Nature Search

Structure guided functional analysis of the S. cerevisiae Mre11 complex

The Mre11-Rad50 complex, key in eukaryotic DNA damage response, was resolved at 3.2 Å by cryo-EM. The study defines critical residues for assembly and DNA binding, and shows Rad50’s coiled coil affects ATP hydrolysis over distance.

Marcel Hohl
You Yu
John Petrini
ResearchOpen Access12 Aug 2025
Nature Communications

Volume: 16, P: 1-17
Crystal structure of the HMGA AT-hook 1 domain bound to the minor groove of AT-rich DNA and inhibition by antikinetoplastid drugs

J. Jonathan Nué-Martinez
Marta Maturana
Christophe Dardonville
ResearchOpen Access30 Oct 2024
Scientific Reports

Volume: 14, P: 1-16
Hook innovation boosts foraging efficiency in tool-using crows

Although New Caledonian crows are known to create hooked foraging tools in the wild, here the authors show that this allows them to forage more efficiently compared with when they use non-hooked tools.

James J. H. St Clair
Barbara C. Klump
Christian Rutz
Research22 Jan 2018
Nature Ecology & Evolution

Volume: 2, P: 441-444
Natural Cytotoxic Antibodies in Human Blood Sera which react with Mammalian Cells and Bacteria

S. FEDOROFF
S. J. WEBB
Research06 Jan 1962
Nature

Volume: 193, P: 80-81
Mechanosensitive channel engineering: A study on the mixing and matching of YnaI and MscS sensor paddles and pores

Mechanosensitive ion channels protect bacteria from a hypoosmotic shock. Here, Flegler et al. use electron microscopy to describe the gating transition of the MscS-like channel YnaI and a chimera generated from MscS and YnaI.

Vanessa J. Flegler
Akiko Rasmussen
Bettina Böttcher
ResearchOpen Access23 Aug 2025
Nature Communications

Volume: 16, P: 1-12
Conserved function of the HAUS6 calponin homology domain in anchoring augmin for microtubule branching

Augmin is essential for microtubule nucleation during cell division. This study reveals how the conserved calponin homology domain of the augmin subunit HAUS6 binds to microtubules to orient augmin for microtubule branching.

Martin Würtz
Giulia Tonon
Stefan Pfeffer
ResearchOpen Access22 Aug 2025
Nature Communications

Volume: 16, P: 1-20
Selective posttranslational inhibition of Ca_Vβ₁-associated voltage-dependent calcium channels with a functionalized nanobody

Auxiliary subunit molecular diversity is an unexploited target for developing ion channel inhibitors. Here, the authors develop a general approach to inhibit ion channels based on the resident auxiliary subunit isoform to elucidate unique functions of distinct ion channel macromolecular complexes.

Travis J. Morgenstern
Neha Nirwan
Henry M. Colecraft
ResearchOpen Access09 Dec 2022
Nature Communications

Volume: 13, P: 1-19
Crystallization of Silver Chromate

J. R. HOWARD
G. H. NANCOLLAS
Research29 Oct 1955
Nature

Volume: 176, P: 833-834
Last Glacial and Holocene dynamics override post-colonial disturbance in shaping genetic diversity of a heavily exploited palaeoendemic conifer, Lagarostrobos franklinii

James R. P. Worth
James R. Marthick
Gregory J. Jordan
Research14 Oct 2025
Heredity

P: 1-13
Synaptic enrichment of pSer129 alpha-synuclein correlates with dopaminergic denervation in early-stage Parkinson’s disease

α-Synuclein accumulation in putaminal synapses is hypothesised to drive Parkinson’s disease progression. This study demonstrates synaptic pSer129 α-synuclein enrichment in early-stage Parkinson’s disease, and its link with dopaminergic denervation and cortical Lewy body pathology.

Irene Frigerio
Martino L. Morella
Wilma DJ van de Berg
ResearchOpen Access18 Jul 2025
Nature Communications

Volume: 16, P: 1-19
Growth of human B-lymphocyte colonies in vitro

J. RADNAY
I. GOLDMAN
L. A. ROZENSZAJN
Research01 Mar 1979
Nature

Volume: 278, P: 351-353
Transport of the Kinin, N₆-Benzyladenine: Non-Polar or Polar?

J. EUGENE FOX
JERRY S. WEIS
Research01 May 1965
Nature

Volume: 206, P: 678-679
Molecular structure of the intact bacterial flagellar basal body

The in situ cryo-electron microscopy structure of the intact Salmonella flagellar basal body—including the inner membrane rotor, drive shaft and outer membrane bushing complex—elucidates the mechanisms of assembly of this complex macromolecular structure that enables bacterial motility.

Steven Johnson
Emily J. Furlong
Susan M. Lea
Research30 Apr 2021
Nature Microbiology

Volume: 6, P: 712-721
Dynamic measurement of myosin light-chain-domain tilt and twist in muscle contraction

J. E. T. Corrie
B. D. Brandmeier
M. Irving
Research29 Jul 1999
Nature

Volume: 400, P: 425-430
Factors Controlling the Differentiation of the Hydatid Organism, Echinococcus granulosus, into Cystic or Strobilar Stages in vitro

J. D. SMYTH
A. B. HOWKINS
MARY BARTON
Research24 Sept 1966
Nature

Volume: 211, P: 1374-1377
Continuity of the Solid and the Liquid States

J. Frenkel
News03 Aug 1935
Nature

Volume: 136, P: 167-168
Computational models reveal that intuitive physics underlies visual processing of soft objects

Soft objects challenge visual processing in unique ways, yet most models of vision focus on rigid bodies. Here, the authors use computational modeling to reveal that simulation-based intuitive physics underlies human soft object perception.

Wenyan Bi
Aalap D. Shah
Ilker Yildirim
ResearchOpen Access09 Jul 2025
Nature Communications

Volume: 16, P: 1-15
The Supposed Fall of an Aërolite in Naples

H. J. JOHNSTON-LAVIS
Research17 Dec 1885
Nature

Volume: 33, P: 153
Elongation of Yeast Cells in Continuous Culture

C. M. BROWN
J. S. HOUGH
Research01 May 1965
Nature

Volume: 206, P: 676-678
Radiation Observations with Satellite 1958_δ Over Australia

A. J. HERZ
K. W. OGILVIE
R. B. WHITE
Research08 Aug 1959
Nature

Volume: 184, P: 391-395
Altered Hox expression and segmental identity in Mll-mutant mice

Benjamin D. Yu
Jay L. Hess
Stanley J. Korsmeyer
Research30 Nov 1995
Nature

Volume: 378, P: 505-508
Control of membrane barrier during bacterial type-III protein secretion

Type-III secretion systems (T3SSs) are capable of translocating proteins with high speed while maintaining the membrane barrier for small molecules. Here, a structure-function analysis of the T3SS pore complex elucidates the precise mechanisms enabling the gating and the conformational changes required for protein substrate secretion.

Svenja Hüsing
Manuel Halte
Thibaud T. Renault
ResearchOpen Access28 Jun 2021
Nature Communications

Volume: 12, P: 1-12
Cross-species comparison reveals that Hmga1 reduces H3K27me3 levels to promote cardiomyocyte proliferation and cardiac regeneration

Bouwman et al. identify Hmga1-mediated chromatin remodeling as the fundamental regulator of zebrafish cardiac regeneration and reveal the potential of Hmga1 to restore heart repair in mice by reactivating developmental genes, suggesting potential therapeutic applications.

Mara Bouwman
Dennis E. M. de Bakker
Jeroen Bakkers
ResearchOpen Access02 Jan 2025
Nature Cardiovascular Research

Volume: 4, P: 64-82
Structural basis of PROTAC cooperative recognition for selective protein degradation

The description of the crystal structure of the Brd4 PROTAC compound MZ1 in complex with the human E3 ubiquitin ligase VHL and the Brd4 bromodomain shines new light onto how PROTACs work and enables design of degraders with increased selectivity for Brd4.

Morgan S Gadd
Andrea Testa
Alessio Ciulli
Research13 Mar 2017
Nature Chemical Biology

Volume: 13, P: 514-521
Global status and conservation potential of reef sharks

Fishing has had a profound impact on global reef shark populations, and the absence or presence of sharks is strongly correlated with national socio-economic conditions and reef governance.

M. Aaron MacNeil
Demian D. Chapman
Joshua E. Cinner
Research22 Jul 2020
Nature

Volume: 583, P: 801-806
Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9

Extracellular vesicles (EVs) play a role in intercellular communication, however the precise biogenesis of different populations of EVs are not clear. Here, the authors follow the intracellular trafficking of two proteins before their secretion in EVs and report the biogenesis and protein markers of EV subtypes: ectosomes budding from the plasma membrane as well as exosomes from late endosomes.

Mathilde Mathieu
Nathalie Névo
Clotilde Théry
ResearchOpen Access19 Jul 2021
Nature Communications

Volume: 12, P: 1-18
Precambrian Africa and South America as a Single Continent

J. D. A. PIPER
J. C. BRIDEN
KEITH LOMAX
Research05 Oct 1973
Nature

Volume: 245, P: 244-248
Oxidase Activity in Ecotypic Populations of Typha Latifolia L.

S. J. MCNAUGHTON
Research24 Sept 1966
Nature

Volume: 211, P: 1377-1379
The continental drift debate

F. J. Vine
Reviews01 Mar 1977
Nature

Volume: 266, P: 19-22
Structure of the class D GPCR Ste2 dimer coupled to two G proteins

A cryo-electron microscopy structure of the yeast pheromone receptor Ste2, a class D G-protein-coupled receptor, in its active state reveals that Ste2 is a homodimer that couples to two G proteins.

Vaithish Velazhahan
Ning Ma
Christopher G. Tate
Research02 Dec 2020
Nature

Volume: 589, P: 148-153
Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation

Thierry O. Fischmann
Alan Hruza
Patricia C. Weber
Research01 Mar 1999
Nature Structural Biology

Volume: 6, P: 233-242
Passive Transfer of Adjuvant-induced Arthritis and Allergic Encephalomyelitis in Rats using Thoracic Duct Lymphocytes

DARLING J. WHITEHOUSE
M. W. WHITEHOUSE
C. M. PEARSON
Research27 Dec 1969
Nature

Volume: 224, P: 1322
Structural insights into CXCR4 modulation and oligomerization

Here, cryo-electron microscopy structures reveal how the chemokine receptor CXCR4 oligomerizes and how it is regulated by its physiological ligand CXCL12, the small-molecule drug AMD3100 and the monoclonal antibody REGN7663.

Kei Saotome
Luke L. McGoldrick
Matthew C. Franklin
ResearchOpen Access23 Sept 2024
Nature Structural & Molecular Biology

Volume: 32, P: 315-325
Immunological Significance of the Thymus of the Adult Mouse

J. F. A. P. MILLER
Research29 Sept 1962
Nature

Volume: 195, P: 1318-1319
Carnivorous sponges

J. Vacelet
N. Boury-Esnault
Research26 Jan 1995
Nature

Volume: 373, P: 333-335
Structures of the Cd44–hyaluronan complex provide insight into a fundamental carbohydrate-protein interaction

Suneale Banerji
Alan J Wright
David G Jackson
Research11 Feb 2007
Nature Structural & Molecular Biology

Volume: 14, P: 234-239
Ethylene-triggered subcellular trafficking of CTR1 enhances the response to ethylene gas

Park et al. show that upon exposure to ethylene gas, CTR1, which normally has a negative effect on ethylene signaling, translocates into the nucleus and enhances the plant’s response to ethylene by stabilizing the EIN3 transcription factor.

Hye Lin Park
Dong Hye Seo
Gyeong Mee Yoon
ResearchOpen Access23 Jan 2023
Nature Communications

Volume: 14, P: 1-15
DNA origami signal amplification in lateral flow immunoassays

Lateral flow immunoassays (LFIAs) enable a rapid detection of analytes in a simple, paper-based test format, but their low sensitivity limits their applications. Here, the authors report a DNA origami-based signal amplification technology for LFIAs and apply it for the detection of cardiac troponin I in human serum.

Heini Ijäs
Julian Trommler
Maximilian J. Urban
ResearchOpen Access04 Apr 2025
Nature Communications

Volume: 16, P: 1-10
Alleviation of 1-Aminocyclopentane-1-carboxylic Acid Toxicity by Valine

L. J. MACHLIN
R. S. GORDON
F. PUCHAL
Research06 Apr 1963
Nature

Volume: 198, P: 87-88
Antibody Production by Single Spleen Cells : a Comparative Study of the Cluster and Agar-plaque Formation

O. B. ZAALBERG
V. A. VAN DER MEUL
J. M. VAN TWISK
Research30 Apr 1966
Nature

Volume: 210, P: 544-545
Dissolved aluminium concentration in sea water

D. J. HYDES
Research14 Jul 1977
Nature

Volume: 268, P: 136-137
Hydrogel intraocular lens experience with endocapsular implantation

W J Rich
P I Condon
S P B Percival
Research01 Sept 1988
Eye

Volume: 2, P: 523-528
Sensory quiescence induces a cell-non-autonomous integrated stress response curbed by condensate formation of the ATF4 and XRP1 effectors

Chronic stress responses can be as damaging as the hazards they counteract. Here the authors show how a blindness-induced brain-wide stress response is dampened by sequestration of transcription factors in cytosolic granules.

Shashank Shekhar
Charles Tracy
Helmut Krämer
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-16
Structures of the RNA-guided surveillance complex from a bacterial immune system

Blake Wiedenheft
Gabriel C. Lander
Eva Nogales
Research21 Sept 2011
Nature

Volume: 477, P: 486-489
Substances with Fungicidal Activity in the Bark of Deciduous Trees

J. GROSJEAN
Research27 May 1950
Nature

Volume: 165, P: 853-854
Paper-based broadband flexible photodetectors with van der Waals materials

Erfan Mahmoodi
Morteza Hassanpour Amiri
Foad Ghasemi
ResearchOpen Access22 Jul 2022
Scientific Reports

Volume: 12, P: 1-12
Spermine as a Protective Agent against Osmotic Lysis

J. MAGER
Research27 Jun 1959
Nature

Volume: 183, P: 1827-1828
Interphase Deoxyribonucleic Acid Condensation, Late Deoxyribonucleic Acid Replication, and Gene Inactivation

JORGE J. YUNIS
Research16 Jan 1965
Nature

Volume: 205, P: 311-312
Timing and scintillation observations of the fast pulsar in CTB80

A. S. Fruchter
J. H. Taylor
A. Wolszczan
Research07 Jan 1988
Nature

Volume: 331, P: 53-54
The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II

Tilman Oltersdorf
Lawrence C. Fritz
Sukanto Sinha
Research14 Sept 1989
Nature

Volume: 341, P: 144-147

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