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Prostatic fibrosis, lower urinary tract symptoms, and BPH

In this Perspectives article, Rodriguez-Nieves and Macoska discuss relationships between prostatic tissue inflammation (from ageing, infection, or other inflammatory disease processes), prostatic tissue fibrosis, lower urinary tract dysfunction (LUTD), and BPH, as well as highlighting recent advances in the use of antifibrotic therapeutic agents for treating LUTD.

Jose A. Rodriguez-Nieves
Jill A. Macoska
Reviews16 Jul 2013
Nature Reviews Urology

Volume: 10, P: 546-550
Identification of Genetic Markers for Prostatic Cancer Progression

Janneke C Alers
Jenneke Rochat
Herman van Dekken
Research01 Jun 2000
Laboratory Investigation

Volume: 80, P: 931-942
Genetic Evaluation of Localized Prostate Cancer in a Cohort of Forty Patients: Gain Of Distal 8q Discriminates Between Progressors and Nonprogressors

Herman van Dekken
Janneke C Alers
Fritz H Schröder
Research01 Jun 2003
Laboratory Investigation

Volume: 83, P: 789-796
Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer

Distinct translocation mechanisms and additional translocation partners for ETS genes are found in prostate cancer. This study also provides the first functional evidence that ETS gene deregulation can promote cancer cell invasion in cell lines and pre-malignant prostate lesions in a transgenic mouse model.

Scott A. Tomlins
Bharathi Laxman
Arul M. Chinnaiyan
Research02 Aug 2007
Nature

Volume: 448, P: 595-599
Evidence for the differential expression of a variant EGF receptor protein in human prostate cancer

E O Olapade-Olaopa
D K Moscatello
F K Habib
ResearchOpen Access10 Dec 1999
British Journal of Cancer

Volume: 82, P: 186-194
Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression

A systematic analysis of metabolites in prostate cancer samples has led to the identification of sarcosine as a putative biomarker detectable in urine, which could potentially be used to aid prostate cancer diagnosis. Sarcosine promotes the invasion of prostate cancer cells and may play a role in metastasis.

Arun Sreekumar
Laila M. Poisson
Arul M. Chinnaiyan
Research01 Feb 2009
Nature

Volume: 457, P: 910-914
Increasing genome instability in adrenocortical carcinoma progression with involvement of chromosomes 3, 9 and X at the adenoma stage

A J Russell
J Sibbald
A M McNicol
ResearchOpen Access24 Sept 1999
British Journal of Cancer

Volume: 81, P: 684-689
A region of interstitial 17q25 allelic loss in ovarian tumors coincides with a defined region of loss in breast tumors

L M Kalikin
T S Frank
E M Petty
Research24 Apr 1997
Oncogene

Volume: 14, P: 1991-1994
Interphase cytogenetics of prostate cancer: fluorescence in situ hybridisation (FISH) analysis of Japanese cases

H Matsuura
T Shiraishi
J Kawamura
Research01 Dec 1996
British Journal of Cancer

Volume: 74, P: 1699-1704
Limiting the location of a putative human prostate cancer tumor suppressor gene at chromosome 13q14.3

Zhengnan Yin
Margaret R Spitz
Jacob Kagan
Research09 Dec 1999
Oncogene

Volume: 18, P: 7576-7583
Limiting the location of putative human prostate cancer tumor suppressor genes on chromosome 18q

Zhengnan Yin
Richard J Babaian
Jacob Kagan
Research26 Apr 2001
Oncogene

Volume: 20, P: 2273-2280
Genetic aberrations in glioblastoma multiforme: translocation of chromosome 10 in an O-2A-like cell line

X Mao
T A Jones
D Sheer
ResearchOpen Access29 Jan 1999
British Journal of Cancer

Volume: 79, P: 724-731
Analysis of the 10q23 chromosomal region and the PTEN gene in human sporadic breast carcinoma

H E Feilotter
V Coulon
M Longy
ResearchOpen Access29 Jan 1999
British Journal of Cancer

Volume: 79, P: 718-723
Identification of potential diagnostic markers of prostate cancer and prostatic intraepithelial neoplasia using cDNA microarray

J H Bull
G Ellison
L Paskins
ResearchOpen Access29 May 2001
British Journal of Cancer

Volume: 84, P: 1512-1519
Phenotypic effects of overexpression of the MMAC1 gene in prostate epithelial cells

R M Sharrard
N J Maitland
ResearchOpen Access19 Sept 2000
British Journal of Cancer

Volume: 83, P: 1102-1109
Complex post-transcriptional regulation of EGF-receptor expression by EGF and TGF-α in human prostate cancer cells

D Seth
K Shaw
P J Leedman
ResearchOpen Access23 Apr 1999
British Journal of Cancer

Volume: 80, P: 657-669
Loss of Nkx3.1 leads to the activation of discrete downstream target genes during prostate tumorigenesis

H Song
B Zhang
J Milbrandt
Research13 Jul 2009
Oncogene

Volume: 28, P: 3307-3319
Reactivation of androgen receptor-regulated lipid biosynthesis drives the progression of castration-resistant prostate cancer

W Han
S Gao
C Cai
ResearchOpen Access23 Oct 2017
Oncogene

Volume: 37, P: 710-721
Detection and expression of human BK virus sequences in neoplastic prostate tissues

Dweepanita Das
Rajal B Shah
Michael J Imperiale
Research19 Jul 2004
Oncogene

Volume: 23, P: 7031-7046

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Prostatic fibrosis, lower urinary tract symptoms, and BPH

Identification of Genetic Markers for Prostatic Cancer Progression

Genetic Evaluation of Localized Prostate Cancer in a Cohort of Forty Patients: Gain Of Distal 8q Discriminates Between Progressors and Nonprogressors

Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer

Evidence for the differential expression of a variant EGF receptor protein in human prostate cancer

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression

Increasing genome instability in adrenocortical carcinoma progression with involvement of chromosomes 3, 9 and X at the adenoma stage

A region of interstitial 17q25 allelic loss in ovarian tumors coincides with a defined region of loss in breast tumors

Interphase cytogenetics of prostate cancer: fluorescence in situ hybridisation (FISH) analysis of Japanese cases

Limiting the location of a putative human prostate cancer tumor suppressor gene at chromosome 13q14.3

Limiting the location of putative human prostate cancer tumor suppressor genes on chromosome 18q

Genetic aberrations in glioblastoma multiforme: translocation of chromosome 10 in an O-2A-like cell line

Analysis of the 10q23 chromosomal region and the PTEN gene in human sporadic breast carcinoma

Identification of potential diagnostic markers of prostate cancer and prostatic intraepithelial neoplasia using cDNA microarray

Phenotypic effects of overexpression of the MMAC1 gene in prostate epithelial cells

Complex post-transcriptional regulation of EGF-receptor expression by EGF and TGF-α in human prostate cancer cells

Loss of Nkx3.1 leads to the activation of discrete downstream target genes during prostate tumorigenesis

Reactivation of androgen receptor-regulated lipid biosynthesis drives the progression of castration-resistant prostate cancer

Detection and expression of human BK virus sequences in neoplastic prostate tissues

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