Nature Search

Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

Fine-mapping of causal variants and integration of epigenetic and chromatin conformation data identify likely target genes for 150 breast cancer risk regions.

Laura Fachal
Hugues Aschard
Alison M. Dunning
Research07 Jan 2020
Nature Genetics

Volume: 52, P: 56-73
ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype

Basal-like breast cancer is a heterogeneous disease with poor prognosis; however, its cellular origins and aetiology are poorly understood. Here the authors provide evidence that ID4 is a key controller of mammary stem/progenitor cell self-renewal, acting upstream of Notch signalling to repress luminal fate commitment.

Simon Junankar
Laura A. Baker
Alexander Swarbrick
Research27 Mar 2015
Nature Communications

Volume: 6, P: 1-12
Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth

Expression of the tumour suppressor PTEN in disseminated primary tumour cells is lost after tumour cells metastasize to the brain, with downregulation instigated by microRNAs from astrocytes, which are transferred from cell to cell by exosomes; these findings reveal the dynamic nature of metastatic cancer cells when adapting to a new tissue environment.

Lin Zhang
Siyuan Zhang
Dihua Yu
Research19 Oct 2015
Nature

Volume: 527, P: 100-104
Epigenome erosion and SOX10 drive neural crest phenotypic mimicry in triple-negative breast cancer

Jodi M. Saunus
Xavier M. De Luca
Sunil R. Lakhani
ResearchOpen Access02 May 2022
npj Breast Cancer

Volume: 8, P: 1-16
Correction: DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer

S. Hernández-Pérez
E. Cabrera
R. Freire
Amendments and Corrections08 May 2019
Oncogene

Volume: 38, P: 4886
Mendelian randomisation study of smoking exposure in relation to breast cancer risk

Hanla A. Park
Sonja Neumeyer
Jenny Chang-Claude
ResearchOpen Access02 Aug 2021
British Journal of Cancer

Volume: 125, P: 1135-1145
CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers

Nichola Johnson
Sarah Maguire
Olivia Fletcher
ResearchOpen Access26 Jan 2021
British Journal of Cancer

Volume: 124, P: 842-854
The mutational landscape of melanoma brain metastases presenting as the first visceral site of recurrence

Roy Rabbie
Peter Ferguson
David J. Adams
ResearchOpen Access07 Oct 2020
British Journal of Cancer

Volume: 124, P: 156-160
Erratum: Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer

F Al-Ejeh
P T Simpson
K K Khanna
Amendments and Corrections27 Oct 2014
Oncogenesis

Volume: 3, P: e124
LobSig is a multigene predictor of outcome in invasive lobular carcinoma

Amy E. McCart Reed
Samir Lal
Peter T. Simpson
ResearchOpen Access27 Jun 2019
npj Breast Cancer

Volume: 5, P: 1-11
Erratum: DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer

S Hernández-Pérez
E Cabrera
R Freire
Amendments and Corrections26 Jun 2017
Oncogene

Volume: 36, P: 4817
The calcium pump plasma membrane Ca²⁺-ATPase 2 (PMCA2) regulates breast cancer cell proliferation and sensitivity to doxorubicin

Amelia A. Peters
Michael J. G. Milevskiy
Gregory R. Monteith
ResearchOpen Access05 May 2016
Scientific Reports

Volume: 6, P: 1-13
DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer

S Hernández-Pérez
E Cabrera
R Freire
Research13 Mar 2017
Oncogene

Volume: 36, P: 4802-4809
The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

Gisella Figlioli
Massimo Bogliolo
Paolo Peterlongo
ResearchOpen Access01 Nov 2019
npj Breast Cancer

Volume: 5, P: 1-14
E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium

Hisani N. Horne
Hannah Oh
Jonine D. Figueroa
ResearchOpen Access26 Apr 2018
Scientific Reports

Volume: 8, P: 1-11
FANCM missense variants and breast cancer risk: a case-control association study of 75,156 European women

Gisella Figlioli
Amandine Billaud
Paolo Peterlongo
ResearchOpen Access27 Jan 2023
European Journal of Human Genetics

Volume: 31, P: 578-587
Development and validation of a targeted gene sequencing panel for application to disparate cancers

Mark J. McCabe
Marie-Emilie A. Gauthier
Mary-Anne Young
ResearchOpen Access19 Nov 2019
Scientific Reports

Volume: 9, P: 1-16

Search

Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype

Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth

Epigenome erosion and SOX10 drive neural crest phenotypic mimicry in triple-negative breast cancer

Correction: DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer

Mendelian randomisation study of smoking exposure in relation to breast cancer risk

CYP3A71C* allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers

The mutational landscape of melanoma brain metastases presenting as the first visceral site of recurrence

Erratum: Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer

LobSig is a multigene predictor of outcome in invasive lobular carcinoma

Erratum: DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer

The calcium pump plasma membrane Ca²⁺-ATPase 2 (PMCA2) regulates breast cancer cell proliferation and sensitivity to doxorubicin

DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer

The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium

FANCM missense variants and breast cancer risk: a case-control association study of 75,156 European women

Development and validation of a targeted gene sequencing panel for application to disparate cancers

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