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Showing 1–7 of 7 results
Advanced filters: Author: Jacob Notbohm Clear advanced filters

  • When studying nematic ordering of cells in a monolayer, it is commonly assumed that the principal stress and cell shape axes are tightly coupled. Here, the authors measure cell shape and cell-generated contractile stresses and show that cells in monolayers form correlated, dynamic domains in which the stresses are systematically misaligned with the cell bodies.

    • Mehrana R. Nejad
    • Liam J. Ruske
    • Julia M. Yeomans
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-8

  • Cells change shape and volume when they divide — not a simple task, especially when they are confined by surrounding tissue. Experiments now reveal that hydrostatic pressure changes generate the pushing forces that cells need to create space for division.

    • Jacob Notbohm
    • Brian Burkel
    News & Views
    Nature Physics
    Volume: 14, P: 533-534

  • Cell shape provides a structural signature for the classification and investigation of the jamming of bronchial epithelial layers in asthma.

    • Jin-Ah Park
    • Jae Hun Kim
    • Jeffrey J. Fredberg
    Research
    Nature Materials
    Volume: 14, P: 1040-1048

  • This paper describes mini-XPerT, a multiplexed screen to simultaneously measure cellular contraction, endothelial barrier function, and cytoskeletal and cell-cell junctional changes. It is the unique combination of these measurements that has enabled the authors to unveil the distinct biophysical mechanisms of barrier defense conferred by Y-27632 and Angpt-1. Mini-XPerT is likely to be applicable across the spectrum of basic and translational science - in mechanistic studies of the endothelium across numerous diseases, and for high-throughput drug discovery.

    • Ramin Rokhzan
    • Chandra C. Ghosh
    • Ramaswamy Krishnan
    Research
    Laboratory Investigation
    Volume: 99, P: 138-145