Isolated limb perfusion (ILP) combined with melphalan and TNF-α produces striking response rates for the treatment of bulky melanoma metastases, soft tissue sarcomas and various other tumors. TNF-α-based ILP is a well-established treatment that helps to avoid amputations, and this represents an important approach that is now widely practiced in Europe.
- Dirk J Grünhagen
- Johannes HW de Wilt
- Alexander MM Eggermont
