubules under mechanical stress results from the enlargement of pre-existing structural defects, and that the incorporation of tubulin dimers can restore the microtubule’s initial stiffness.

    • Laura Schaedel
    • Karin John
    • Manuel Théry
    Research
    Nature Materials
    Volume: 14, P: 1156-1163

  • Théry and colleagues find that the centrosome can participate in actin-filament assembly in a manner that is mediated by WASH and Arp2/3 and requires the presence of pericentriolar material.

    • Francesca Farina
    • Jérémie Gaillard
    • Manuel Théry
    Research
    Nature Cell Biology
    Volume: 18, P: 65-75

  • Microtubules can self-repair in vitro in response to stress. Théry and colleagues now show that such repair can occur in cells, as free tubulin dimers can be incorporated into a damaged microtubule lattice to promote rescue events.

    • Charlotte Aumeier
    • Laura Schaedel
    • Manuel Théry
    Research
    Nature Cell Biology
    Volume: 18, P: 1054-1064