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Showing 1–13 of 13 results
Advanced filters: Author: Jack Paget Clear advanced filters

  • An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

    • Erola Pairo-Castineira
    • Konrad Rawlik
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 617, P: 764-768

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • This Review summarizes the natural progression of pre-metastatic niche formation and evolution, highlighting recent advances and future hurdles.

    • Héctor Peinado
    • Haiying Zhang
    • David Lyden
    Reviews
    Nature Reviews Cancer
    Volume: 17, P: 302-317

  • Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

    • Athanasios Kousathanas
    • Erola Pairo-Castineira
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 607, P: 97-103

  • The identification of pathogenic mutations within prion-like domains (PrLDs) of the RNA-binding proteins hnRNPA2B1 and hnRNPA1 add to our understanding of how mutations in these proteins lead to degenerative disease, and highlight the potential importance of PrLDs in degenerative diseases of the nervous system, muscle and bone.

    • Hong Joo Kim
    • Nam Chul Kim
    • J. Paul Taylor
    Research
    Nature
    Volume: 495, P: 467-473

  • As lamellar materials, smectics exhibit both liquid and solid characteristics, making them difficult to model at the mesoscale. Paget et al. propose a complex tensor order parameter that reflects the smectic symmetries, capable of describing complex defects including dislocations and disclinations.

    • Jack Paget
    • Marco G. Mazza
    • Tyler N. Shendruk
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • Ian Blair and colleagues use genome-wide linkage analysis and whole exome sequencing to identify mutations in the CCNF gene in large cohorts of amyotrophic lateral sclerosis and frontotemporal dementia patients. In addition to validating the mutations in international cohorts, the authors also show that mutant CCNFgene product affects ubiquitination and protein degradation in cultured cells.

    • Kelly L. Williams
    • Simon Topp
    • Ian P. Blair
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-8

  • Nanoplasmonic structures that can detect trace analytes via surface-enhanced Raman spectroscopy typically require sophisticated nanofabrication techniques. Self-assembly of gold nanoparticles into close-packed arrays at liquid/liquid and liquid/air interfaces is now used for the detection of multi-analytes from aqueous, organic or air phases.

    • Michael P. Cecchini
    • Vladimir A. Turek
    • Joshua B. Edel
    Research
    Nature Materials
    Volume: 12, P: 165-171

  • Vaccination is effective in protecting from COVID-19. Here the authors report immune responses and breakthrough infections in twice-vaccinated patients receiving anti-TNF treatments for inflammatory bowel disease, and find dampened vaccine responses that implicate the need of adapted vaccination schedules for these patients.

    • Simeng Lin
    • Nicholas A. Kennedy
    • Jeannie Bishop
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • In this Case History, Lacey and colleagues chronicle the events that led to an increased understanding of osteoclast biology, beginning with the identification of the pathway mediated by osteoprotegerin (OPG), receptor activator of NF-κB ligand (RANKL) and RANK. They discuss the strategies that were followed to target this pathway, culminating in the development of the RANKL-specific antibody denosumab, which is now approved for the treatment of osteoporosis and the prevention of cancer-related skeletal events.

    • David L. Lacey
    • William J. Boyle
    • Roger Dansey
    Reviews
    Nature Reviews Drug Discovery
    Volume: 11, P: 401-419