The contribution of fatty acids to Alzheimer's disease pathogenesis is unclear. The authors identify an increase in arachadonic acid and its metabolites in a mouse model for Alzheimer's disease and show that amyloid-beta (Aβ) affects phosphorylation of an isoform of phospholipase A2 (GIVA-PLA2). Inhibiting activation of GIVA-PLA2 protected against Aβ-induced toxicity and prevented some Aβ-induced deficits in learning and memory.
- Rene O Sanchez-Mejia
- John W Newman
- Lennart Mucke
