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Advanced filters: Author: Jérome Doss Clear advanced filters
  • Deregulation of the Phosphoinositide 3-kinase (PI3K) pathway is associated with metabolic flexibility leading to cancer poor prognosis. Here, the authors show that targeting both glutamine degradation and mTOR inhibition effectively kills PI3K-altered cancer cells in pre-clinical and clinical settings for T-cell acute lymphoblastic leukemia and solid cancer.

    • Guillaume P. Andrieu
    • Mathieu Simonin
    • Vahid Asnafi
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15