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Showing 1–3 of 3 results
Advanced filters: Author: Jack Girton Clear advanced filters

  • Food-grade titanium dioxide (fgTiO2) is a biopersistent particle, but neither the target cells nor the risks of fgTiO2 are well understood. Here, the authors identify immunocompetent cell targets of fgTiO2 in humans, most notably in the subepithelial dome region of intestinal Peyer’s patches, and demonstrate a mouse model allowing human-relevant risk assessments of ingested, bio-persistent (nano)particles.

    • John W. Wills
    • Alicja Dabrowska
    • Jonathan J. Powell
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • The chromosomal kinase JIL-1 is responsible for interphase histone H3S10 phosphorylation and has been proposed to protect active chromatin from heterochromatinisation. Here, the authors show that JIL-1 is stabilized and anchored to active genes and telomeric transposons by JASPer, which binds to H3K36me3 nucleosomes via its PWWP domain.

    • Christian Albig
    • Chao Wang
    • Catherine Regnard
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17