Schlafen 11 serves as a biomarker in cancer, a sensor of single-stranded DNA, and as an antiviral restriction factor. Here, the authors use cryo-electron microscopy and biochemical assays to explain how phosphorylation regulates Schlafen 11’s tRNA cleavage and single-stranded DNA binding activities.
- Michael Kugler
- Felix J. Metzner
- Katja Lammens