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Showing 1–4 of 4 results
Advanced filters: Author: J Slopis Clear advanced filters

  • Chimeric antigen receptor (CAR) T cell therapies have impressive activity in the treatment of cancer but are associated with potentially fatal toxicities. In light of the approval of CAR T cell therapy for paediatric patients, a panel of experts from the Hematopoietic Stem Cell Transplantation (HSCT) Subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, the CAR T Cell Therapy-Associated Toxicity (CARTOX) Program at The University of Texas MD Anderson Cancer Center, and several other institutions have developed consensus guidelines for the use and management of these treatments in paediatric patients, which are presented herein.

    • Kris M. Mahadeo
    • Sajad J. Khazal
    • Elizabeth J. Shpall
    ReviewsOpen Access
    Nature Reviews Clinical Oncology
    Volume: 16, P: 45-63

  • Soft tissue sarcomas are rare and aggressive neoplasms with limited models for laboratory-based studies. This study established eight models of soft tissue sarcomas, three malignant peripheral nerve sheath tumors, four undifferentiated pleomorphic sarcomas, and one unclassified spindle cell sarcoma. The new sarcoma cell lines are tools to elucidate molecular aberrations and improve treatment options for these difficult-to-treat sarcomas.

    • Angela D. Bhalla
    • Sharon M. Landers
    • Keila E. Torres
    Research
    Laboratory Investigation
    Volume: 102, P: 658-666