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Showing 51–87 of 87 results

Advanced filters: Author: J. A. SPINK Clear advanced filters

Myosin VI: an innovative motor that challenged the swinging lever arm hypothesis

The swinging lever arm model of myosin movement was challenged by myosin VI, which takes larger steps along actin filaments than its structure seems to allow. Myosin VI achieves this by using a 180° lever arm swing and special structural features in its tail.

James A. Spudich
Sivaraj Sivaramakrishnan
Reviews01 Feb 2010
Nature Reviews Molecular Cell Biology

Volume: 11, P: 128-137
Allen's Commercial Organic Analysis

J. REILLY
Books & Arts24 Jan 1925
Nature

Volume: 115, P: 114-115
Die Ernährung der Wassertiere und der Stoffhaushalt der Gewasser

J. J.
Books & Arts07 Jul 1910
Nature

Volume: 84, P: 5
Sanitation in India ¹

J. W. W. S.
News18 Mar 1915
Nature

Volume: 95, P: 77-78
Long single α-helical tail domains bridge the gap between structure and function of myosin VI

Benjamin J Spink
Sivaraj Sivaramakrishnan
James A Spudich
Research30 May 2008
Nature Structural & Molecular Biology

Volume: 15, P: 591-597
A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis

Anders Molven and colleagues show that a recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis. The hybrid allele is associated with approximately fivefold-higher risk of disease, and it encodes a protein with reduced lipolytic activity and prominent intracellular accumulation.

Karianne Fjeld
Frank Ulrich Weiss
Anders Molven
Research16 Mar 2015
Nature Genetics

Volume: 47, P: 518-522
Genetic and biological drivers of prostate cancer disparities in Black men

Genetic and ancestral factors, molecular pathways involving androgen and non-androgen receptor signalling, inflammation, epigenetics, the tumour microenvironment and tumour metabolism are posited as biological factors that potentially contribute to racial disparities in Black men with prostate cancer.

Jun Gong
Daniel M. Kim
Stephen J. Freedland
Reviews14 Nov 2023
Nature Reviews Urology

Volume: 21, P: 274-289
High Polymer, Colloid and Surface Chemistry

W. G. P. ROBERTSON
J. R. URWIN
News09 Nov 1957
Nature

Volume: 180, P: 959-961
Quantitative Aspects of Blood Coagulation in the Generalized Shwartzman Reaction: 1. Effects of Variation of Preparative and Provocative Doses of E. Coli Endotoxin

J J Corrigan Jr.
C F Abildgaard
I Schulman
Research01 Jan 1967
Pediatric Research

Volume: 1, P: 39-49
Zoological Sketches Zoological Notes on the Structure, Affinities, Habits, and Mental Faculties of Wild and Domestic Animals; with Anecdotes concerning and Adventures among them; and some Account of their Fossil Representatives

GEORGE J. ROMANES
Books & Arts01 Feb 1883
Nature

Volume: 27, P: 333-335
Illusions

GEORGE J. ROMANES
Books & Arts30 Jun 1881
Nature

Volume: 24, P: 185-188
The past, present and potential for microfluidic reactor technology in chemical synthesis

The successes and failures of past research in the development of microfluidic reactors for chemical synthesis are highlighted. Current roadblocks are assessed and a series of challenges for the future of this area are identified.

Katherine S. Elvira
Xavier Casadevall i Solvas
Andrew J. deMello
Reviews13 Oct 2013
Nature Chemistry

Volume: 5, P: 905-915
Putative functions of tissue kallikrein-related peptidases in vaginal fluid

Proteomic and biochemical studies on cervical-vaginal fluid (CVF) have revealed that it contains several members of the tissue kallikrein-related peptidase (KLK) family. The roles of KLKs in the lower female reproductive system are not fully understood. In this Review, Muytjens and colleagues discuss the putative roles of KLKs in vaginal fluid and how increased understanding of their function could result in new diagnostic and therapeutic modalities.

Carla M. J. Muytjens
Stella K. Vasiliou
Eleftherios P. Diamandis
Reviews07 Sept 2016
Nature Reviews Urology

Volume: 13, P: 596-607
A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner

Rapid clearance frequently complicates therapeutic use of proteins and peptides. Schellenberger et al. demonstrate that genetic fusion of an unstructured polypeptide offers a general strategy to extend peptide or protein half-life in vivo in a tunable manner.

Volker Schellenberger
Chia-wei Wang
Willem P C Stemmer
Research15 Nov 2009
Nature Biotechnology

Volume: 27, P: 1186-1190
Realistic wave-optics simulation of X-ray phase-contrast imaging at a human scale

Yongjin Sung
W. Paul Segars
Rajiv Gupta
ResearchOpen Access14 Jul 2015
Scientific Reports

Volume: 5, P: 1-10
Expression of human cationic trypsinogen (PRSS1) in murine acinar cells promotes pancreatitis and apoptotic cell death

T Athwal
W Huang
N Vlatković
ResearchOpen Access10 Apr 2014
Cell Death & Disease

Volume: 5, P: e1165
Poly(A) RT–PCR measurement of diagnostic genes in pancreatic juice in pancreatic cancer

M Oliveira-Cunha
R J Byers
A K Siriwardena
ResearchOpen Access18 Jan 2011
British Journal of Cancer

Volume: 104, P: 514-519
Discrimination of suballeles present at the TNFd microsatellite locus using induced heteroduplex analysis

C F Spink
L J Keen
J L Bidwell
Research21 Jan 2004
Genes & Immunity

Volume: 5, P: 76-79
Lentiviruses in gene therapy clinical research

J B Connolly
Research29 Nov 2002
Gene Therapy

Volume: 9, P: 1730-1734
7-Bromoindirubin-3′-oxime induces caspase-independent cell death

J Ribas
K Bettayeb
L Meijer
Research15 May 2006
Oncogene

Volume: 25, P: 6304-6318
Epigenetic Silencing of the Key Antioxidant Enzyme Catalase in Karyotypically Abnormal Human Pluripotent Stem Cells

Mikko Konki
Kalyan Pasumarthy
Riikka J. Lund
ResearchOpen Access25 Feb 2016
Scientific Reports

Volume: 6, P: 1-8
Local facial cutaneous vasoconstriction: an unusual complication of inhaled racemic epinephrine in a neonate

B-OS Bengtsson
L A Spink
J B Grone
Research26 Nov 2013
Journal of Perinatology

Volume: 33, P: 985-986
Cytokine gene polymorphism in human disease: on-line databases, Supplement 1

J Bidwell
L Keen
S D’Alfonso
Reviews18 Apr 2001
Genes & Immunity

Volume: 2, P: 61-70
Contribution of the 15 amino acid repeats of truncated APC to β-catenin degradation and selection of APC mutations in colorectal tumours from FAP patients

E M Kohler
K Brauburger
J Schneikert
Research07 Dec 2009
Oncogene

Volume: 29, P: 1663-1671
Subthreshold diode micropulse panretinal photocoagulation for proliferative diabetic retinopathy

J K Luttrull
D C Musch
C A Spink
Research09 Feb 2007
Eye

Volume: 22, P: 607-612
Autocrine induction of invasion and metastasis by tumor-associated trypsin inhibitor in human colon cancer cells

V Gouyer
D Fontaine
G Huet
Research03 Mar 2008
Oncogene

Volume: 27, P: 4024-4033
Genetic and metabolic determinants of methotrexate-induced mucositis in pediatric acute lymphoblastic leukemia

M A H den Hoed
E Lopez-Lopez
M M van den Heuvel-Eibrink
Research04 Nov 2014
The Pharmacogenomics Journal

Volume: 15, P: 248-254
Genomic complexity of urothelial bladder cancer revealed in urinary cfDNA

Fiona S Togneri
Douglas G Ward
Richard T Bryan
ResearchOpen Access13 Jan 2016
European Journal of Human Genetics

Volume: 24, P: 1167-1174
Refining the relation between ‘first hits’ and ‘second hits’ at the APC locus: the ‘loose fit’ model and evidence for differences in somatic mutation spectra among patients

Michael Crabtree
Oliver M Sieber
Ian P M Tomlinson
Research02 Jul 2003
Oncogene

Volume: 22, P: 4257-4265
Identification of cJun-responsive genes in Rat-1a cells using multiple techniques: increased expression of stathmin is necessary for cJun-mediated anchorage-independent growth

Ichiro Kinoshita
Virna Leaner
Michael J Birrer
Research09 May 2003
Oncogene

Volume: 22, P: 2710-2722
Explainable AI reveals changes in skin microbiome composition linked to phenotypic differences

Anna Paola Carrieri
Niina Haiminen
Edward O. Pyzer-Knapp
ResearchOpen Access25 Feb 2021
Scientific Reports

Volume: 11, P: 1-18
Gene Therapy Progress and Prospects: Bringing gene therapy into medical practice: the evolution of international ethics and the regulatory environment

J Spink
D Geddes
Reviews23 Sept 2004
Gene Therapy

Volume: 11, P: 1611-1616
Conditionally replicating viruses in cancer therapy

J B Connolly
Research11 Apr 2003
Gene Therapy

Volume: 10, P: 712-715
Will rising prices and budget constraints prevent patients from accessing novel gene therapies?

A Kent
J Spink
Comments & Opinion07 Sept 2017
Gene Therapy

Volume: 24, P: 542-543
Reply to Dr Kumar et al

J K Luttrull
D Musch
C Spink
Correspondence16 Jan 2009
Eye

Volume: 23, P: 2123
Prognostic value of PTEN loss in men with conservatively managed localised prostate cancer

J Cuzick
Z H Yang
Z Sangale
ResearchOpen Access21 May 2013
British Journal of Cancer

Volume: 108, P: 2582-2589
Long-term outcome among men with conservatively treated localised prostate cancer

J Cuzick
G Fisher
P Scardino
ResearchOpen Access31 Oct 2006
British Journal of Cancer

Volume: 95, P: 1186-1194

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