Hooking proteins to SUMO moieties is known to regulate key functions in the cell’s nucleus. This paper shows, for the first time, that SUMO controls the turnover of a neurotransmitter receptor — the kainate receptor: this work suggests that SUMO may target numerous other proteins working at junctions between nerve cells, thus probably contributing to key brain functions.
- Stéphane Martin
- Atsushi Nishimune
- Jeremy M. Henley