Nature Search

DNA methylation and transcriptional trajectories during human development and reprogramming of isogenic pluripotent stem cells

While DNA methylation and gene expression data are widely available for animal models, comprehensive data from human development is rarer. Here, the authors generated transcriptional and DNA methylation data from 21 organs during human development and 6 isogenic induced pluripotent stem cell lines.

Matthias S. Roost
Roderick C. Slieker
Susana M. Chuva de Sousa Lopes
ResearchOpen Access13 Oct 2017
Nature Communications

Volume: 8, P: 1-11
The global biogeography of tree leaf form and habit

Integrating inventory data with machine learning models reveals the global composition of tree types—needle-leaved evergreen individuals dominate, followed by broadleaved evergreen and deciduous trees—and climate change risks.

Haozhi Ma
Thomas W. Crowther
Constantin M. Zohner
ResearchOpen Access23 Oct 2023
Nature Plants

Volume: 9, P: 1795-1809
Telomere dysfunction induces metabolic and mitochondrial compromise

Here it is shown that telomere dysfunction drives metabolic and mitochondrial compromise. Mice with dysfunctional telomeres activate p53, which in turn represses PGC-1α and PGC-1β, master regulators of metabolic and mitochondrial processes. This results in reduced mitochondrial mass, mitochondrial dysfunction and reduced ATP generation, impaired gluconeogenesis, cariomyopathy and increased reactive oxygen species. This telomere–p53–PGC pathway shows how telomere dysfunction may compromise organ function and contribute to age-related disorders.

Ergün Sahin
Simona Colla
Ronald A. DePinho
Research09 Feb 2011
Nature

Volume: 470, P: 359-365
Mutations in VPS33B, encoding a regulator of SNARE-dependent membrane fusion, cause arthrogryposis–renal dysfunction–cholestasis (ARC) syndrome

Paul Gissen
Colin A Johnson
Eamonn R Maher
Research28 Mar 2004
Nature Genetics

Volume: 36, P: 400-404
Serrate2 is disrupted in the mouse limb-development mutant syndactylism

Arend Sidow
Monique S. Bulotsky
Eric S. Lander
Research16 Oct 1997
Nature

Volume: 389, P: 722-725
The ubiquitin-specific protease USP28 is required for MYC stability

Nikita Popov
Michael Wanzel
Martin Eilers
Research10 Jun 2007
Nature Cell Biology

Volume: 9, P: 765-774
Differential post-translational modification of the tumour suppressor proteins Rb and p53 modulate the rates of radiation-induced apoptosis in vivo

M Wallace
P J Coates
K L Ball
Research05 Jul 2001
Oncogene

Volume: 20, P: 3597-3608
Multiple common variants for celiac disease influencing immune gene expression

David van Heel and colleagues report results of a large genome-wide association study of celiac disease. Most of the associated loci contain genes with immune functions, and over half harbor risk variants that are correlated with variation in cis gene expression.

Patrick C A Dubois
Gosia Trynka
David A van Heel
Research28 Feb 2010
Nature Genetics

Volume: 42, P: 295-302
The Theory of Screws; a Study in the Dynamics of a Rigid Body

J. D. E.
Books & Arts13 Apr 1876
Nature

Volume: 13, P: 463-464
A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine

Amplification of PDGFRα is a common alteration in glioblastoma. In this study, the authors develop a genetically engineered mouse model of GBM based on autocrine, chronic stimulation of overexpressed PDGFR and discover Stathmin1 as an important PDGFRα regulated-protein involved in the response to vinstabline.

Hyun Jung Jun
Vicky A. Appleman
Al Charest
ResearchOpen Access06 Aug 2018
Nature Communications

Volume: 9, P: 1-13
Dr. F. L. Kitchin, F.R.S

J. S. F.
Comments & Opinion10 Mar 1934
Nature

Volume: 133, P: 350-351
A Periodic Mercury Pump

FREDERICK J. SMITH
News03 Aug 1893
Nature

Volume: 48, P: 320-321
Some New Material on Robert Dick, Baker of Thurso, Geologist and Botanist

J. SAXON
J. I. BRAMMAN
N. CAMPBELL
News01 Apr 1966
Nature

Volume: 210, P: 253
The genome of woodland strawberry (Fragaria vesca)

The International Strawberry Sequencing Consortium reports the draft genome of the woodland strawberry (Fragaria vesca). The genome of this diploid species should serve as a reference genome for the Fragaria genus, as the cultivated strawberry (Fragaria × ananassa) is an octoploid where F. vesca is predicted to be a subgenome donor.

Vladimir Shulaev
Daniel J Sargent
Kevin M Folta
ResearchOpen Access26 Dec 2010
Nature Genetics

Volume: 43, P: 109-116
An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection

Deborah Palliser
Dipanjan Chowdhury
Judy Lieberman
Research23 Nov 2005
Nature

Volume: 439, P: 89-94
G1 cyclins link proliferation, pluripotency and differentiation of embryonic stem cells

Liu et al. show that G1 cyclins and their cyclin-dependent kinases regulate the pluripotent state by driving phosphorylation of Nanog, Oct4 and Sox2, thereby identifying a direct connection between G1 cyclins and pluripotency factors.

Lijun Liu
Wojciech Michowski
Piotr Sicinski
Research13 Feb 2017
Nature Cell Biology

Volume: 19, P: 177-188
DNA methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional control

Bernhard Radlwimmer and colleagues report whole-genome bisulfite sequencing of 13 Burkitt lymphomas and nine follicular lymphomas. They find that both types of germinal center B cell lymphomas show global hypomethylation compared to normal germinal center B cell precursors and identify regions of differential methylation that correlate with somatic mutations and differential gene expression.

Helene Kretzmer
Stephan H Bernhart
Bernhard Radlwimmer
Research05 Oct 2015
Nature Genetics

Volume: 47, P: 1316-1325
A one-hit model of cell death in inherited neuronal degenerations

Geoff Clarke
Richard A. Collins
Roderick R. McInnes
Research13 Jul 2000
Nature

Volume: 406, P: 195-199
Enzyme polymorphism in feral, outbred and inbred rats (Rattus norvegicus)

K Eriksson
O Halkka
A Saura
Research01 Dec 1976
Heredity

Volume: 37, P: 341-349
Prostaglandins

R. J. Flower
Books & Arts18 Nov 1976
Nature

Volume: 264, P: 301
Molecular velcro in Flatland

A layer of disordered proteins can selectively control the diffusion of particles along a surface.

Jurriaan Huskens
News & Views03 Jul 2014
Nature Nanotechnology

Volume: 9, P: 500-502
Die Arten der Gattung Ephedra

J. G. B.
Books & Arts27 Feb 1890
Nature

Volume: 41, P: 390
NMDA receptors regulate developmental gap junction uncoupling via CREB signaling

Harsha Arumugam
Xinhuai Liu
Andrei B Belousov
Research20 Nov 2005
Nature Neuroscience

Volume: 8, P: 1720-1726
Transcriptional reprogramming of skeletal muscle stem cells by the niche environment

Aging leads to significant alteration in the gene expression of muscle stem cells. In vivo exposure of muscle stem cells from aged mice to a young niche environment restores the expression of a significant portion of age-altered genes in mice.

Felicia Lazure
Rick Farouni
Vahab D. Soleimani
ResearchOpen Access01 Feb 2023
Nature Communications

Volume: 14, P: 1-16
Intracellular sodium elevation reprograms cardiac metabolism

The failing heart is characterised by both alterations in mitochondrial metabolism and an elevation of cytosolic sodium. Here, the authors use ²³Na NMR and metabolic profiling to show these are related, and that elevation in intracellular Na reprograms cardiac substrate utilisation via effects on mitochondrial Na/Ca exchange.

Dunja Aksentijević
Anja Karlstaedt
Michael J. Shattock
ResearchOpen Access28 Aug 2020
Nature Communications

Volume: 11, P: 1-14
Mutation of the gene encoding human TTF-2 associated with thyroid agenesis, cleft palate and choanal atresia

Roderick J. Clifton-Bligh
John M. Wentworth
V. Krishna Chatterjee
Research01 Aug 1998
Nature Genetics

Volume: 19, P: 399-401
Responding to eruptive transitions during the 2020–2021 eruption of La Soufrière volcano, St. Vincent

The 2020 – 2021 eruption of La Soufrière volcano transitioned from an effusive to explosive eruption style. Here the authors show that input from multiple monitoring datasets and an evolving conceptual model were key to anticipating and responding to the eruptive transition at the La Soufrière volcano, St. Vincent, in a resource-constrained setting.

E. P. Joseph
M. Camejo-Harry
R. S. J. Sparks
ResearchOpen Access15 Jul 2022
Nature Communications

Volume: 13, P: 1-15
Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

Sofia Papadia
Francesc X Soriano
Giles E Hardingham
Research23 Mar 2008
Nature Neuroscience

Volume: 11, P: 476-487
Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres

Telomere shortening, senescence and aging are connected, but how the signal at shortening telomeres is transmitted to the cell more globally is unclear. H3 and H4 synthesis is now shown to be reduced as cell cultures age. This alters expression of Asf1, a histone chaperone, compromising the ability of aging cells to restore chromatin after replication and DNA. In this way localized effects at shortening telomeres can be propagated throughout the cell.

Roderick J O'Sullivan
Stefan Kubicek
Jan Karlseder
Research03 Oct 2010
Nature Structural & Molecular Biology

Volume: 17, P: 1218-1225
Our Salad Herbs

C. J. ROBINSON
News18 Aug 1870
Nature

Volume: 2, P: 317
Author Correction: The power of genetic diversity in genome-wide association studies of lipids

Sarah E. Graham
Shoa L. Clarke
Cristen J. Willer
Amendments and Corrections26 May 2023
Nature

Volume: 618, P: E19-E20
Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia

MLL fusion genes often encode leukemogenic proteins that depend on interaction with menin, a component of the MLL SET1-like histone methyltransferase complex. MI-2 and MI-3 are the first small molecules that can block menin–MLL fusion protein interaction and their oncogenic effects in cells.

Jolanta Grembecka
Shihan He
Tomasz Cierpicki
Research29 Jan 2012
Nature Chemical Biology

Volume: 8, P: 277-284
Author Correction: International consensus statement on the diagnosis and management of phaeochromocytoma and paraganglioma in children and adolescents

Ruth T. Casey
Emile Hendriks
Christina Pamporaki
Amendments and Corrections27 Aug 2024
Nature Reviews Endocrinology

Volume: 20, P: 760
GroE structures galore

The stuctures of the co-chaperonin GroES and of the GroEL•ATPγS complex raise a host of tantalizing questions and whet the appetite for even more challenging structures, the various GroEL•nucleotide•GroES complexes which facilitate folding.

George H. Lorimer
Matthew J. Todd
News & Views01 Feb 1996
Nature Structural Biology

Volume: 3, P: 116-121
Molecular exploration of fossil eggshell uncovers hidden lineage of giant extinct bird

The evolution and systematics of Madagascar’s extinct elephant birds remains unclear. Here, the authors recover genetic, stable isotope, morphological, and geographic data from fossil eggshell to describe variation among clades, identifying cryptic diversity and potential drivers of speciation.

Alicia Grealy
Gifford H. Miller
Michael Bunce
ResearchOpen Access28 Feb 2023
Nature Communications

Volume: 14, P: 1-14
Ca²⁺ signalling checkpoints in cancer: remodelling Ca²⁺ for cancer cell proliferation and survival

Changes in the levels of the second messenger Ca²⁺ can result in the activation of broadly proliferative or cytotoxic responses. As reviewed here, to tip the balance in their favour, cancer cells often remodel the expression or activity of their Ca²⁺signalling apparatus.

H. Llewelyn Roderick
Simon J. Cook
Reviews01 May 2008
Nature Reviews Cancer

Volume: 8, P: 361-375
The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models

The Microarray Quality Control consortium pitted 36 teams against each other to evaluate methods for creating genomic classifiers, computational tools for interpreting gene expression profiles. The performance of the classifiers on blinded validation data—and metadata on the analytic methods—reveal the challenges facing the field.

Leming Shi
Gregory Campbell
Russell D Wolfinger
Research30 Jul 2010
Nature Biotechnology

Volume: 28, P: 827-838
A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium

The Sequencing Quality Control (SEQC) consortium shows that junction discovery and differential gene expression profiling with RNA-seq can be robust but transcript-level and absolute measurements remain challenging.

Zhenqiang Su
Paweł P Łabaj
Leming Shi
Research24 Aug 2014
Nature Biotechnology

Volume: 32, P: 903-914
FIC1 Is Expressed at Apical Membranes of Different Epithelial Cells in the Digestive Tract and Is Induced in the Small Intestine During Postnatal Development of Mice

Saskia W C van Mil
Masja M van Oort
Leo W J Klomp
Research01 Dec 2004
Pediatric Research

Volume: 56, P: 981-987
A sequence-oriented comparison of gene expression measurements across different hybridization-based technologies

Winston Patrick Kuo
Fang Liu
Tor-Kristian Jenssen
Research02 Jul 2006
Nature Biotechnology

Volume: 24, P: 832-840
Anthropogenic climate change has driven over 5 million km² of drylands towards desertification

Drylands cover nearly half of Earth’s surface, yet how they will fare in light of anthropogenic climate change is debated. Here the authors find that over the past 40 years climate change has pushed ~13% of drylands towards desertification threatening hundreds of millions of people in developing nations.

A. L. Burrell
J. P. Evans
M. G. De Kauwe
ResearchOpen Access31 Jul 2020
Nature Communications

Volume: 11, P: 1-11
Functional composition of the Amazonian tree flora and forests

Using 13 functional traits we characterize the Amazonian trees and the communities they form. Amazonian tree communities are distributed along a fast-slow-spectrum. This results in clear differences in traits among these forests, as well as their biomass and biomass productivity.

Hans ter Steege
Lourens Poorter
Georgia Pickavance
ResearchOpen Access03 Mar 2025
Communications Biology

Volume: 8, P: 1-17
Eighteen eighty nine and all that

An anniversarial cornucopia featuring rubber gloves, Louis Ilosvay de Nagy-Ilosva, the Eiffel Tower, nuclear fission, the Swedish Academy of Sciences, J. Willard Gibbs, the omega minus meson, Antoine Laurent Lavoisier, Timothy the tortoise and much, much more.

W. F. Bynum
J. L. Heilbron
Comments & Opinion05 Jan 1989
Nature

Volume: 337, P: 29-32
Response of rat lung to inhaled tobacco smoke with or without prior exposure to 3,4-benzpyrene (BP) given by intratracheal instillation

B R Davis
J K Whitehead
F J Roe
Research01 Apr 1975
British Journal of Cancer

Volume: 31, P: 469-484
Massive parallelism, randomness and genomic advances

J. Craig Venter
Samuel Levy
Aaron Halpern
Reviews01 Mar 2003
Nature Genetics

Volume: 33, P: 219-227
An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia

Michelle Kelliher, Bradley Bernstein and colleagues identify T cell acute lymphoblastic leukemia cells that are resistant to γ-secretase inhibitor treatment and characterize the epigenetic mechanism of resistance.

Birgit Knoechel
Justine E Roderick
Bradley E Bernstein
Research02 Mar 2014
Nature Genetics

Volume: 46, P: 364-370
The Marine Fauna in Lake Tanganyika, and the Advisability of Further Exploration in the Great African Lakes

J. E. S. MOORE
News25 Aug 1898
Nature

Volume: 58, P: 404-408
An Immunocytochemical and In Situ Hybridization Analysis of Annexin 1 Expression in Rat Mast Cells: Modulation by Inflammation and Dexamethasone

Sonia M Oliani
Helen C Christian
Mauro Perretti
Research01 Sept 2000
Laboratory Investigation

Volume: 80, P: 1429-1438
She1 affects dynein through direct interactions with the microtubule and the dynein microtubule-binding domain

Dynein is a microtubule motor the motility of which is affected by the microtubule-associated protein She1. Here, the authors show that She1 alters dynein stepping behavior and increases its microtubule affinity through simultaneous interactions with the microtubule and dynein microtubule binding domain.

Kari H. Ecklund
Tatsuya Morisaki
Steven M. Markus
ResearchOpen Access15 Dec 2017
Nature Communications

Volume: 8, P: 1-16
Author Correction: Single-nuclei and bulk-tissue gene-expression analysis of pheochromocytoma and paraganglioma links disease subtypes with tumor microenvironment

Magnus Zethoven
Luciano Martelotto
Richard W. Tothill
Amendments and CorrectionsOpen Access09 Jan 2023
Nature Communications

Volume: 14, P: 1

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