In mammals, two major non-centromeric histone H3 (H3.1/2 and H3.3) variants, display distinct nuclear distribution patterns across the genome and use distinct deposition pathways. Here the authors reveal insights on the nuclear distribution of H3.1 and H3.3 variants, focusing on their relative enrichment at chromocenters throughout the cell cycle and in different cellular states.
- S. Arfè
- T. Karagyozova
- G. Almouzni