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Widespread 8-oxoguanine modifications of miRNA seeds differentially regulate redox-dependent cancer development

Eom, Peak, Park, Ahn and colleagues reveal and provide a comprehensive resource of 8-oxoguanine modifications in tumour microRNAs and show how they differentially influence malignancy progression in gliomas and hepatocellular carcinoma.

Sangkyeong Eom
Jongjin Peak
Sung Wook Chi
Research07 Sept 2023
Nature Cell Biology

Volume: 25, P: 1369-1383
Proteosomal degradation of NSD2 by BRCA1 promotes leukemia cell differentiation

Park et al. identify Multiple Myeloma SET domain (MMSET/NSD2) in a large-scale CRISPR screen of genes whose depletion regulates hematopoietic differentiation and found it to interact with BRCA1. Thus regulation of MMSET/NSD2 stability BRCA1-mediated ubiquitination could be explored for potential therapeutic interventions in multiple myeloma.

Jin Woo Park
Joo-Young Kang
Sang-Beom Seo
ResearchOpen Access21 Aug 2020
Communications Biology

Volume: 3, P: 1-12
8-Oxoguanine: from oxidative damage to epigenetic and epitranscriptional modification

Ja Young Hahm
Jongyeun Park
Sung Wook Chi
ReviewsOpen Access21 Oct 2022
Experimental & Molecular Medicine

Volume: 54, P: 1626-1642

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