Nature Search

Worm Perturb-Seq: massively parallel whole-animal RNAi and RNA-seq

Dissecting the causal relationship between genotype and phenotype can be challenging, Here, the authors develop Worm Perturb-Seq, a high throughput sequencing and analytical framework to assess transcriptomic changes upon gene perturbation in whole C. elegans.

Hefei Zhang
Xuhang Li
Albertha J. M. Walhout
ResearchOpen Access23 May 2025
Nature Communications

Volume: 16, P: 1-21
Coordinated adaptations define the ontogenetic shift from worm- to fish-hunting in a venomous cone snail

Challenges rearing juvenile cone snails have limited our understanding of their developmental biology. This study cultured Conus magus cone snails and revealed how complex morphological, behavioural and molecular changes facilitate the ontogenetic shift from juvenile worm-hunters to fish-hunting adults.

Aymeric Rogalski
S. W. A. Himaya
Richard J. Lewis
ResearchOpen Access13 Jun 2023
Nature Communications

Volume: 14, P: 1-11
Worm scientist's identity revealed

Mark J. F. Brown
Correspondence15 Jun 2011
Nature

Volume: 474, P: 285
Control of the Army Worm on Grazing in Kenya

J. A. BULLOCK
D. C. BOND
Research04 Nov 1961
Nature

Volume: 192, P: 480-481
The Glow-worm

J. SHAW
Research06 Jan 1876
Nature

Volume: 13, P: 188
An Insect Attacking a Worm

J. SHAW
Research12 Oct 1882
Nature

Volume: 26, P: 574
Tape-worm of Rabbits

GEORGE J. ROMANES
Research01 Mar 1877
Nature

Volume: 15, P: 375
Mechanoresponsive lipid-protein nanoglobules facilitate reversible fibre formation in velvet worm slime

Velvet worms expel a fluid slime that, under shear force, forms stiff fibres that can be dissolved and then regenerated. Here, the authors reveal that the recyclability of these biopolymers relies on mechanoresponsive lipid-protein nanoglobules in the slime that reversibly self-assemble into fibrils.

Alexander Baer
Stephan Schmidt
Matthew J. Harrington
ResearchOpen Access17 Oct 2017
Nature Communications

Volume: 8, P: 1-7
iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human

Daniele Bergamaschi
Yardena Samuels
Xin Lu
Research13 Jan 2003
Nature Genetics

Volume: 33, P: 162-167
A lysosomal surveillance response to stress extends healthspan

Li et al. uncover a lysosomal surveillance response whereby intestinal lumen deacidification induces a transcriptional programme that boosts lysosomal activity and improves protein aggregate clearance in multiple worm disease models, extending healthspan.

Terytty Yang Li
Arwen W. Gao
Johan Auwerx
ResearchOpen Access26 Jun 2025
Nature Cell Biology

Volume: 27, P: 1083-1097
Tissue-specific profiling of age-dependent miRNAomic changes in Caenorhabditis elegans

Wang et al. profile age-dependent miRNAomic changes in worm tissues and extracellular vesicles (EVs). They show that ageing controls miRNAs in a tissue-specific manner and their findings further suggest a complex EV-mediated miRNA trafficking network across tissues.

Xueqing Wang
Quanlong Jiang
Yidong Shen
ResearchOpen Access01 Feb 2024
Nature Communications

Volume: 15, P: 1-16
An open-source platform for analyzing and sharing worm-behavior data

Avelino Javer
Michael Currie
André E. X. Brown
Correspondence31 Aug 2018
Nature Methods

Volume: 15, P: 645-646
T cell responses in repeated controlled human schistosome infection compared to natural exposure

In schistosomiasis-endemic regions, the cyclical nature of infection and treatment complicates understanding of host immune responses. Repeated controlled human Schistosoma mansoni infection, designed to reflect the reinfection cycles common in endemic areas, shows that repeated exposure induces mixed worm-specific CD4⁺ T cell responses similar to those seen in endemic infection.

Emmanuella Driciru
Jan Pieter R. Koopman
Emma L. Houlder
ResearchOpen Access24 Jul 2025
Nature Communications

Volume: 16, P: 1-11
Dogs and the classic route of Guinea Worm transmission: an evaluation of copepod ingestion

Kayla B. Garrett
Erin K. Box
Michael J. Yabsley
ResearchOpen Access29 Jan 2020
Scientific Reports

Volume: 10, P: 1-5
But is man a worm?

J. S. Jones
Books & Arts26 Aug 1982
Nature

Volume: 298, P: 873-874
Global diversity of soil-transmitted helminths reveals population-biased genetic variation that impacts diagnostic targets

This study analysed genetic data of soil-transmitted helminths from 27 countries, revealing diversity impacting molecular test accuracy and highlighting the need to adapt diagnostics for effective STH surveillance.

Marina Papaiakovou
Andrea Waeschenbach
Stephen R. Doyle
ResearchOpen Access10 Jul 2025
Nature Communications

Volume: 16, P: 1-13
Miners' Worm ¹

SYDNEY J. HICKSON
News08 Feb 1906
Nature

Volume: 73, P: 344
Worm holes and avian space-time

Can animals remember where and when events happened? A study of birds that hoard and then retrieve their food shows that they can, and may ultimately provide clues about how human memories are formed.

Kathryn Jeffery
John O'Keefe
News & Views17 Sept 1998
Nature

Volume: 395, P: 215-216
Optogenetic manipulation of neural activity in freely moving Caenorhabditis elegans

An optogenetic illumination system based on the use of a digital micromirror device and video tracking software is reported, which allows real-time light delivery with high spatial resolution to specified targets in freely moving Caenorhabditis elegans. Also in this issue, Stirman et al. report a similar illumination system using a liquid crystal display projector. Both methods allow optogenetic perturbation of a variety of neural circuits in the behaving worm.

Andrew M Leifer
Christopher Fang-Yen
Aravinthan D T Samuel
Research16 Jan 2011
Nature Methods

Volume: 8, P: 147-152
A TFEB–TGFβ axis systemically regulates diapause, stem cell resilience and protects against a senescence-like state

Nonninger et al. identify the TFEB–TGFβ signaling axis as a regulator of stem cell resilience that protects against a senescence-like state during the adult diapause in Caenorhabditis elegans, a mechanism conserved in vertebrate aging and mammalian cancer.

Tim J. Nonninger
Jennifer Mak
Adam Antebi
ResearchOpen Access30 Jun 2025
Nature Aging

Volume: 5, P: 1340-1357
The precursor of PI(3,4,5)P₃ alleviates aging by activating daf-18(Pten) and independent of daf-16

Phosphatidylinositol 3-kinase catalyzes the reaction from PI(4,5)P₂ to PI(3,4,5)P₃ and is encoded by the age-1 gene known to regulate lifespan. Here the researchers found that the metabolite myo-inositol, which can be converted to PI(3,4,5)P₃ extends worm lifespan and alleviates worm as well as mouse health decline during aging.

Dawei Shi
Xian Xia
Jing-Dong J. Han
ResearchOpen Access08 Sept 2020
Nature Communications

Volume: 11, P: 1-12
Genetic and morphological identification of filarial worm from Iberian hare in Portugal

F. A. Abade dos Santos
M. D. Duarte
J. Gomes
ResearchOpen Access03 Jun 2022
Scientific Reports

Volume: 12, P: 1-15
The circadian regulator BMAL1 programmes responses to parasitic worm infection via a dendritic cell clock

Thomas W. Hopwood
Sarah Hall
Kathryn J. Else
ResearchOpen Access28 Feb 2018
Scientific Reports

Volume: 8, P: 1-13
Capturing the continuous complexity of behaviour in Caenorhabditis elegans

Animal behaviour is characterized by repeated movements which can be difficult to analyse quantitatively. Here, the authors apply a data-driven framework based on theory of dynamical systems to characterize nematode behaviour and explain its complexity through deterministic chaotic dynamics.

Tosif Ahamed
Antonio C. Costa
Greg J. Stephens
Research05 Oct 2020
Nature Physics

Volume: 17, P: 275-283
The parasitic worm-derived immunomodulator, ES-62 and its drug-like small molecule analogues exhibit therapeutic potential in a model of chronic asthma

J. C. Coltherd
D. T. Rodgers
M. M. Harnett
ResearchOpen Access14 Jan 2016
Scientific Reports

Volume: 6, P: 1-14
Validation of ultrasound bioimaging to predict worm burden and treatment efficacy in preclinical filariasis drug screening models

Amy E. Marriott
Hanna Sjoberg
Joseph D. Turner
ResearchOpen Access12 Apr 2018
Scientific Reports

Volume: 8, P: 1-10
Identification of oxadiazoles as new drug leads for the control of schistosomiasis

Ahmed A Sayed
Anton Simeonov
David L Williams
Research16 Mar 2008
Nature Medicine

Volume: 14, P: 407-412
Small Molecule Analogues of the parasitic worm product ES-62 interact with the TIR domain of MyD88 to inhibit pro-inflammatory signalling

Colin J. Suckling
Shahabuddin Alam
William Harnett
ResearchOpen Access01 Feb 2018
Scientific Reports

Volume: 8, P: 1-11
A rationally designed bicyclic peptide remodels Aβ42 aggregation in vitro and reduces its toxicity in a worm model of Alzheimer’s disease

Tatsuya Ikenoue
Francesco A. Aprile
Michele Vendruscolo
ResearchOpen Access17 Sept 2020
Scientific Reports

Volume: 10, P: 1-15
The search for an elusive worm in the tropics, the past as a key to the present, and reverse uniformitarianism

Luis I. Quiroz
Luis A. Buatois
Andrew J. Sellers
ResearchOpen Access05 Dec 2019
Scientific Reports

Volume: 9, P: 1-8
Antigenic Relationship Between Host and Parasite

J. K. DINEEN
Research02 Feb 1963
Nature

Volume: 197, P: 471-472
Seasonal variation in UVA light drives hormonal and behavioural changes in a marine annelid via a ciliary opsin

The intensity of UVA light, in addition to the photoperiod, is shown to determine seasonal change in the marine mass spawning annelid Platynereis dumerilii.

Vinoth Babu Veedin Rajan
N. Sören Häfker
Kristin Tessmar-Raible
Research11 Jan 2021
Nature Ecology & Evolution

Volume: 5, P: 204-218
Locomotion of an untethered, worm-inspired soft robot driven by a shape-memory alloy skeleton

Lin Xu
Robert J. Wagner
Franck J. Vernerey
ResearchOpen Access20 Jul 2022
Scientific Reports

Volume: 12, P: 1-16
Predicting the risk and speed of drug resistance emerging in soil-transmitted helminths during preventive chemotherapy

Resistance to chemotherapy for soil-transmitted helminth infection has been detected in veterinary settings but not yet in human infections. Here, the authors investigate the risk of resistance in humans and how it may change as a result of scaling-up preventative deworming programs.

Luc E. Coffeng
Wilma A. Stolk
Sake J. de Vlas
ResearchOpen Access06 Feb 2024
Nature Communications

Volume: 15, P: 1-11
Dendritic cells provide a therapeutic target for synthetic small molecule analogues of the parasitic worm product, ES-62

Felicity E. Lumb
James Doonan
William Harnett
ResearchOpen Access10 May 2017
Scientific Reports

Volume: 7, P: 1-13
Heat shock proteins function as signaling molecules to mediate neuron–glia communication in C. elegans during aging

Glia–neuron interactions are highly complex. Glial cells can sense and modulate different aspects of neuronal activity. Here in Caenorhabditis elegans, the authors show that early aged sensory neurons can transfer proteins via extracellular vesicles to AMsh glia, inducing neuroprotection during aging.

Jieyu Wu
Victoria R. Yarmey
Dong Yan
Research18 Jun 2025
Nature Neuroscience

Volume: 28, P: 1635-1648
Rhesus macaques self-curing from a schistosome infection can display complete immunity to challenge

To date there is only one single drug with modest efficacy and no vaccine available to protect from schistosomiasis. Here, Amaral et al. characterize the self-cure process of rhesus macaques following primary infection and secondary challenge with Schistosoma mansoni to inform future vaccine development studies.

Murilo Sena Amaral
Daisy Woellner Santos
Sergio Verjovski-Almeida
ResearchOpen Access26 Oct 2021
Nature Communications

Volume: 12, P: 1-17
Herbal terpenoids activate autophagy and mitophagy through modulation of bioenergetics and protect from metabolic stress, sarcopenia and epigenetic aging

Using a zebrafish-based screen, Civiletto and colleagues identify the herb-derived metabolites thymol and carvacrol as activators of autophagy and mitophagy, demonstrating their therapeutic potential in C. elegans and mouse models.

Gabriele Civiletto
Dario Brunetti
Philipp Gut
ResearchOpen Access24 Sept 2025
Nature Aging

P: 1-19
Nature of the Tryptophanase Complex

E. A. DAWES
J. DAWSON
F. C. HAPPOLD
Research10 May 1947
Nature

Volume: 159, P: 644-645
Gross Structure of Hæmoglobin A₃ and the Nature of its Binding to Chromium-51

H. A. PEARSON
M. T. VAN METRE
K. M. VERTREES
Research02 Feb 1963
Nature

Volume: 197, P: 472-473
Bacterial c-di-GMP has a key role in establishing host–microbe symbiosis

The bacterial second messenger c-di-GMP is important for host association of microbes in C. elegans and beyond.

Nancy Obeng
Anna Czerwinski
Hinrich Schulenburg
ResearchOpen Access31 Aug 2023
Nature Microbiology

Volume: 8, P: 1809-1819
Erratum: An asthma-associated genetic variant of STAT6 predicts low burden of ascaris worm infestation

G Peisong
X-Q Mao
J M Hopkin
Amendments and Corrections26 Jan 2005
Genes & Immunity

Volume: 6, P: 70
An asthma-associated genetic variant of STAT6 predicts low burden of ascaris worm infestation

G Peisong
X-Q Mao
J M Hopkin
Research21 Jan 2004
Genes & Immunity

Volume: 5, P: 58-62
Parallel pathways for serotonin biosynthesis and metabolism in C. elegans

Untargeted comparative metabolomics revealed serotonin biosynthesis and metabolism pathways in nonneuronal tissues that contribute to established serotonin-dependent phenotypes in C. elegans.

Jingfang Yu
Merly C. Vogt
Frank C. Schroeder
Research10 Oct 2022
Nature Chemical Biology

Volume: 19, P: 141-150
Author Correction: Genetic and morphological identification of filarial worm from Iberian hare in Portugal

F. A. Abade dos Santos
M. D. Duarte
J. Gomes
Amendments and CorrectionsOpen Access25 Nov 2022
Scientific Reports

Volume: 12, P: 1
Symbiosis insights through metagenomic analysis of a microbial consortium

Tanja Woyke
Hanno Teeling
Nicole Dubilier
Research17 Sept 2006
Nature

Volume: 443, P: 950-955
An image analysis toolbox for high-throughput C. elegans assays

The freely available WormToolbox enables high-throughput image analysis of a variety of phenotypes of Caenorhabditis elegans in liquid culture and should prove useful for image-based screens.

Carolina Wählby
Lee Kamentsky
Anne E Carpenter
Research22 Apr 2012
Nature Methods

Volume: 9, P: 714-716
Reagin-Like Antibodies in Experimental Infections of Schistosoma mansoni and the Passive Transfer of Resistance

BRIDGET M. OGILVIE
S. R. SMITHERS
R. J. TERRY
Research19 Mar 1966
Nature

Volume: 209, P: 1221-1223
Polyketide synthase-derived sphingolipids mediate microbiota protection against a bacterial pathogen in C. elegans

Here, Peters et al. report that Pseudomonas fluorescens protects Caenorhabditis elegans against pathogen infection via polyketide synthase-derived sphingolipids, uncovering a non-canonical bacterial sphingolipid synthesis pathway that modulates host metabolism.

Lena Peters
Moritz Drechsler
Katja Dierking
ResearchOpen Access03 Jun 2025
Nature Communications

Volume: 16, P: 1-18
Phosphoglycolate phosphatase homologs act as glycerol-3-phosphate phosphatase to control stress and healthspan in C. elegans

Glycerol-3-phosphate phosphatase is a recently discovered enzyme at the heart of metabolism. Here, the authors used C. elegans and showed that its activation promotes stress resistance, healthy aging and acts as a calorie restriction mimetic at normal food intake without altering fertility.

Elite Possik
Clémence Schmitt
Marc Prentki
ResearchOpen Access11 Jan 2022
Nature Communications

Volume: 13, P: 1-17

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