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Showing 1–50 of 53 results

Advanced filters: Author: JA Houston Clear advanced filters

Intrathecal administration of 4-aminopyridine in chronic spinal injured patients

JA Halter
AR Blight
O Calvillo
Research12 Jan 2001
Spinal Cord

Volume: 38, P: 728-732
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Suppression of the immune response to an adenovirus vector and enhancement of intratumoral transgene expression by low-dose etoposide

M Bouvet
B Fang
JA Roth
Research07 Apr 1998
Gene Therapy

Volume: 5, P: 189-195
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Mitochondria localization induced self-assembly of peptide amphiphiles for cellular dysfunction

Spatiotemporal control of intracellular molecular self-assembly holds promise for therapeutic applications. Here the authors develop a peptide consisting of a phenylalanine dipeptide with a mitochondrial targeting moiety to form self-assembling fibrous nanostructures within mitochondria, leading to apoptosis.

M. T. Jeena
L. Palanikumar
Ja-Hyoung Ryu
ResearchOpen Access21 Jun 2017
Nature Communications

Volume: 8, P: 1-10
Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: possible sites for intervention with anti-neoplastic drugs

WL Blalock
C Weinstein-Oppenheimer
JA McCubrey
Reviews09 Aug 1999
Leukemia

Volume: 13, P: 1109-1166
Tropifexor for nonalcoholic steatohepatitis: an adaptive, randomized, placebo-controlled phase 2a/b trial

The FLIGHT-FXR trial, testing farnesoid X receptor agonist tropifexor in nonalcoholic steatohepatitis, demonstrated sustained decreases in alanine aminotransferase levels and hepatic fat fraction, but not aspartate aminotransferase, with dose-dependent pruritus being the most common adverse event.

Arun J. Sanyal
Patricia Lopez
Clifford A. Brass
ResearchOpen Access16 Feb 2023
Nature Medicine

Volume: 29, P: 392-400
Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance

Alternative lengthening of telomeres (ALT) provides cancer cells a mechanism to sustain replicative immortality. Here, the authors identify KDM2A as a molecular vulnerability in ALT-dependent cancer cells and demonstrate its role in the resolution of ALT-specific telomere clusters via recruitment of SENP6.

Fei Li
Yizhe Wang
Hongwu Zheng
ResearchOpen Access29 Mar 2023
Nature Communications

Volume: 14, P: 1-16
A retrospective study of high mobility group protein I(Y) as progression marker for prostate cancer determined by in situ hybridization

Y Tamimi
HG van der Poel
JA Schalken
Research01 Aug 1996
British Journal of Cancer

Volume: 74, P: 573-578
Intravenous infusion of 4-AP in chronic spinal cord injured subjects

WH Donovan
JA Halter
JR Strayer
Research11 Apr 2000
Spinal Cord

Volume: 38, P: 7-15
The promoter of the mouse tissue transglutaminase gene directs tissue-specific, retinoid-regulated and apoptosis-linked expression

László Nagy
Vilmos A Thomázy
Peter JA Davies
Research01 Oct 1997
Cell Death & Differentiation

Volume: 4, P: 534-547
Intercellular trafficking of VP22-GFP fusion proteins is not observed in cultured mammalian cells

B Fang
B Xu
JA Roth
Research14 Oct 1998
Gene Therapy

Volume: 5, P: 1420-1424
Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy

FXR1P is a RNA binding protein involved in muscle development. Here, the authors show that mutations in FXR1 exon 15, which is alternatively spliced in muscle, cause multi-minicore myopathy in humans and in mouse models.

María Cristina Estañ
Elisa Fernández-Núñez
Victor L. Ruiz-Perez
ResearchOpen Access15 Feb 2019
Nature Communications

Volume: 10, P: 1-19
Autophosphorylation of Src and Yes blocks their inactivation by Csk phosphorylation

Gongqin Sun
Ajay K Sharma
Raymond JA Budde
Research22 Sept 1998
Oncogene

Volume: 17, P: 1587-1595
Induction of apoptosis and differentiation by fludarabine in human leukemia cells (U937): interactions with the macrocyclic lactone bryostatin 1

JA Vrana
Z Wang
S Grant
Research22 Jul 1999
Leukemia

Volume: 13, P: 1046-1055
HMGB1 induces hepcidin upregulation in astrocytes and causes an acute iron surge and subsequent ferroptosis in the postischemic brain

Dashdulam Davaanyam
Hahnbi Lee
Ja-Kyeong Lee
ResearchOpen Access01 Nov 2023
Experimental & Molecular Medicine

Volume: 55, P: 2402-2416
Drug Insight: the role of statins in combination with ezetimibe to lower LDL cholesterol

The cardiovascular benefits of statin therapy are well documented; however, no trial has identified a target level for LDL cholesterol below which no further benefit of treatment is seen. With the introduction of more-aggressive optional LDL-cholesterol targets in US guidelines, Antonio Gotto and John Farmer consider the rationale for combination therapy of statins with the cholesterol absorption inhibitor ezetimibe.

Antonio M Gotto Jr
John A Farmer
Reviews01 Dec 2006
Nature Clinical Practice Cardiovascular Medicine

Volume: 3, P: 664-672
Expression of tissue transglutaminase in the developing chicken limb is associated both with apoptosis and endochondral ossification

Vilmos A Thomázy
Peter JA Davies
Research28 Jan 1999
Cell Death & Differentiation

Volume: 6, P: 146-154
Are capecitabine and oxaliplatin as effective as fluorouracil and cisplatin for gastroesophageal cancer?

Jaffer A Ajani
Comments & Opinion17 Jun 2008
Nature Clinical Practice Gastroenterology & Hepatology

Volume: 5, P: 414-415
Hepatocyte activation and liver injury following cerebral ischemia promote HMGB1-mediated hepcidin upregulation in hepatocytes and regulation of systemic iron levels

Dashdulam Davaanyam
Song-I Seol
Ja-Kyeong Lee
ResearchOpen Access01 Oct 2024
Experimental & Molecular Medicine

Volume: 56, P: 2171-2183
Is the addition of cisplatin to S-1 better than S-1 alone for patients with advanced gastroesophageal cancer?

Jaffer A Ajani
Comments & Opinion15 Jul 2008
Nature Clinical Practice Oncology

Volume: 5, P: 508-509
Monitoring adenoviral p53 transduction efficiency by yeast functional assay

M Tada
S Sakuma
JA Roth
Research29 Apr 1998
Gene Therapy

Volume: 5, P: 339-344
SIRT1 ISGylation accelerates tumor progression by unleashing SIRT1 from the inactive state to promote its deacetylase activity

Ji An Kang
Yoon Jung Kim
Young Joo Jeon
ResearchOpen Access05 Mar 2024
Experimental & Molecular Medicine

Volume: 56, P: 656-673
Hedgehog signalling is involved in acquired resistance to KRAS^G12C inhibitors in lung cancer cells

Chaeyoung Lee
Jawoon Yi
Jeong Woo Park
ResearchOpen Access16 Jan 2024
Cell Death & Disease

Volume: 15, P: 1-11
Effective protection of photoreceptors using an inflammation-responsive hydrogel to attenuate outer retinal degeneration

Hyerim Kim
Hyeonhee Roh
Seung Ja Oh
ResearchOpen Access14 Dec 2023
npj Regenerative Medicine

Volume: 8, P: 1-17
Gene transfer of costimulatory molecules B7–1 and B7–2 into human multiple myeloma cells by recombinant adeno-associated virus enhances the cytolytic T cell response

C-M Wendtner
A Nolte
M Hallek
Research01 Jul 1997
Gene Therapy

Volume: 4, P: 726-735
Characterization of the chimeric retinoic acid receptor RARα/VDR

SM Pemrick
P Abarzúa
JF Grippo
Research08 May 1998
Leukemia

Volume: 12, P: 554-562
Effect of exogenous insulin on protein metabolism with differing nonprotein energy intakes in Type 2 diabetes mellitus

R Gougeon
EB Marliss
JA Morais
Research20 Apr 1998
International Journal of Obesity

Volume: 22, P: 250-261
ERdj5 protects goblet cells from endoplasmic reticulum stress-mediated apoptosis under inflammatory conditions

Hyunjin Jeong
Eun-Hye Hong
Hyun-Jeong Ko
ResearchOpen Access09 Feb 2023
Experimental & Molecular Medicine

Volume: 55, P: 401-412
The contribution of poly-L-lysine, epidermal growth factor and streptavidin to EGF/PLL/DNA polyplex formation

B Xu
S Wiehle
RJ Cristiano
Research03 Sept 1998
Gene Therapy

Volume: 5, P: 1235-1243
Effectiveness of HB2 (anti-CD7) – saporin immunotoxin in an in vivo model of human T-cell leukaemia developed in severe combined immunodeficient mice

BJ Morland
J Barley
DJ Flavell
Research01 Feb 1994
British Journal of Cancer

Volume: 69, P: 279-285
Inhibition of NF-κB prevents high glucose-induced proliferation and plasminogen activator inhibitor-1 expression in vascular smooth muscle cells

In-Kyung Jeong
Da Hee Oh
Hyung-Joon Yoo
ResearchOpen Access06 Oct 2011
Experimental & Molecular Medicine

Volume: 43, P: 684-692
Metabolic engineering as therapy for inborn errors of metabolism – development of mice with phenylalanine hydroxylase expression in muscle

CO Harding
K Wild
JA Wolff
Research21 May 1998
Gene Therapy

Volume: 5, P: 677-683
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Munib Mesinovic
Xin Ci Wong
David Zucman
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-43
Resting leptin responses to acute and chronic resistance training in type 2 diabetic men and women

JA Kanaley
LM Fenicchia
JL Azevedo Jr
Research23 Oct 2001
International Journal of Obesity

Volume: 25, P: 1474-1480
Unusual growth characteristics of human melanoma xenografts in the nude mouse: a model for desmoplasia, dormancy and progression

MFRM Gartner
C Fearns
EB Dowdle
Research01 Apr 1992
British Journal of Cancer

Volume: 65, P: 487-490
Lack of ‘tissue’ transglutaminase protein cross-linking leads to leakage of macromolecules from dying cells: relationship to development of autoimmunity in MRLlpr/lpr mice

Lucia Piredda
Alessandra Amendola
Laszlo Fesus
Research01 Aug 1997
Cell Death & Differentiation

Volume: 4, P: 463-472
hTERT promoter induces tumor-specific Bax gene expression and cell killing in syngenic mouse tumor model and prevents systemic toxicity

J Gu
M Andreeff
B Fang
Research11 Feb 2002
Gene Therapy

Volume: 9, P: 30-37
Topotecan–filgrastim combination is an effective regimen for mobilizing peripheral blood stem cells

E-J A Yeoh
JM Cunningham
AJ Gajjar
Research12 Oct 2001
Bone Marrow Transplantation

Volume: 28, P: 563-571
Renal kallikrein excretion: role of ethnicity, gender, environment, and genetic risk of hypertension

CK Song
JA Martinez
DT O’Connor
Research10 Jul 2000
Journal of Human Hypertension

Volume: 14, P: 461-468
Retinoid-induced apoptosis in normal and neoplastic tissues

Laszlo Nagy
Vilmos A Thomazy
Peter JA Davies
Reviews28 Jan 1998
Cell Death & Differentiation

Volume: 5, P: 11-19
2'-deoxy-5-azacytidine increases binding of cisplatin to DNA by a mechanism independent of DNA hypomethylation

JA Ellerhorst
P Frost
Y Chernajovsky
Research01 Feb 1993
British Journal of Cancer

Volume: 67, P: 209-215
Tumor-suppressive effects by adenovirus-mediated mda-7 gene transfer in non-small cell lung cancer cell in vitro

T Saeki
A Mhashilkar
R Ramesh
Research04 Dec 2000
Gene Therapy

Volume: 7, P: 2051-2057
Frequent CpG island methylation in precursor lesions and early gastric adenocarcinomas

Jae-Hyuk Lee
Seun-Ja Park
Tsung-Teh Wu
Research05 Apr 2004
Oncogene

Volume: 23, P: 4646-4654
The p90 ribosomal S6 kinase 2 specifically affects mitotic progression by regulating the basal level, distribution and stability of mitotic spindles

Yun Yeon Park
Hyun-Ja Nam
Jae-Ho Lee
ResearchOpen Access05 Aug 2016
Experimental & Molecular Medicine

Volume: 48, P: e250
Do level and variability of systolic blood pressure predict arterial properties or vice versa?

Y-P Liu
Y-M Gu
J A Staessen
Research24 Oct 2013
Journal of Human Hypertension

Volume: 28, P: 316-322
Serine/threonine phosphorylation in cytokine signal transduction

JA McCubrey
W Stratford May
A Mufson
Reviews06 Jan 2000
Leukemia

Volume: 14, P: 9-21
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Ali Abbas
Sheryl Ann Abdukahil
Luis Felipe Reyes
ResearchOpen Access30 Jul 2022
Scientific Data

Volume: 9, P: 1-22
An effective immunization and cancer treatment with activated dendritic cells transduced with full-length wild-type p53

EY Nikitina
S Chada
DI Gabrilovich
Research25 Mar 2002
Gene Therapy

Volume: 9, P: 345-352
Genetic Alterations in Gastric Adenomas of Intestinal and Foveolar Phenotypes

Susan C Abraham
Seun Ja Park
Tsung-Teh Wu
Research01 Aug 2003
Modern Pathology

Volume: 16, P: 786-795

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