Nature Search

Analysis of CD34 populations in mobilised peripheral blood stem cell harvests and in bone marrow by fluorescent in situ hybridisation for the bcr/abl gene fusion in patients with chronic granulocytic leukaemia

JAE Irving
A Lennard
AM Dickinson
Research12 Jun 1999
Leukemia

Volume: 13, P: 944-949
Molecular remission in Philadelphia-positive adult acute lymphoblastic leukaemia rapidly induced by conventional-dose chemotherapy

JAE Irving
R Finney
SJ Proctor
Research05 Mar 1998
Bone Marrow Transplantation

Volume: 21, P: 323-325
The power of genetic diversity in genome-wide association studies of lipids

A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.

Sarah E. Graham
Shoa L. Clarke
Cristen J. Willer
Research09 Dec 2021
Nature

Volume: 600, P: 675-679
Rethinking gastric cancer prevention through an immigrant health lens

Gastric cancer is often overlooked in the United States, yet East Asian and other immigrant communities face a markedly increased burden. A community-based, migration-informed approach is needed to strengthen prevention and reduce disparities.

Chul S. Hyun
Sarah Soyeon Oh
Jae Il Shin
Comments & Opinion21 Jul 2025
Nature Reviews Gastroenterology & Hepatology

Volume: 22, P: 600-601
CD4⁺ T cells display a spectrum of recall dynamics during re-infection with malaria parasites

CD4⁺ T cells are known to be important in Plasmodium infection. Here the authors use mouse models to track antigen-experienced TCR transgenic and polyclonal CD4⁺ T cells during Plasmodium re-infection, and show different T cell phenotypes and varied responses in different areas of the spleen.

Hyun Jae Lee
Marcela L. Moreira
Ashraful Haque
ResearchOpen Access28 Jun 2024
Nature Communications

Volume: 15, P: 1-18
ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma

In two cohorts of patients with glioblastoma who received anti-PD-1, Sonabend and colleagues show that ERK1/2 phosphorylation, detected by immunohistochemistry, provides a biomarker for MAPK/ERK pathway activity and better survival on this therapy.

Víctor A. Arrieta
Andrew X. Chen
Adam M. Sonabend
Research29 Nov 2021
Nature Cancer

Volume: 2, P: 1372-1386
Comparative neurofilament light chain trajectories in CSF and plasma in autosomal dominant Alzheimer’s disease

This study supports neurofilament light chain protein (NfL) in both cerebrospinal fluid (CSF) and blood as an early marker of neurodegeneration in Alzheimer’s disease but suggests that NfL in CSF may be better suited than blood for monitoring clinical trial outcomes in symptomatic patients.

Anna Hofmann
Lisa M. Häsler
Jinbin Xu
ResearchOpen Access18 Nov 2024
Nature Communications

Volume: 15, P: 1-10
Longitudinal analysis of a dominantly inherited Alzheimer disease mutation carrier protected from dementia

A rare case of asymptomatic dominantly inherited Alzheimer’s reveals confined tau pathology and unique proteomic features, highlighting potential resilience mechanisms decades beyond expected onset.

Jorge J. Llibre-Guerra
M. Victoria Fernandez
Ellen Ziegemeier
Research10 Feb 2025
Nature Medicine

Volume: 31, P: 1267-1275
Endochondral ossification is required for haematopoietic stem-cell niche formation

This paper describes an in vivo assay of haematopoietic stem cell (HSC) niche formation. A population of progenitor cells is sorted from fetal bones, and when transplanted under the adult mouse kidney capsule, the cells recruit host-derived blood vessels, produce donor-derived ectopic bones, and generate a marrow cavity populated by host-derived long-term reconstituting haematopoeitic stem cells.

Charles K. F. Chan
Ching-Cheng Chen
Irving L. Weissman
Research10 Dec 2008
Nature

Volume: 457, P: 490-494
Artificial metalloenzymes

Artificial metalloenzymes harness metal cofactors that are not naturally found in enzymes and embed these in specifically selected or designed protein scaffolds. In this Primer, Vornholt et al. describe the best practices for designing and engineering artificial metalloenzymes.

Tobias Vornholt
Florian Leiss-Maier
Thomas R. Ward
Reviews01 Nov 2024
Nature Reviews Methods Primers

Volume: 4, P: 1-17
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Promotion of DNA end resection by BRCA1–BARD1 in homologous recombination

Using highly purified protein factors, we provide evidence that BRCA1–BARD1 physically interacts with EXO1, BLM and WRN and upregulates the activity of all three resection pathways.

Sameer Salunkhe
James M. Daley
Patrick Sung
Research11 Sept 2024
Nature

Volume: 634, P: 482-491
Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma

Group 3 medulloblastoma is an aggressive pediatric brain tumour that disseminates through the leptomeningeal cerebral spinal fluid. Here, the authors show that in Group 3 medulloblastoma NOTCH1 activates BMI1 through the activation of TWIST1, driving metastasis and self-renewal, and in mouse models a NOTCH1 blocking antibody decreased spinal metastases.

Suzana A. Kahn
Xin Wang
Samuel H. Cheshier
ResearchOpen Access08 Oct 2018
Nature Communications

Volume: 9, P: 1-9
Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma

Circular extrachromosomal DNA in high-risk medulloblastoma contributes to tumor heterogeneity and associates with relapse and survival. Enhancer rewiring events involving known oncogenes are frequent events, affecting transcription and proliferation.

Owen S. Chapman
Jens Luebeck
Lukas Chavez
ResearchOpen Access09 Nov 2023
Nature Genetics

Volume: 55, P: 2189-2199
Meta-analysis of neural systems underlying placebo analgesia from individual participant fMRI data

The neural mechanisms of placebo analgesia are not fully understood. Here the authors conducted a large scale meta-analysis of individual data from fMRI studies of pain and placebo conditions.

Matthias Zunhammer
Tamás Spisák
Fadel Zeidan
ResearchOpen Access02 Mar 2021
Nature Communications

Volume: 12, P: 1-11
Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer’s disease

Proteomic analysis of cerebrospinal fluid from individuals with autosomal dominant Alzheimer’s disease reveals how this complex and chronic disease evolves over many decades.

Erik C. B. Johnson
Shijia Bian
John Ringman
ResearchOpen Access07 Aug 2023
Nature Medicine

Volume: 29, P: 1979-1988
Publisher Correction: Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma

Suzana A. Kahn
Xin Wang
Samuel H. Cheshier
Amendments and CorrectionsOpen Access02 Nov 2018
Nature Communications

Volume: 9, P: 1
Author Correction: The power of genetic diversity in genome-wide association studies of lipids

Sarah E. Graham
Shoa L. Clarke
Cristen J. Willer
Amendments and Corrections26 May 2023
Nature

Volume: 618, P: E19-E20
Publisher Correction: ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma

Víctor A. Arrieta
Andrew X. Chen
Adam M. Sonabend
Amendments and Corrections11 Feb 2022
Nature Cancer

Volume: 3, P: 373
Niche-based screening identifies small-molecule inhibitors of leukemia stem cells

High-throughput screening systems that better mimic the physiological complexity of diseased tissues may aid the discovery of more efficacious compounds. A co-culture system that mimics the microenvironment of leukemia stem cells (LSCs) in bone marrow enables the discovery of compounds, including lovastatin, that selectively kill LSCs.

Kimberly A Hartwell
Peter G Miller
Todd R Golub
Research27 Oct 2013
Nature Chemical Biology

Volume: 9, P: 840-848
Positron emission tomography and magnetic resonance imaging methods and datasets within the Dominantly Inherited Alzheimer Network (DIAN)

The Dominantly Inherited Alzheimer Network neuroimaging repository is a free resource consisting of PET and MRI scans from 533 individuals across 206 families who are deeply phenotyped with genetic, clinical, cognitive and biofluid sampling.

Nicole S. McKay
Brian A. Gordon
Christian la Fougère
ResearchOpen Access10 Jul 2023
Nature Neuroscience

Volume: 26, P: 1449-1460
CD8⁺ T cells regulate tumour ferroptosis during cancer immunotherapy

Interferon-γ induces ferroptotic cell death in tumours by suppressing cystine uptake and promoting lipid peroxidation.

Weimin Wang
Michael Green
Weiping Zou
Research01 May 2019
Nature

Volume: 569, P: 270-274
Myeloid cell-specific sirtuin 6 deficiency delays wound healing in mice by modulating inflammation and macrophage phenotypes

Jeung-Hyun Koo
Hyun-Young Jang
Byung-Hyun Park
ResearchOpen Access26 Apr 2019
Experimental & Molecular Medicine

Volume: 51, P: 1-10
Genome-wide methylation analysis identifies ELOVL5 as an epigenetic biomarker for the risk of type 2 diabetes mellitus

Joo-Yeon Hwang
Hyo Jung Lee
Bong-Jo Kim
ResearchOpen Access05 Oct 2018
Scientific Reports

Volume: 8, P: 1-8
Finding Long-COVID: temporal topic modeling of electronic health records from the N3C and RECOVER programs

Shawn T. O’Neil
Charisse Madlock-Brown
Melissa A. Haendel
ResearchOpen Access21 Oct 2024
npj Digital Medicine

Volume: 7, P: 1-13
Relationships between structural stigma, societal stigma, and minority stress among gender minority people

Kristen D. Clark
Mitchell R. Lunn
Annesa Flentje
ResearchOpen Access23 Jan 2025
Scientific Reports

Volume: 15, P: 1-15
Novel target for induction of apoptosis by cyclo-oxygenase-2 inhibitor SC-236 through a protein kinase C-β₁-dependent pathway

Xiao-Hua Jiang
Shiu-Kum Lam
Benjamin Chun-Yu Wong
Research05 Sept 2002
Oncogene

Volume: 21, P: 6113-6122
PKC-η mediates glioblastoma cell proliferation through the Akt and mTOR signaling pathways

Sean E Aeder
Patrick M Martin
Isa M Hussaini
Research18 Oct 2004
Oncogene

Volume: 23, P: 9062-9069
The United States COVID-19 Forecast Hub dataset

Estee Y. Cramer
Yuxin Huang
Nicholas G. Reich
ResearchOpen Access01 Aug 2022
Scientific Data

Volume: 9, P: 1-15
Comparative effects of overexpression of p27^Kip1 and p21^Cip1/Waf1 on growth and differentiation in human colon carcinoma cells

Hirofumi Yamamoto
Jae-Won Soh
I Bernard Weinstein
Research19 Jan 1999
Oncogene

Volume: 18, P: 103-115

Search

Analysis of CD34 populations in mobilised peripheral blood stem cell harvests and in bone marrow by fluorescent in situ hybridisation for the bcr/abl gene fusion in patients with chronic granulocytic leukaemia

Molecular remission in Philadelphia-positive adult acute lymphoblastic leukaemia rapidly induced by conventional-dose chemotherapy

The power of genetic diversity in genome-wide association studies of lipids

Rethinking gastric cancer prevention through an immigrant health lens

CD4⁺ T cells display a spectrum of recall dynamics during re-infection with malaria parasites

ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma

Comparative neurofilament light chain trajectories in CSF and plasma in autosomal dominant Alzheimer’s disease

Longitudinal analysis of a dominantly inherited Alzheimer disease mutation carrier protected from dementia

Endochondral ossification is required for haematopoietic stem-cell niche formation

Artificial metalloenzymes

Mapping the human genetic architecture of COVID-19

Promotion of DNA end resection by BRCA1–BARD1 in homologous recombination

Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma

Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma

Meta-analysis of neural systems underlying placebo analgesia from individual participant fMRI data

Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer’s disease

Publisher Correction: Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma

Author Correction: The power of genetic diversity in genome-wide association studies of lipids

Publisher Correction: ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma

Niche-based screening identifies small-molecule inhibitors of leukemia stem cells

Positron emission tomography and magnetic resonance imaging methods and datasets within the Dominantly Inherited Alzheimer Network (DIAN)

CD8⁺ T cells regulate tumour ferroptosis during cancer immunotherapy

Myeloid cell-specific sirtuin 6 deficiency delays wound healing in mice by modulating inflammation and macrophage phenotypes

Genome-wide methylation analysis identifies ELOVL5 as an epigenetic biomarker for the risk of type 2 diabetes mellitus

Finding Long-COVID: temporal topic modeling of electronic health records from the N3C and RECOVER programs

Relationships between structural stigma, societal stigma, and minority stress among gender minority people

Novel target for induction of apoptosis by cyclo-oxygenase-2 inhibitor SC-236 through a protein kinase C-β₁-dependent pathway

PKC-η mediates glioblastoma cell proliferation through the Akt and mTOR signaling pathways

The United States COVID-19 Forecast Hub dataset

Comparative effects of overexpression of p27^Kip1 and p21^Cip1/Waf1 on growth and differentiation in human colon carcinoma cells

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