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Showing 151–200 of 207 results

Advanced filters: Author: JOHN ECCLES Clear advanced filters

A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor–negative breast cancer

Christopher Haiman and colleagues report a genome-wide association study for estrogen receptor (ER)-negative breast cancer in women of African and European ancestry. They identify a variant at the TERT-CLPTM1L locus on 5p15 as associated with ER-negative and triple-negative breast cancer. This locus also harbors multiple variants associated with a range of other cancers.

Christopher A Haiman
Gary K Chen
Fergus J Couch
Research30 Oct 2011
Nature Genetics

Volume: 43, P: 1210-1214
CDX2 mutations do not account for juvenile polyposis or Peutz–Jeghers syndrome and occur infrequently in sporadic colorectal cancers

K L Woodford-Richens
S Halford
I P M Tomlinson
ResearchOpen Access15 May 2001
British Journal of Cancer

Volume: 84, P: 1314-1316
Which BPH treatment is the most clinically efficacious and cost-effective?

John Fitzpatrick
Comments & Opinion15 May 2007
Nature Clinical Practice Urology

Volume: 4, P: 358-359
Expertise in research integration and implementation for tackling complex problems: when is it needed, where can it be found and how can it be strengthened?

Gabriele Bammer
Michael O’Rourke
George P. Richardson
ResearchOpen Access13 Jan 2020
Palgrave Communications

Volume: 6, P: 1-16
The Western Diet Regulates Hippocampal Microvascular Gene Expression: An Integrated Genomic Analyses in Female Mice

Saivageethi Nuthikattu
Dragan Milenkovic
Amparo Villablanca
ResearchOpen Access13 Dec 2019
Scientific Reports

Volume: 9, P: 1-19
Host factors are associated with vaginal microbiome structure in pregnancy in the ECHO Cohort Consortium

Kimberly McKee
Christine M. Bassis
Lynne M. Smith
ResearchOpen Access23 May 2024
Scientific Reports

Volume: 14, P: 1-19
A human breast cancer-derived xenograft and organoid platform for drug discovery and precision oncology

Welm and colleagues present a biobank of human-derived xenografts and organoids and demonstrate its value for high-throughput drug screening and applied precision medicine.

Katrin P. Guillen
Maihi Fujita
Alana L. Welm
ResearchOpen Access24 Feb 2022
Nature Cancer

Volume: 3, P: 232-250
Prediction of antisense oligonucleotide efficacy by in vitro methods

Olga Matveeva
Brice Felden
Susan M. Freier
Special Features01 Dec 1998
Nature Biotechnology

Volume: 16, P: 1374-1375
Mendelian randomisation study of smoking exposure in relation to breast cancer risk

Hanla A. Park
Sonja Neumeyer
Jenny Chang-Claude
ResearchOpen Access02 Aug 2021
British Journal of Cancer

Volume: 125, P: 1135-1145
Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Edward J Saunders
Tokhir Dadaev
Zsofia Kote-Jarai
ResearchOpen Access10 Mar 2016
British Journal of Cancer

Volume: 114, P: 945-952
Germline HOXB13 mutations p.G84E and p.R217C do not confer an increased breast cancer risk

Jingjing Liu
Wendy J. C. Prager - van der Smissen
Antoinette Hollestelle
ResearchOpen Access16 Jun 2020
Scientific Reports

Volume: 10, P: 1-14
The International HapMap Project

Richard A. Gibbs
John W. Belmont
Toshihiro Tanaka
Special Features18 Dec 2003
Nature

Volume: 426, P: 789-796
Genome-wide association study of germline variants and breast cancer-specific mortality

Maria Escala-Garcia
Qi Guo
Marjanka K. Schmidt
ResearchOpen Access21 Feb 2019
British Journal of Cancer

Volume: 120, P: 647-657
E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium

Hisani N. Horne
Hannah Oh
Jonine D. Figueroa
ResearchOpen Access26 Apr 2018
Scientific Reports

Volume: 8, P: 1-11
Role of triglyceride-rich lipoproteins in diabetic nephropathy

A large body of evidence suggests that excess amounts of lipoproteins and lipids can induce glomerular injury and tubulointerstitial fibrosis, and may accelerate the progression of nephropathy in patients with diabetes. In this Review, John Rutledge and colleagues describe the influence of lipoproteins, specifically triglyceride-rich lipoproteins, on the development and perpetuation of diabetic nephropathy.

John C. Rutledge
Kit F. Ng
Dennis W. Wilson
Reviews04 May 2010
Nature Reviews Nephrology

Volume: 6, P: 361-370
Designing development programs for non-traditional antibacterial agents

Non-traditional antibacterial agents are challenging to develop. In this Perspective, the authors argue that the distinction between traditional and non-traditional agents has only limited relevance for regulatory purposes, although products with non-traditional goals focused on population-level benefits might benefit from extension of current paradigms.

John H. Rex
Holly Fernandez Lynch
Kevin Outterson
ReviewsOpen Access31 Jul 2019
Nature Communications

Volume: 10, P: 1-10
Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data

Alberto Romagnoni
Simon Jégou
Pamela Whittaker
ResearchOpen Access17 Jul 2019
Scientific Reports

Volume: 9, P: 1-18
Four consecutive yearly point-prevalence studies in Wales indicate lack of improvement in sepsis care on the wards

Maja Kopczynska
Harry Unwin
Judith E. Hall
ResearchOpen Access10 Aug 2021
Scientific Reports

Volume: 11, P: 1-12
Biomarker research in prostate cancer—towards utility, not futility

The pathogenesis and treatment of prostate cancer is complex and challenging, and the development of useful biomarkers for disease progression would be extremely valuable to clinicians and patients making treatment decisions. In this Review, the authors suggest a series of algorithms, making up a clinical 'roadmap' of prostate cancer pathogenesis and management. This device could help in identifying points in the prostate cancer timeline where biomarkers are most needed.

Sheng Fei Oon
Stephen R. Pennington
R. William G. Watson
Reviews11 Mar 2011
Nature Reviews Urology

Volume: 8, P: 131-138
COVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: a prospective observational cohort study

Kerstin Kläser
Erika Molteni
Emma L. Duncan
ResearchOpen Access28 Jun 2022
Scientific Reports

Volume: 12, P: 1-17
Genomic epidemiology of SARS-CoV-2 in a university outbreak setting and implications for public health planning

Sema Nickbakhsh
Joseph Hughes
Alison Smith-Palmer
ResearchOpen Access19 Jul 2022
Scientific Reports

Volume: 12, P: 1-17
Developmental roadmap for antimicrobial susceptibility testing systems

This Consensus Statement presents the barriers that currently prevent the timely development and implementation of novel and rapid antimicrobial susceptibility testing platforms, including the costs involved, uptake of new tools, legal and regulatory aspects, difficulties conducting clinical trials and quality control, and presents possible solutions.

Alex van Belkum
Till T. Bachmann
Wm. Michael Dunne Jr
ReviewsOpen Access17 Oct 2018
Nature Reviews Microbiology

Volume: 17, P: 51-62
Correction: Polygenic risk modeling for prediction of epithelial ovarian cancer risk

Eileen O. Dareng
Jonathan P. Tyrer
Paul D. P. Pharoah
Amendments and CorrectionsOpen Access22 Mar 2022
European Journal of Human Genetics

Volume: 30, P: 630-631
Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition

Christos Mikropoulos
Christina G Hutten Selkirk
Rosalind A Eeles
ResearchOpen Access04 Jan 2018
British Journal of Cancer

Volume: 118, P: 266-276
Alteration of barrier properties, stratum corneum ceramides and microbiome composition in response to lotion application on cosmetic dry skin

Barry Murphy
Sally Grimshaw
Andrew E. Mayes
ResearchOpen Access26 Mar 2022
Scientific Reports

Volume: 12, P: 1-11
A framework for the development of effective anti-metastatic agents

Most cancer-related deaths are attributable to metastasis, but few treatments are specifically designed to disrupt this process. In this Position Paper, representatives of the joint Cancer Research UK and Cancer Therapeutics CRC Australia Metastasis Working Group describe the challenges associated with discovering and developing anticancer agents designed specifically to prevent or delay the metastatic outgrowth of cancer and provide guidance on how these challenges might be overcome.

Robin L. Anderson
Theo Balasas
James W. A. Ritchie
ReviewsOpen Access04 Dec 2018
Nature Reviews Clinical Oncology

Volume: 16, P: 185-204
Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study

Suzanne C. Dixon-Suen
Christina M. Nagle
Penelope M. Webb
ResearchOpen Access20 Mar 2018
British Journal of Cancer

Volume: 118, P: 1123-1129
Risks of breast or ovarian cancer in BRCA1 or BRCA2 predictive test negatives: findings from the EMBRACE study

Fabio Girardi
Daniel R Barnes
Antonis C Antoniou
ResearchOpen Access22 Mar 2018
Genetics in Medicine

Volume: 20, P: 1575-1582
The predictive ability of the 313 variant–based polygenic risk score for contralateral breast cancer risk prediction in women of European ancestry with a heterozygous BRCA1 or BRCA2 pathogenic variant

Inge M. M. Lakeman
Alexandra J. van den Broek
Marjanka K. Schmidt
ResearchOpen Access10 Jun 2021
Genetics in Medicine

Volume: 23, P: 1726-1737
Dual function of thalamic low-vigilance state oscillations: rhythm-regulation and plasticity

During low-vigilance states, thalamic neurons exhibit diverse rhythmic activities that contribute to specific parts of the electroencephalogram rhythm. In this perspective, Crunelli and colleagues propose that thalamic oscillations of these low-vigilance states also have a plasticity function that modifies the strength of excitatory and inhibitory synapses in local neuronal assemblies.

Vincenzo Crunelli
Magor L. Lőrincz
Adam C. Errington
Reviews11 Jan 2018
Nature Reviews Neuroscience

Volume: 19, P: 107-118
Phencyclidine-induced Loss of Asymmetric Spine Synapses in Rodent Prefrontal Cortex is Reversed by Acute and Chronic Treatment with Olanzapine

John D Elsworth
Bret A Morrow
Robert H Roth
Research15 Jun 2011
Neuropsychopharmacology

Volume: 36, P: 2054-2061
Cellular geometry and epithelial-mesenchymal plasticity intersect with PIEZO1 in breast cancer cells

A multidisciplinary approach suggests the importance of cellular geometry in modulating calcium signals in breast cancer cells via the PIEZO1 force sensing channel which is also associated with breast cancer cell plasticity.

Choon Leng So
Mélanie Robitaille
Gregory R. Monteith
ResearchOpen Access17 Apr 2024
Communications Biology

Volume: 7, P: 1-14
Multiple reward signals in the brain

Wolfram Schultz
Reviews01 Dec 2000
Nature Reviews Neuroscience

Volume: 1, P: 199-207
The molecular organization of cerebellar long-term depression

Masao Ito
Reviews01 Nov 2002
Nature Reviews Neuroscience

Volume: 3, P: 896-902
The protein and miRNA profile of plasma extracellular vesicles (EVs) can distinguish feline mammary adenocarcinoma patients from healthy feline controls

Jane Howard
John Browne
Pamela Kelly
ResearchOpen Access06 Jun 2023
Scientific Reports

Volume: 13, P: 1-15
Dendritic integration: 60 years of progress

Neurons receive synaptic input primarily onto their dendrites. This review focuses on how synaptic inputs are integrated by dendrites, with an emphasis on recent work in the intact brain. It describes the range of computations dendrites perform on their inputs, highlighting their critical role in information processing in the brain.

Greg J Stuart
Nelson Spruston
Reviews25 Nov 2015
Nature Neuroscience

Volume: 18, P: 1713-1721
The paucity of morality in everyday talk

Mohammad Atari
Matthias R. Mehl
Morteza Dehghani
ResearchOpen Access12 Apr 2023
Scientific Reports

Volume: 13, P: 1-12
Simulating toxicokinetic variability to identify susceptible and highly exposed populations

Miyuki Breen
John F. Wambaugh
Caroline L. Ring
Research03 Nov 2022
Journal of Exposure Science & Environmental Epidemiology

Volume: 32, P: 855-863
Activation of M1 cholinergic receptors in mouse somatosensory cortex enhances information processing and detection behaviour

A combination of pharmacological modulation with in vivo electrophysiology, 2-photon calcium imaging and behavioural analysis characterises the role of cholinergic M1 receptors in sensory information processing and perception.

Wricha Mishra
Ehsan Kheradpezhouh
Ehsan Arabzadeh
ResearchOpen Access02 Jan 2024
Communications Biology

Volume: 7, P: 1-14
Synaptic plasticity at hippocampal mossy fibre synapses

Roger A. Nicoll
Dietmar Schmitz
Reviews01 Nov 2005
Nature Reviews Neuroscience

Volume: 6, P: 863-876
BORIS, a paralogue of the transcription factor, CTCF, is aberrantly expressed in breast tumours

V D'Arcy
N Pore
E Klenova
ResearchOpen Access15 Jan 2008
British Journal of Cancer

Volume: 98, P: 571-579
The Manchester International Consensus Group recommendations for the management of gynecological cancers in Lynch syndrome

Emma J. Crosbie
Neil A. J. Ryan
D. Gareth Evans
ResearchOpen Access28 Mar 2019
Genetics in Medicine

Volume: 21, P: 2390-2400
Functional Imaging of the Outer Retinal Complex using High Fidelity Imaging Retinal Densitometry

Tom H. Margrain
David Atkinson
Ashley Wood
ResearchOpen Access11 Mar 2020
Scientific Reports

Volume: 10, P: 1-11
Targeted pruning of a neuron’s dendritic tree via femtosecond laser dendrotomy

Mary Ann Go
Julian Min Chiang Choy
Vincent Ricardo Daria
ResearchOpen Access07 Jan 2016
Scientific Reports

Volume: 6, P: 1-9
Retinotopic effects of visual attention revealed by dichoptic multifocal pupillography

Yanti Rosli
Corinne Frances Carle
Ted Maddess
ResearchOpen Access14 Feb 2018
Scientific Reports

Volume: 8, P: 1-13
Integration of visual and whisker signals in rat superior colliculus

Saba Gharaei
Ehsan Arabzadeh
Samuel G. Solomon
ResearchOpen Access06 Nov 2018
Scientific Reports

Volume: 8, P: 1-16
Novel morphometric analysis of higher order structure of human radial peri-papillary capillaries: relevance to retinal perfusion efficiency and age

Marconi Barbosa
Ted Maddess
Tailoi Chan-Ling
ResearchOpen Access17 Sept 2019
Scientific Reports

Volume: 9, P: 1-16
Temporal dynamics of choice behavior in rats and humans: an examination of pre- and post-choice latencies

Justine Fam
Fred Westbrook
Ehsan Arabzadeh
ResearchOpen Access10 Feb 2016
Scientific Reports

Volume: 6, P: 1-12
Comparing multifocal pupillographic objective perimetry (mfPOP) and multifocal visual evoked potentials (mfVEP) in retinal diseases

Faran Sabeti
Andrew C. James
Ted Maddess
ResearchOpen Access03 Apr 2017
Scientific Reports

Volume: 7, P: 1-12
Response dynamics of rat barrel cortex neurons to repeated sensory stimulation

Ehsan Kheradpezhouh
Mehdi Adibi
Ehsan Arabzadeh
ResearchOpen Access13 Sept 2017
Scientific Reports

Volume: 7, P: 1-10

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