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Showing 1–2 of 2 results
Advanced filters: Author: J. Trae Hampton Clear advanced filters

  • Gram-positive bacterial envelopes comprise proteinaceous surface layers (S-layers) important for survival and virulence that are often anchored to the cell wall through secondary cell wall polymers. Here the authors use a structural and biophysical approach to define the molecular mechanism of this important interaction.

    • Ryan J. Blackler
    • Arturo López-Guzmán
    • Stephen V. Evans
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • Most epigenetic regulator inhibitors target tunnels of active sites, rather than the peptide binding groove, leading to concerns with low selectivity. Here the authors use an amber obligate phage library to rapidly identify isoform-selective inhibitors of SIRT2.

    • Jeffery M. Tharp
    • J. Trae Hampton
    • Wenshe Ray Liu
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14