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Showing 51–100 of 225 results

Advanced filters: Author: J A Engelman Clear advanced filters

Detergent structure in crystals of a bacterial photosynthetic reaction centre

M. Roth
A. Lewit-Bentley
D. Oesterhelt
Research24 Aug 1989
Nature

Volume: 340, P: 659-662
A consensus amino-acid sequence repeat in Torpedo and mammalian Ca²⁺-dependent membrane-binding proteins

Michael J. Geisow
Ulrich Fritsche
Tolu Johnson
Research01 Apr 1986
Nature

Volume: 320, P: 636-638
A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem

Karen A. Ketchum
William J. Joiner
Steve A. N. Goldstein
Research24 Aug 1995
Nature

Volume: 376, P: 690-695
Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome llq

L. Hashimoto
C. Habita
C. Julier
Research08 Sept 1994
Nature

Volume: 371, P: 161-164
A 110-ms pulsar, with negative period derivative, in the globular cluster M15

A. Wolszczan
S. R. Kulkarni
R. J. Dewey
Research09 Feb 1989
Nature

Volume: 337, P: 531-533
Association of constitutively activated hepatocyte growth factor receptor (Met) with resistance to a dual EGFR/Her2 inhibitor in non-small-cell lung cancer cells

S Agarwal
C Zerillo
D F Stern
ResearchOpen Access24 Feb 2009
British Journal of Cancer

Volume: 100, P: 941-949
Stabilization of the membrane protein bacteriorhodopsin to 140 °C in two-dimensional films

Yi Shen
Cyrus R. Safinya
Kenneth J. Rothschild
Research04 Nov 1993
Nature

Volume: 366, P: 48-50
An AIDS-related cytotoxic autoantibody reacts with a specific antigen on stimulated CD4⁺ T cells

Raphael B. Stricker
Thomas M. McHugh
Jay A. Levy
Research25 Jun 1987
Nature

Volume: 327, P: 710-713
H1047R phosphatidylinositol 3-kinase mutant enhances HER2-mediated transformation by heregulin production and activation of HER3

A Chakrabarty
B N Rexer
C L Arteaga
Research28 Jun 2010
Oncogene

Volume: 29, P: 5193-5203
Expression of β-globin by cancer cells promotes cell survival during blood-borne dissemination

Circulating tumour cells contribute to metastatic spread. Here the authors find that beta-chain of haemoglobin is overexpressed in those cells and protects them from oxidative stress, prolonging their survival in circulation and thereby increasing the likelihood of metastasis formation.

Yu Zheng
David T. Miyamoto
Daniel A. Haber
ResearchOpen Access09 Feb 2017
Nature Communications

Volume: 8, P: 1-12
Direct biochemical demonstration of two types of α-adrenoreceptor in rat brain

PETER J. MIACH
JEAN-PIERRE DAUSSE
PHILIPPE MEYER
Research03 Aug 1978
Nature

Volume: 274, P: 492-494
Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function

An unexpected octameric integrase architecture for the betaretrovirus mouse mammary tumour virus intasome.

Allison Ballandras-Colas
Monica Brown
Alan N. Engelman
Research17 Feb 2016
Nature

Volume: 530, P: 358-361
ABO Blood Groups, Secretor Status, and Intestinal Mucosal Concentrations of Alkaline Phosphatase

M. J. S. LANGMAN
A. CONSTANTINOPOULOS
I. A. D. BOUCHIER
Research02 Mar 1968
Nature

Volume: 217, P: 863-865
Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi

Claire M. Fraser
Sherwood Casjens
J. Craig Venter
Research01 Dec 1997
Nature

Volume: 390, P: 580-586
The output of the Etna volcano

G. WADGE
G. P. L. WALKER
J. E. GUEST
Research29 May 1975
Nature

Volume: 255, P: 385-387
Large sudden warming in the Southern Hemisphere

J. J. BARNETT
Research29 May 1975
Nature

Volume: 255, P: 387-389
Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima

Karen E. Nelson
Rebecca A. Clayton
Claire M. Fraser
Research27 May 1999
Nature

Volume: 399, P: 323-329
The complete genome sequence of the gastric pathogen Helicobacter pylori

Jean-F. Tomb
Owen White
J. Craig Venter
Research07 Aug 1997
Nature

Volume: 388, P: 539-547
Viral and host mediators of non-suppressible HIV-1 viremia

Understanding the heterogeneity of HIV infection, such as in persons with non-suppressible HIV-1 viremia despite adherence to antiretroviral treatment, is crucial to better tailor therapeutic interventions to abrogate HIV-1 persistence.

Abbas Mohammadi
Behzad Etemad
Jonathan Z. Li
ResearchOpen Access13 Nov 2023
Nature Medicine

Volume: 29, P: 3212-3223
Geomagnetic secular variation in Sicily and revised ages of historic lavas from Mount Etna

J. C. Tanguy
I. Bucur
J. F. C. Thompson
Research05 Dec 1985
Nature

Volume: 318, P: 453-455
Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

Therapy-resistant cancer cell states identified across diverse contexts are selectively vulnerable to ferroptotic cell death induced by inhibition of lipid peroxidase pathways converging on GPX4.

Vasanthi S. Viswanathan
Matthew J. Ryan
Stuart L. Schreiber
Research05 Jul 2017
Nature

Volume: 547, P: 453-457
Genetic architecture of cerebrospinal fluid and brain metabolite levels and the genetic colocalization of metabolites with human traits

Genome-wide association study of cerebrospinal fluid and brain metabolites highlights the unique genetic architecture of metabolite levels and metabolite–trait associations with brain-related phenotypes.

Ciyang Wang
Chengran Yang
Carlos Cruchaga
Research11 Nov 2024
Nature Genetics

Volume: 56, P: 2685-2695
Sleep Patterns in Hyperphenylalaninemia: A Lesson on Serotonin to be Learned from Phenylketonuria

F J Schulte
H J Kaiser
H G Lenard
Research01 Jun 1973
Pediatric Research

Volume: 7, P: 588-599
A landscape of response to drug combinations in non-small cell lung cancer

Combination of drugs within cancer treatment is a popular way to overcome resistance and increase efficacy. Here, the authors analyse over 5000 targeted agent combinations in non-small cell lung cancer to identify potentially effective drug strategies.

Nishanth Ulhas Nair
Patricia Greninger
Cyril H. Benes
ResearchOpen Access28 Jun 2023
Nature Communications

Volume: 14, P: 1-19
Genetics of secondarily homothallic basidiomycetes

F A Langton
T J Elliott
Research01 Aug 1980
Heredity

Volume: 45, P: 99-106
Cutaneous malignant melanoma in West Yorkshire: I. A prospective study of variables, survival and prognosis

J Eastwood
T G Baker
Research01 Nov 1983
British Journal of Cancer

Volume: 48, P: 645-655
Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75

Peter Cherepanov
Zhen-Yu J Sun
Alan Engelman
Research15 May 2005
Nature Structural & Molecular Biology

Volume: 12, P: 526-532
Phosphoinositide 3-OH kinase p85α and p110β are essential for androgen receptor transactivation and tumor progression in prostate cancers

Q Zhu
H Youn
B Li
Research31 Mar 2008
Oncogene

Volume: 27, P: 4569-4579
Use of arterial devascularization and cytotoxic drugs in 30 patients with the carcinoid syndrome

W M Melia
H B Nunnerley
R Williams
Research01 Sept 1982
British Journal of Cancer

Volume: 46, P: 331-339
BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models

D Li
L Ambrogio
K-K Wong
Research14 Apr 2008
Oncogene

Volume: 27, P: 4702-4711
Fetal Lung Development in Male and Female Nonhuman Primates

Robert H Perelman
Michael J Engle
Philip M Farrell
Research01 Oct 1986
Pediatric Research

Volume: 20, P: 987-991
Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin

Richard A. F. Dixon
Brian K. Kobilka
Catherine D. Strader
Research01 May 1986
Nature

Volume: 321, P: 75-79
Fc receptor phosphorylation during receptor-mediated control of B-cell activation

Walter Hunziker
Terry Koch
Ira Mellman
Research14 Jun 1990
Nature

Volume: 345, P: 628-632
Cataract as a complication of severe microbial keratitis

R Lotti
J K G Dart
Research01 Jul 1992
Eye

Volume: 6, P: 400-403
Therapy-induced APOBEC3A drives evolution of persistent cancer cells

Induction of APOBEC3A in response to targeted therapies drives evolution of drug-tolerant persister cells, suggesting that its suppression may represent a potential therapeutic strategy in the prevention of acquired resistance to lung cancer targeted therapy.

Hideko Isozaki
Ramin Sakhtemani
Aaron N. Hata
Research05 Jul 2023
Nature

Volume: 620, P: 393-401
PI3K/Akt signalling is required for the attachment and spreading, and growth in vivo of metastatic scirrhous gastric carcinoma

T Matsuoka
M Yashiro
J D Roberts
ResearchOpen Access24 Apr 2012
British Journal of Cancer

Volume: 106, P: 1535-1542
HGF-independent potentiation of EGFR action by c-Met

A M Dulak
C T Gubish
J M Siegfried
Research21 Mar 2011
Oncogene

Volume: 30, P: 3625-3635
Cell-free DNA captures tumor heterogeneity and driver alterations in rapid autopsies with pre-treated metastatic cancer

It is currently unclear if cell-free DNA samples from metastatic cancers are as informative as tissue ones for cancer profiling. Here the authors show that cell-free DNA samples from rapid autopsies capture clonal and subclonal alterations of metastatic tumours and reveal more driver alterations than single tissue samples.

Bernard Pereira
Christopher T. Chen
Dejan Juric
ResearchOpen Access27 May 2021
Nature Communications

Volume: 12, P: 1-13
Distinct viral reservoirs in individuals with spontaneous control of HIV-1

In individuals who have achieved natural control of HIV-1 without drug treatment, intact proviral sequences are integrated into genomic regions that are not permissive to active viral transcription, indicating deep latency of the virus.

Chenyang Jiang
Xiaodong Lian
Xu G. Yu
Research26 Aug 2020
Nature

Volume: 585, P: 261-267
Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition

Drug-tolerant but initially EGFR^T790M-negative tumor cells that undergo genetic evolution to acquire resistance to EGFR inhibitors are more resistant than pre-existing EGFR^T790M -positive clones to subsequent therapy.

Aaron N Hata
Matthew J Niederst
Jeffrey A Engelman
Research01 Feb 2016
Nature Medicine

Volume: 22, P: 262-269
A century at the chemistry-biology interface

The field of chemical biology is now hitting its stride. Chemical biologists have developed essential tools that are being used to illuminate complex cellular events. The application of chemical principles to biological phenomena has revealed new opportunities for drug discovery. This report highlights recent progress and exciting new directions in chemical genetics and drug discovery.

Jennifer J Kohler
News & Views01 Jun 2006
Nature Chemical Biology

Volume: 2, P: 288-292
Modeling HIV-1 nuclear entry with nucleoporin-gated DNA-origami channels

By using nuclear pore complex mimics, the authors demonstrate that the cytoplasm-facing Nup358 provides a dock for the HIV-1 capsid, and the nucleoplasm-facing Nup153 positions the capsid for NPC entry. Nup358 and Nup153 thus create an affinity gradient which regulates capsid penetration, whereas Nup62 constitutes a final NPC gatekeeper against HIV-1 capsid entry.

Qi Shen
Qingzhou Feng
Yong Xiong
Research20 Feb 2023
Nature Structural & Molecular Biology

Volume: 30, P: 425-435
Synchrotron radiation facility

K. CODLING
Correspondence12 Jul 1974
Nature

Volume: 250, P: 98
Penicillin

BRIAN J. FORD
Correspondence12 Jul 1974
Nature

Volume: 250, P: 98
The HIV capsid mimics karyopherin engagement of FG-nucleoporins

Dissection of the nuclear pore complex provides a model in which the HIV capsid enters the nucleus through karyopherin mimicry, a mechanism likely to be conserved across other viruses.

C. F. Dickson
S. Hertel
D. A. Jacques
ResearchOpen Access24 Jan 2024
Nature

Volume: 626, P: 836-842
Genetic mechanisms of target antigen loss in CAR19 therapy of acute lymphoblastic leukemia

Mutations in the CD19 gene suggesting irreversible loss of its surface expression are identified in the majority of analyzed cases of CD19^– relapse in two clinical trials of pediatric ALL CD19 CAR T therapy, offering considerations for the rational choice of follow-up therapies.

Elena J. Orlando
Xia Han
Wendy Winckler
Research01 Oct 2018
Nature Medicine

Volume: 24, P: 1504-1506
HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains

Early steps of HIV infection of primary human cells remain poorly understood. Here, Francis et al. show that early viral replication complexes accumulate within nuclear speckles, in reliance on viral capsid/host CPSF6 interactions, and preferentially integrate in speckle-associated genomic domains.

Ashwanth C. Francis
Mariana Marin
Gregory B. Melikyan
ResearchOpen Access14 Jul 2020
Nature Communications

Volume: 11, P: 1-17
Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints

Blocking immune checkpoints is a promising strategy to treat lung cancer, but patients often become resistant to the therapy. Here, the authors analyse resistance in mouse models of lung cancer and show in mice and two patients, an increase in the expression of TIM3, which is also involved in the immune response to cancer.

Shohei Koyama
Esra A. Akbay
Peter S. Hammerman
ResearchOpen Access17 Feb 2016
Nature Communications

Volume: 7, P: 1-9
Cytolytic effects of the complement cleavage product, C3a

J Ferluga
H U Schorlemmer
A C Allison
Research01 Dec 1976
British Journal of Cancer

Volume: 34, P: 626-634
Foreign DNA capture during CRISPR–Cas adaptive immunity

The structure of the Cas1–Cas2 complex bound to a protospacer sequence illustrates how foreign DNA is captured and measured by bacterial proteins in preparation for integration into CRISPR loci.

James K. Nuñez
Lucas B. Harrington
Jennifer A. Doudna
Research21 Oct 2015
Nature

Volume: 527, P: 535-538

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