Conventional antibiotics, which target the infectious agent, are subject to the development of antibiotic resistance. An alternative approach is to focus on host factors that support pathogen growth. A kinase inhibitor screen identified AKT1 as a central molecule essential for intracellular survival of Salmonella typhimurium and Mycobacterium tuberculosis and thus presenting a putative drug target.
- Coenraad Kuijl
- Nigel D. L. Savage
- Jacques Neefjes
