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Showing 1–8 of 8 results
Advanced filters: Author: Jürgen Soutschek Clear advanced filters

  • Recent work found that overexpression of short hairpin RNAs in cells could lead to mortality in mice, this was attributed to interference with the cellular machinery that makes miRNAs. This raised the issue of whether RNA interference-mediated silencing would be therapeutically possible. This paper shows that small interfering RNAs can be systemically administered and effectively suppress gene expression without compromising the activity of various liver miRNAs.

    • Matthias John
    • Rainer Constien
    • David Bumcrot
    Research
    Nature
    Volume: 449, P: 745-747

  • Systemically administered modified siRNAs can be used in monkeys to achieve long-lasting silencing of a gene — previously, this had been established only in mice.

    • Tracy S. Zimmermann
    • Amy C. H. Lee
    • Ian MacLachlan
    Research
    Nature
    Volume: 441, P: 111-114

  • Efforts to develop drugs that would prevent a primary tumor from spreading to new sites have been hampered by a lack of metastasis-specific targets. Working with a mouse model of breast cancer, Ma et al. show for the first time that metastasis formation can be substantially reduced by inhibition of a pro-metastatic microRNA.

    • Li Ma
    • Ferenc Reinhardt
    • Robert A Weinberg
    Research
    Nature Biotechnology
    Volume: 28, P: 341-347

  • Viral microRNAs have been shown to downregulate complementary viral mRNA targets and to bind to 3′ untranslated regions of host cell mRNAs to prevent their translation or induce their degradation. This paper shows that viral miRNAs can also function as orthologues of cellular miRNAs and downregulate the expression of cellular mRNAs via target sites that may be evolutionary conserved.

    • Eva Gottwein
    • Neelanjan Mukherjee
    • Bryan R. Cullen
    Research
    Nature
    Volume: 450, P: 1096-1099

  • MicroRNAs are expressed in a type of heart cell known as cardiomyocytes and their aberrant regulation was correlated with heart disease. This study looks at how miRNAs in other heart cells may contribute to disease. It is found that in cardiac fibroblasts, miR-21 is upregulated in diseased heart. This activates a signalling pathway that exacerbates cardiac disease. By using an RNA molecule directed against miR-21, it was possible to reverse these effects, demonstrating that therapeutic treatment to downregulate a microRNA can be effective in vivo.

    • Thomas Thum
    • Carina Gross
    • Stefan Engelhardt
    Research
    Nature
    Volume: 456, P: 980-984