Chiuppesi et al. demonstrate that COVID-19 vaccine COH04S1, harboring a synthetic modified vaccinia Ankara-vector, elicits cross-reactive responses against mpox virus (MPXV) similar to those induced by FDA-approved mpox vaccine JYNNEOS in healthy adults and non-human primates. COH04S1 also confers protective immunity against MPXV in a mouse model of mpox.
- Flavia Chiuppesi
- John A. Zaia
- Don J. Diamond
