Genome-scale DNA methylation profiles have been generated at nucleotide resolution in mammalian cells using a combination of high-throughput bisulphite sequencing and single molecule-based sequencing. The DNA methylation maps cover the vast majority of CpG islands, as well as several other genomic regions, in murine embryonic stem cells, cells derived from ES cells and various primary cells.
- Alexander Meissner
- Tarjei S. Mikkelsen
- Eric S. Lander
