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Cancer-associated fibroblasts shape the formation of budding cancer cells at the invasive front of human colorectal cancer

Single-cell spatial transcriptomics reveals that CAFs at the invasive front of colorectal tumors induce pro-invasive changes in budding cancer cells, characterized by an 11-gene signature linked to metastasis and poor prognosis.

Juan L. García-Rodríguez
Ulrik Korsgaard
Lasse S. Kristensen
ResearchOpen Access16 Sept 2025
Communications Biology

Volume: 8, P: 1-16
Aligning computational pathology with clinical practice for colorectal cancer

Elias Baumann
José F. Carreño-Martínez
Inti Zlobec
ReviewsOpen Access27 Nov 2025
npj Precision Oncology

Volume: 9, P: 1-17

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Cancer-associated fibroblasts shape the formation of budding cancer cells at the invasive front of human colorectal cancer

Aligning computational pathology with clinical practice for colorectal cancer

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