Nature Search

Single nuclei and spatial profiling of sacrococcygeal teratomas reveals cellular composition and X inactivation heterogeneity

Ernesto J. Rojas
Krinio Giannikou
Diana J. Laird

ResearchOpen Access21 Jan 2026

npj Precision Oncology

P: 1-17

Detection in Invertebrates of Inducible, Reactive Materials Resembling Antibody

JOHN H. PHILLIPS
BENJAMIN J. YARDLEY

Research26 Nov 1960

Nature

Volume: 188, P: 728-730

Complete nucleotide sequence of SV40 DNA

W. Fiers
R. Contreras
M. Ysebaert

Research11 May 1978

Nature

Volume: 273, P: 113-120

Glutamate indicators with increased sensitivity and tailored deactivation rates

iGluSnFR4f and iGluSnFR4s are the latest generation of genetically encoded glutamate sensors. They are advantageous for detecting rapid dynamics and large population activity, respectively, as demonstrated in a variety of applications in the mouse brain.

Abhi Aggarwal
Adrian Negrean
Kaspar Podgorski

ResearchOpen Access23 Dec 2025

Nature Methods

Volume: 23, P: 417-425

Uncertainties of enhanced rock weathering for climate-change mitigation

Enhanced rock weathering (ERW) is a carbon dioxide removal (CDR) strategy that converts atmospheric CO₂ to stable carbonates by applying minerals to agricultural land. This Perspective discusses the potential difficulties in scaling ERW, covering feedstock availability, impacts on soil–plant systems, uncertainties around CDR efficiency along the land–ocean continuum and socio-economic challenges.

Marcus Schiedung
Kirsty J. Harrington
Jordon D. Hemingway

Reviews24 Feb 2026

Nature Reviews Earth & Environment

P: 1-14

Multi-messenger dynamic imaging of laser-driven shocks in water using a plasma wakefield accelerator

The authors demonstrate dual-probe multi-messenger imaging of high-energy-density plasmas based on laser-wakefield-accelerated electrons. This enables spatiotemporally resolved simultaneous probing of plasma hydrodynamics and electromagnetic field evolution with both x-ray and electron beams.

Mario D. Balcazar
Hai-En Tsai
Carolyn C. Kuranz

ResearchOpen Access16 Dec 2025

Nature Communications

Volume: 17, P: 1-14

Synthesis and assembly of hepatitis B virus surface antigen particles in yeast

Pablo Valenzuela
Angelica Medina
Benjamin D. Hall

Research22 Jul 1982

Nature

Volume: 298, P: 347-350

Editorial Expression of Concern: Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer

Yang Li
Lihua Zou
Zhigang Charles Wang

Amendments and Corrections05 Dec 2025

Nature Medicine

Volume: 31, P: 4316

Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function

α/β-hydrolase domain-containing protein 11 (ABHD11) is a mitochondrial hydrolase, and its expression in CD4 + T-cells has been linked to remission status in rheumatoid arthritis. Here the authors report that pharmacological inhibition of ABHD11 modulates T-cell effector function via increased 24,25-epoxycholesterol biosynthesis and subsequent liver X receptor activation.

Benjamin J. Jenkins
Yasmin R. Jenkins
Nicholas Jones

ResearchOpen Access03 Nov 2025

Nature Communications

Volume: 16, P: 1-18

Investigating the neuronal role of the proteasomal ATPase subunit gene PSMC5 in neurodevelopmental proteasomopathies

Variants in the PSMC5 gene impair proteasome function and cellular homeostasis, altering brain development in children. This study reveals underlying molecular mechanisms contributing to this neurodevelopmental phenotype, and suggests therapeutic leads for neurodevelopmental proteasomopathies.

Sébastien Küry
Janelle E. Stanton
Elke Krüger

ResearchOpen Access26 Nov 2025

Nature Communications

Volume: 16, P: 1-21

Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue

ResearchOpen Access08 Jul 2021

Nature

Volume: 600, P: 472-477

Enantioselective protein affinity selection mass spectrometry (E-ASMS)

High-throughput chemical ligand discovery is challenged by false positives. Here, authors introduce a scalable enantioselective affinity-selection mass spectrometry approach for proteome-wide ligand discovery with high sensitivity and selectivity

Xiaoyun Wang
Jianxian Sun
Levon Halabelian

ResearchOpen Access17 Dec 2025

Nature Communications

Volume: 17, P: 1-10

Taurine transporter SLC6A6 expression promotes mesenchymal stromal cell function

Christina M. Kaszuba
Benjamin J. Rodems
Jeevisha Bajaj

ResearchOpen Access08 Jan 2026

Cell Death & Disease

Volume: 17, P: 1-13

Structure of simian virus 40 at 3.8-Å resolution

R. C. Liddington
Y. Yan
S. C. Harrison

Research28 Nov 1991

Nature

Volume: 354, P: 278-284

Transformation of rat cells by an altered polyoma virus genome expressing only the middle-T protein

R. Treisman
U. Novak
R. Kamen

Research13 Aug 1981

Nature

Volume: 292, P: 595-600

Childhood gut microbiome is linked to internalizing symptoms at school age via the functional connectome

Here, the authors find that relative abundances of stress-sensitive gastrointestinal microbes at age 2 years predicts internalizing symptoms in middle childhood through altered emotion-related brain network connectivity.

Francesca R. Querdasi
Jessica P. Uy
Bridget L. Callaghan

ResearchOpen Access30 Oct 2025

Nature Communications

Volume: 16, P: 1-16

Author Correction: Marine phosphorus and atmospheric oxygen were coupled during the Great Oxidation Event

Matthew S. Dodd
Chao Li
Andrey Bekker

Amendments and CorrectionsOpen Access19 Jan 2026

Nature Communications

Volume: 17, P: 1

3′-Terminal nucleotide sequences in the genome RNA of picornaviruses

A.G. PORTER
P. FELLNER
F. BROWN

Research16 Nov 1978

Nature

Volume: 276, P: 298-301

IL-17A is increased in diabetic wounds and impairs keratinocyte function via histone demethylase JMJD3

IL-17A, a cytokine important for tissue repair, can impair healing when increased, contributing to keratinocyte dysfunction in type 2 diabetic wounds. Here, the authors show that IL-17A drives this dysfunction via JMJD3-mediated epigenetic changes, and that blocking this pathway improves wound healing.

Jadie Y. Moon
Sonya J. Wolf
Katherine A. Gallagher

ResearchOpen Access18 Dec 2025

Nature Communications

Volume: 17, P: 1-18

The impact of an oral purified microbiome therapeutic on the gastrointestinal microbiome

An exploratory analysis of the phase 3 ECOSPOR III trial shows that a higher dosage of the oral microbiome therapeutic VOWST led to enhanced pharmacokinetics, increased species engraftment and altered microbiome and metabolite profiles, providing mechanistic insights into how it may prevent Clostridioides difficile infection recurrence.

Jessica A. Bryant
Marin Vulić
Matthew R. Henn

ResearchOpen Access05 Jan 2026

Nature Medicine

Volume: 32, P: 186-196

Stabilizing high-efficiency perovskite solar cells via strategic interfacial contact engineering

Engineering the perovskite–electrical contact interface with sodium heptafluorobutyrate reduces interfacial defects and improves charge transport in perovskite solar cells. Functionalized devices deliver a certified power conversion efficiency of 26.96%, which is fully retained after 1,200 h of continuous operation under 1-sun illumination.

Guixiang Li
Zuhong Zhang
Antonio Abate

ResearchOpen Access07 Nov 2025

Nature Photonics

Volume: 20, P: 55-62

Mapping single-cell diploid chromatin fiber architectures using DAF-seq

Single-molecule chromatin fiber sequencing exposes single-cell-level heterogeneity in the chromatin architecture of individual regulatory elements.

Elliott G. Swanson
Yizi Mao
Andrew B. Stergachis

Research03 Dec 2025

Nature Biotechnology

P: 1-12

Enabling efficient electron injection in stretchable OLED

Insufficient electron injection remains a limiting factor for the performance of stretchable organic light-emitting diodes. Here designs for both electron transport layer and cathode in stretchable organic light-emitting diodes are reported to achieve efficient electron injection.

Wei Liu
Cheng Zhang
Sihong Wang

Research26 Nov 2025

Nature Materials

P: 1-9

The global hydrogen budget

Trends in global H₂ sources and sinks are analysed from 1990 to 2020, and a comprehensive budget for the decade 2010–2020 is presented.

Zutao Ouyang
Robert B. Jackson
Andy Wiltshire

ResearchOpen Access17 Dec 2025

Nature

Volume: 648, P: 616-624

In vivo gene editing of human hematopoietic stem and progenitor cells using envelope-engineered virus-like particles

Virus-like particles are engineered to edit human hematopoietic cells in vivo.

Vladimir V. Botchkarev Jr.
Sean Harrington
Luca Biasco

ResearchOpen Access05 Dec 2025

Nature Biotechnology

P: 1-13

Localized transmission of an aquatic pathogen drives hidden epidemics and population collapse in a terrestrial host

Fine-scale field analysis and modelling of the spatial dynamics of infection of Darwin’s frogs with Batrachochytrium dendrobatidis fungus identifies highly localized transmission dynamics that generate clustered epidemics and can drive collapse of local subpopulations.

Andrés Valenzuela-Sánchez
Soledad Delgado-Oyarzún
Leonardo D. Bacigalupe

ResearchOpen Access02 Jan 2026

Nature Ecology & Evolution

Volume: 10, P: 308-317

Human genetics implicate thromboembolism in the pathogenesis of long COVID in individuals of European ancestry

Schuermans et al. discovered that genetic predisposition to thromboembolism is associated with a greater risk of post-acute sequelae after SARS-CoV-2 infection, including long COVID, and downstream analyses implicated PAR-1 as a potential contributor to long COVID.

Art Schuermans
Andreas Verstraete
Peter Verhamme

Research16 Dec 2025

Nature Cardiovascular Research

Volume: 4, P: 1662-1676

Author Correction: Stabilizing high-efficiency perovskite solar cells via strategic interfacial contact engineering

Guixiang Li
Zuhong Zhang
Antonio Abate

Amendments and CorrectionsOpen Access22 Jan 2026

Nature Photonics

Volume: 20, P: 241

Multitrait analyses identify genetic variants associated with aortic valve function and aortic stenosis risk

Genome-wide association studies (GWAS) of deep learning-derived measurements of aortic valve function, along with multitrait analyses incorporating disease-based GWAS, identify 166 genetic loci associated with aortic valve function or aortic stenosis.

Shinwan Kany
Joel T. Rämö
James P. Pirruccello

ResearchOpen Access19 Dec 2025

Nature Genetics

Volume: 58, P: 47-56

Calendar of Centenaries, 1962

J. M. EYLES

Research06 Jan 1962

Nature

Volume: 193, P: 7

LncRNA CISTR-ACT regulates cell size in human and mouse by guiding FOSL2

Establishment and maintenance of appropriate cell size is a prerequisite for cells to function efficiently. Here, Kiriakopulos et al. reveal that the lncRNA CISTR-ACT maintains cell size across cell types in humans and mice by regulating cell morphogenesis genes in trans via guidance of the transcription factor FOSL2.

Katerina Kiriakopulos
Katty Soleimanpour
Philipp G. Maass

ResearchOpen Access16 Dec 2025

Nature Communications

Volume: 17, P: 1-19

Dietary restriction reprograms CD8⁺ T cell fate to enhance anti-tumour immunity and immunotherapy responses

Dietary restriction promotes the expansion of effector T cells via ketone bodies, which enhances anti-tumour immunity and synergizes with immunotherapy in mice.

Brandon M. Oswald
Lisa M. DeCamp
Russell G. Jones

ResearchOpen Access09 Dec 2025

Nature Metabolism

Volume: 7, P: 2489-2509

Inferring structural variant cancer cell fraction

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

Marek Cmero
Ke Yuan
Christian von Mering

ResearchOpen Access05 Feb 2020

Nature Communications

Volume: 11, P: 1-15

Control of Gene Transcription in T-even Bacteriophages: Alterations in RNA Polymerase accompanying Phage Infection

ROBERT J. CROUCH
BENJAMIN D. HALL
GORDON HAGER

Research02 Aug 1969

Nature

Volume: 223, P: 476-479

Distribution of Metals and Catecholamines in Bovine Adrenal Medulla Sub-Cellular Fractions

J. L. BOROWITZ
K. FUWA
N. WEINER

Research01 Jan 1965

Nature

Volume: 205, P: 42-43

An Improved Method for the Characterization of Human Haemoglobin Mutants: Identification of α₂β₂^95GLU, Haemoglobin N (Baltimore)

J. B. CLEGG
M. A. NAUGHTON
D. J. WEATHERALL

Research28 Aug 1965

Nature

Volume: 207, P: 945-947

12,13-diHOME protects against the age-related decline in cardiovascular function via attenuation of CaMKII

Cardiovascular function declines with age. In this study, the authors show that the BAT-derived lipokine 12,13-diHOME preserves cardiac function in aged mice by attenuating pathological CaMKII activity.

Shinsuke Nirengi
Benjamin Buck
Kristin I. Stanford

ResearchOpen Access02 Aug 2025

Nature Communications

Volume: 16, P: 1-15

Operating two exchange-only qubits in parallel

Parallel operation of two exchange-only qubits consisting of six quantum dots arranged linearly is shown to be achievable and maintains qubit control quality compared with sequential operation, with potential for use in scaled quantum computing.

Mateusz T. Mądzik
Florian Luthi
James S. Clarke

ResearchOpen Access26 Nov 2025

Nature

Volume: 647, P: 870-875

Analyses of non-coding somatic drivers in 2,658 cancer whole genomes

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

Esther Rheinbay
Morten Muhlig Nielsen
Christian von Mering

ResearchOpen Access05 Feb 2020

Nature

Volume: 578, P: 102-111

RNA structure modulates Cas13 activity and enables mismatch detection

An effective CRISPR RNA occlusion strategy enhances mismatch detection when using Cas13.

Benjamin B. Larsen
Ofer Kimchi
Cameron Myhrvold

ResearchOpen Access23 Oct 2025

Nature Biotechnology

P: 1-9

Biomimetic supramolecular protein matrix restores structure and properties of human dental enamel

Regrowth of lost enamel in tooth decay and sensitivity is a major obstacle to overcome. Here, the authors report on a protein-based material that mimics features of natural enamel formation, allowing for epitaxial growth of apatite nanocrystals to restore enamel structure and function.

Abshar Hasan
Andrey Chuvilin
Alvaro Mata

ResearchOpen Access04 Nov 2025

Nature Communications

Volume: 16, P: 1-18

Complex genetic effects linked to plasma protein abundance in the UK Biobank

The authors present a deep learning approach to uncover complex genetic effects on circulating protein levels. They reveal new interactions and dominance patterns using UK Biobank proteomics data.

Arnor I. Sigurdsson
Justus F. Gräf
Simon Rasmussen

ResearchOpen Access14 Dec 2025

Nature Communications

Volume: 17, P: 1-15

Liraglutide in mild to moderate Alzheimer’s disease: a phase 2b clinical trial

Results from the phase ELAD 2 trial reveal that liraglutide is safe and well tolerated in people with mild to moderate Alzheimer’s disease but does not significantly slow brain metabolism decline.

Paul Edison
Grazia Daniela Femminella
Clive Ballard

ResearchOpen Access01 Dec 2025

Nature Medicine

Volume: 32, P: 353-361

Nucleotide sequence of the origin of replication in bacteriophage ΦX174 RF DNA

S. A. Langeveld
A. D. M. van Mansfeld
P. J. Weisbeek

Research02 Feb 1978

Nature

Volume: 271, P: 417-420

Intracellular interactions shape antiviral resistance outcomes in poliovirus via eco-evolutionary feedback

A model of intrahost poliovirus replication shows that, after several rounds of replication, pocapavir, a poliovirus capsid inhibitor, collapses viral density, preventing intracellular interactions that allow drug-susceptible viruses to sensitize resistant ones. These results suggest that a low dosage of pocapavir may be beneficial in poliovirus treatment.

Alexander J. Robertson
Benjamin Kerr
Alison F. Feder

Research05 Dec 2025

Nature Ecology & Evolution

P: 1-10

Dejerine–Sottas syndrome associated with point mutation in the peripheral myelin protein 22 (PMP22) gene

Benjamin B. Roa
Peter J. Dyck
James R. Lupski

Research01 Nov 1993

Nature Genetics

Volume: 5, P: 269-273

Centenary of The Engineer

W. J. PRIEST

Research07 Jan 1956

Nature

Volume: 177, P: 10-11

Genetic architecture and mechanisms of host-microbiome interactions from a multi-cohort analysis of outbred laboratory rats

The intestinal microbiome is shaped by genetics and environment. Here, the authors show in rats that host genetic effects, including indirect social effects, influence microbiome composition, identify replicated loci, and reveal mechanisms contributing to microbiome heritability.

Hélène Tonnelé
Denghui Chen
Amelie Baud

ResearchOpen Access18 Dec 2025

Nature Communications

Volume: 16, P: 1-17

Universal consensus 3D segmentation of cells from 2D segmented stacks

u-Segment3D is a universal framework that translates and enhances 2D instance segmentations to a 3D consensus instance segmentation without training data. It performs well across diverse datasets, including cells with complex morphologies.

Felix Y. Zhou
Zach Marin
Gaudenz Danuser

ResearchOpen Access11 Nov 2025

Nature Methods

Volume: 22, P: 2386-2399

Lifting regenerative barriers promotes epithelial cell fate plasticity supporting lineage conversion

This study established the HIF1a–SOX9 axis as a key regulatory barrier that limits epithelial cell fate plasticity, safeguarding against premature responses to incomplete or inadequate instructive cues during tissue repair.

Maria T. Bejar
Paula Jimenez-Gomez
Maria P. Alcolea

ResearchOpen Access27 Nov 2025

Nature Communications

Volume: 16, P: 1-24

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