Gottesman and colleagues review the most common mechanism of resistance to anticancer drugs — drug efflux from cancer cells mediated by ATP-binding cassette (ABC) transporters — and discuss various approaches to combating multidrug resistant cancer, including the development of drugs that inhibit, engage, evade or exploit efflux by ABC transporters.
- Gergely Szakács
- Jill K. Paterson
- Michael M. Gottesman
