Nature Search

A human-specific regulatory mechanism revealed in a pre-implantation model

Genetic manipulation of blastoids reveals the role of recently emerged transposable elements and genes in human development.

Raquel Fueyo
Sicong Wang
Joanna Wysocka
ResearchOpen Access01 Oct 2025
Nature

P: 1-10
A mutant oncolytic adenovirus targeting the Rb pathway produces anti-glioma effect in vivo

Juan Fueyo
Candelaria Gomez-Manzano
Athanassios P Kyritsis
Research20 Jan 2000
Oncogene

Volume: 19, P: 2-12
Overexpression of E2F‐1 in glioma triggers apoptosis and suppresses tumor growth in vitro and in vivo

J. Fueyo
C. Gomez-Manzano
A. P. Kyritsis
Research01 Jun 1998
Nature Medicine

Volume: 4, P: 685-690
The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models

The oncolytic virus Delta-24-RGD is in clinical trial for adult glioma. Here, the authors show that this virus elicits an immune response in mouse models of pediatric high-grade glioma and diffuse pontine intrinsic glioma, resulting in improved survival.

Naiara Martínez-Vélez
Marc Garcia-Moure
Marta M. Alonso
ResearchOpen Access28 May 2019
Nature Communications

Volume: 10, P: 1-10
Concordant methylation of the ER and N33 genes in glioblastoma multiforme

Qing Li
Ann Jedlicka
Jean-Pierre J Issa
Research17 Jun 1998
Oncogene

Volume: 16, P: 3197-3202
Inhibition of breast cancer growth in vivo by antiangiogenesis gene therapy with adenovirus-mediated antisense-VEGF

S-A Im
J-S Kim
W K A Yung
ResearchOpen Access01 May 2001
British Journal of Cancer

Volume: 84, P: 1252-1257
The risk and prognosis of cancer after hospitalisation for herpes zoster: a population-based follow-up study

H T Sørensen
J H Olsen
L Mellemkjær
ResearchOpen Access24 Aug 2004
British Journal of Cancer

Volume: 91, P: 1275-1279
JMJD3 intrinsically disordered region links the 3D-genome structure to TGFβ-dependent transcription activation

Here the authors demonstrate that TGFβ drives multi-enhancer contacts and ultimately gene activation during neuronal commitment, and that this requires the intrinsically disordered region (IDR) of the histone demethylase JMJD3 likely through its role in promoting phase-separated biomolecular condensates.

Marta Vicioso-Mantis
Raquel Fueyo
Marian A. Martínez-Balbás
ResearchOpen Access07 Jun 2022
Nature Communications

Volume: 13, P: 1-15
Gain and loss of function variants in EZH1 disrupt neurogenesis and cause dominant and recessive neurodevelopmental disorders

An apparent redundant role with EZH2 has rendered EZH1 as a secondary player in PRC2-mediated homeostasis regulation. Here, the authors report that gain- and loss-of-function variants in EZH1 cause neurodevelopmental disorders, highlighting its functional relevance.

Carolina Gracia-Diaz
Yijing Zhou
Naiara Akizu
ResearchOpen Access11 Jul 2023
Nature Communications

Volume: 14, P: 1-18
Inhibiting tumorigenic potential by restoration of p16 in nasopharyngeal carcinoma

G L Wang
K W Lo
D P Huang
ResearchOpen Access12 Nov 1999
British Journal of Cancer

Volume: 81, P: 1122-1126
Decoding the hallmarks of allograft dysfunction with a comprehensive pan-organ transcriptomic atlas

A comprehensive analysis of omics data from biopsies and blood samples from more than 12,000 cases of heart, lung, liver and kidney transplants provides insights into shared mechanisms of allograft dysfunction across organs.

Harry Robertson
Hani Jieun Kim
Ellis Patrick
ResearchOpen Access18 Jun 2024
Nature Medicine

Volume: 30, P: 3748-3757
Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance

Catherine A Sabatos
Sumone Chakravarti
Vijay K Kuchroo
Research12 Oct 2003
Nature Immunology

Volume: 4, P: 1102-1110
The risk of a subsequent cancer diagnosis after herpes zoster infection: primary care database study

S J Cotton
J Belcher
R D Neal
ResearchOpen Access29 Jan 2013
British Journal of Cancer

Volume: 108, P: 721-726
Oncolytic adenoviral mutants induce a novel mode of programmed cell death in ovarian cancer

S K Baird
J L Aerts
I A McNeish
Research10 Dec 2007
Oncogene

Volume: 27, P: 3081-3090
Tim-3 inhibits T helper type 1–mediated auto- and alloimmune responses and promotes immunological tolerance

Alberto Sánchez-Fueyo
Jane Tian
Terry B Strom
Research12 Oct 2003
Nature Immunology

Volume: 4, P: 1093-1101
Reduction of nontarget infection and systemic toxicity by targeted delivery of conditionally replicating viruses transported in mesenchymal stem cells

J L Dembinski
E L Spaeth
F C Marini
Research30 Oct 2009
Cancer Gene Therapy

Volume: 17, P: 289-297
Expression of pepsinogen C in human breast tumours and correlation with clinicopathologic parameters

I Diez-Itza
AM Merino
C López-Otín
Research01 Sept 1993
British Journal of Cancer

Volume: 68, P: 637-640
53BP1 cooperation with the REV7–shieldin complex underpins DNA structure-specific NHEJ

The specificity of 53BP1 and its co-factors for particular DNA substrates during non-homologous end joining (NHEJ) derives from REV7–shieldin, a four-subunit DNA-binding complex that is required for REV7-dependent NHEJ but not for REV7-dependent DNA interstrand cross-link repair.

Hind Ghezraoui
Catarina Oliveira
J. Ross Chapman
Research25 Jul 2018
Nature

Volume: 560, P: 122-127
Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation

Ignacio Varela
Juan Cadiñanos
Carlos López-Otín
Research03 Aug 2005
Nature

Volume: 437, P: 564-568
The fate of pancreatic tumor cell lines following p16 overexpression depends on the modulation of CDK2 activity

J Calbó
C Serna
A Mazo
Research13 Aug 2004
Cell Death & Differentiation

Volume: 11, P: 1055-1065
Myc lacks E2F1's ability to suppress skin carcinogenesis

Robert J Rounbehler
Robin Schneider-Broussard
David G Johnson
Research06 Sept 2001
Oncogene

Volume: 20, P: 5341-5349
Persistent DNA damage induced by ultraviolet light inhibits p21^waf1 and bax expression: implications for DNA repair, UV sensitivity and the induction of apoptosis

Bruce C McKay
Mats Ljungman
Andrew J Rainbow
Research10 Aug 1998
Oncogene

Volume: 17, P: 545-555
Collagenolytic and gelatinolytic matrix metalloproteinases and their inhibitors in basal cell carcinoma of skin: comparison with normal skin

J Varani
Y Hattori
T M Johnson
ResearchOpen Access07 Jan 2000
British Journal of Cancer

Volume: 82, P: 657-665
T cells and autoimmune kidney disease

T cells are critical drivers of autoimmunity and related organ damage, by supporting B-cell differentiation and antibody production or by directly promoting inflammation and cytotoxicity. This Review discusses the immune features of autoimmune nephropathies, with a focus on systemic lupus erythematosus and the role of T cells.

Abel Suárez-Fueyo
Sean J. Bradley
George C. Tsokos
Reviews13 Mar 2017
Nature Reviews Nephrology

Volume: 13, P: 329-343
Expression of collagenases-1 and -3 and their inhibitors TIMP-1 and -3 correlates with the level of invasion in malignant melanomas

K Airola
T Karonen
U K Saarialho-Kere
ResearchOpen Access23 Apr 1999
British Journal of Cancer

Volume: 80, P: 733-743
Altered expression of the suppressors PML and p53 in glioblastoma cells with the antisense-EGF-receptor

X X Tian
J Y H Chan
H K Ng
ResearchOpen Access29 Oct 1999
British Journal of Cancer

Volume: 81, P: 994-1001
Induction of melanoma-associated antigen systemic immunity upon intratumoral delivery of interferon-γ retroviral vector in melanoma patients

Shigeyuki Fujii
Sharon Huang
Dave S B Hoon
Research28 Sept 2000
Cancer Gene Therapy

Volume: 7, P: 1220-1230
Epithelial dysfunction is prevented by IL-22 treatment in a Citrobacter rodentium-induced colitis model that shares similarities with inflammatory bowel disease

Qifan Zhu
Daniel Korenfeld
Radhika Goenka
Research13 Nov 2022
Mucosal Immunology

Volume: 15, P: 1338-1349
Angiopoietin-2 decreases vascular endothelial growth factor expression by modulating HIF-1α levels in gliomas

O-H Lee
J Xu
C Gomez-Manzano
Research20 Aug 2007
Oncogene

Volume: 27, P: 1310-1314
Tie2-mediated multidrug resistance in malignant gliomas is associated with upregulation of ABC transporters

V Martin
J Xu
C Gomez-Manzano
Research04 May 2009
Oncogene

Volume: 28, P: 2358-2363
Combination effect of oncolytic adenovirotherapy and TRAIL gene therapy in syngeneic murine breast cancer models

W Guo
H Zhu
B Fang
Research22 Jul 2005
Cancer Gene Therapy

Volume: 13, P: 82-90
C-Jun N-terminal kinases are required for oncolytic adenovirus-mediated autophagy

S R Klein
S Piya
J Fueyo
Research26 Jan 2015
Oncogene

Volume: 34, P: 5295-5301
Melatonin-induced methylation of the ABCG2/BCRP promoter as a novel mechanism to overcome multidrug resistance in brain tumour stem cells

V Martín
A M Sanchez-Sanchez
C Rodriguez
ResearchOpen Access30 Apr 2013
British Journal of Cancer

Volume: 108, P: 2005-2012
Combination of the oncolytic adenovirus ICOVIR-5 with chemotherapy provides enhanced anti-glioma effect in vivo

M M Alonso
C Gomez-Manzano
J Fueyo
Research08 Jun 2007
Cancer Gene Therapy

Volume: 14, P: 756-761
Correction: Corrigendum

Juàn Fueyo
Candelaria Gomez-Manzano
Athanassios P Kyritsis
Amendments and Corrections12 Oct 2000
Oncogene

Volume: 19, P: 5038
Oncolytic adenoviruses – selective retargeting to tumor cells

J Michael Mathis
Mariam A Stoff-Khalili
David T Curiel
Reviews21 Nov 2005
Oncogene

Volume: 24, P: 7775-7791
Oncolytic adenovirus retargeted to Delta-EGFR induces selective antiglioma activity

Y Piao
H Jiang
J Fueyo
Research17 Oct 2008
Cancer Gene Therapy

Volume: 16, P: 256-265
A deficiency in Mdm2 binding protein inhibits Myc-induced B-cell proliferation and lymphomagenesis

J Odvody
T Vincent
C M Eischen
Research22 Mar 2010
Oncogene

Volume: 29, P: 3287-3296

Search

Filter By:

Search

Quick links