Even though heterogeneous nuclear ribonucleoprotein C (hnRNP C) is among the most abundant proteins in the nucleus, its role in splicing has remained unresolved. Data obtained using a newly developed individual-nucleotide UV crosslinking and immunoprecipitation (iCLIP) technique, integrated with alternative splicing profiles, indicate how the position of hnRNP particles determines their effect on inclusion of alternative exons.
- Julian König
- Kathi Zarnack
- Jernej Ule
