Nature Search

Best practices and tools in R and Python for statistical processing and visualization of lipidomics and metabolomics data

Mass spectrometry-based lipidomics and metabolomics generate large, complex datasets requiring effective analysis. Here, authors review key statistical and visualization methods alongside widely used R and Python tools, and provide a GitBook with step-by-step code for accessible, reproducible data analysis.

Jakub Idkowiak
Jonas Dehairs
Michal Holčapek
ReviewsOpen Access30 Sept 2025
Nature Communications

Volume: 16, P: 1-19
Anemia prevalence in women of reproductive age in low- and middle-income countries between 2000 and 2018

Geospatial estimates of the prevalence of anemia in women of reproductive age across 82 low-income and middle-income countries reveals considerable heterogeneity and inequality at national and subnational levels, with few countries on track to meet the WHO Global Nutrition Targets by 2030.

Damaris Kinyoki
Aaron E. Osgood-Zimmerman
Simon I. Hay
ResearchOpen Access12 Oct 2021
Nature Medicine

Volume: 27, P: 1761-1782
Tough and stretchable ionogels by in situ phase separation

Two monomers with distinct solubility of their corresponding polymers in an ionic liquid enable tuning of the microstructure of the copolymers during their polymerization. Thus, energy dissipative and elastic molecular domains are created, resulting in highly tough and stretchable ionogels.

Meixiang Wang
Pengyao Zhang
Michael D. Dickey
Research21 Feb 2022
Nature Materials

Volume: 21, P: 359-365
Inflammatory disease progression shapes nanoparticle biomolecular corona-mediated immune activation profiles

Nanoparticle biomolecular corona fingerprints vary with disease state. Here, the authors use integrated multi-omics to show that inflammatory disease dynamics alter corona formation, immune cell interactions, and activation profiles via TLR4 signalling, which could impact nanoparticle uses.

Jacob R. Shaw
Nicholas Caprio
Ryan M. Pearson
ResearchOpen Access22 Jan 2025
Nature Communications

Volume: 16, P: 1-14
Single cell atlas identifies lipid-processing and immunomodulatory endothelial cells in healthy and malignant breast

Tumor blood vessels contribute to cancer growth, invasion and metastasis. Here, by using single cell transcriptomics, the authors report an inventory of endothelial cell heterogeneity in patients with breast cancer, including a subtype that expresses genes involved in lipid processing and is regulated by PPAR-γ.

Vincent Geldhof
Laura P. M. H. de Rooij
Peter Carmeliet
ResearchOpen Access20 Sept 2022
Nature Communications

Volume: 13, P: 1-19
Physiogenomic resources for rat models of heart, lung and blood disorders

Renae L Malek
Hong-ying Wang
Norman H Lee
Research15 Jan 2006
Nature Genetics

Volume: 38, P: 234-239
Identification of HIV transmitting CD11c⁺ human epidermal dendritic cells

Composition and function of immune populations at barrier surfaces is crucial for response to infection. Here, the authors identify a population of dendritic cells in human epidermis, abundant in anogenital epithelia and distinct from Langerhans cells by surface phenotype and by high capacity for HIV infection and transmission.

Kirstie M. Bertram
Rachel A. Botting
Andrew N. Harman
ResearchOpen Access21 Jun 2019
Nature Communications

Volume: 10, P: 1-15
The overlapping burden of the three leading causes of disability and death in sub-Saharan African children

In this disease mapping study, the authors estimate disability-adjusted life year rates for three of the major causes of mortality for children under five 43 countries in sub-Saharan Africa. They identify significant heterogeneity at the subnational level, highlighting the need for a targeted intervention approach.

Robert C. Reiner Jr.
Catherine A. Welgan
Simon I. Hay
ResearchOpen Access06 Dec 2022
Nature Communications

Volume: 13, P: 1-14
Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants

A multi-ancestry genome-wide association study of prostate cancer performed in 156,319 cases and 788,443 controls identifies 187 novel risk variants associated with the disease. Genetic risk scores associated with overall risk, and risk of aggressive disease in men of African ancestry.

Anqi Wang
Jiayi Shen
Christopher A. Haiman
Research09 Nov 2023
Nature Genetics

Volume: 55, P: 2065-2074
Establishing community reference samples, data and call sets for benchmarking cancer mutation detection using whole-genome sequencing

Tumor–normal paired DNA samples from a breast cancer cell line and a matched lymphoblastoid cell line enable calibration of clinical sequencing pipelines and benchmarking ‘tumor-only’ or ‘matched tumor–normal’ analyses.

Li Tai Fang
Bin Zhu
Yuanting Zheng
Research09 Sept 2021
Nature Biotechnology

Volume: 39, P: 1151-1160
Toward best practice in cancer mutation detection with whole-genome and whole-exome sequencing

Recommendations are given on optimal read coverage and selection of calling algorithm to maximize the reproducibility of cancer mutation detection in whole-genome or whole-exome sequencing.

Wenming Xiao
Luyao Ren
Leming Shi
Research09 Sept 2021
Nature Biotechnology

Volume: 39, P: 1141-1150
Clinical evaluation of AI-assisted muscle ultrasound for monitoring muscle wasting in ICU patients

Phung Tran Huy Nhat
Nguyen Van Hao
Alberto Gomez
ResearchOpen Access26 Jun 2024
Scientific Reports

Volume: 14, P: 1-9
Discovery of 42 genome-wide significant loci associated with dyslexia

Genome-wide analysis of self-reported dyslexia identifies 42 associated loci, including 27 not previously associated with cognitive traits. Dyslexia shows genetic correlation with ambidexterity but not neuroanatomical measures of language-related circuitry.

Catherine Doust
Pierre Fontanillas
Michelle Luciano
ResearchOpen Access20 Oct 2022
Nature Genetics

Volume: 54, P: 1621-1629
Global Impacts Dataset of Invasive Alien Species (GIDIAS)

Sven Bacher
Ellen Ryan-Colton
Tsungai A. Zengeya
ResearchOpen Access21 May 2025
Scientific Data

Volume: 12, P: 1-10
AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach
Denzil Bernard
Abraham Heifets
ResearchOpen Access02 Apr 2024
Scientific Reports

Volume: 14, P: 1-16
Intranasal vaccination with an NDV-vectored SARS-CoV-2 vaccine protects against Delta and Omicron challenges

Bryce M. Warner
Jacob G. E. Yates
Darwyn Kobasa
ResearchOpen Access23 May 2024
npj Vaccines

Volume: 9, P: 1-16
Computer-aided prognosis of tuberculous meningitis combining imaging and non-imaging data

Liane S. Canas
Trinh H. K. Dong
Marcus Schultz
ResearchOpen Access30 Jul 2024
Scientific Reports

Volume: 14, P: 1-13
Apolipoprotein E Isoform-specific changes related to stress and trauma exposure

Eileen Ruth S. Torres
Jenny Luo
Jacob Raber
ResearchOpen Access28 Mar 2022
Translational Psychiatry

Volume: 12, P: 1-11
A simultaneous [¹¹C]raclopride positron emission tomography and functional magnetic resonance imaging investigation of striatal dopamine binding in autism

Nicole R. Zürcher
Erin C. Walsh
Gabriel S. Dichter
ResearchOpen Access11 Jan 2021
Translational Psychiatry

Volume: 11, P: 1-11
Hypothesis-driven genome-wide association studies provide novel insights into genetics of reading disabilities

Kaitlyn M. Price
Karen G. Wigg
Cathy L. Barr
ResearchOpen Access29 Nov 2022
Translational Psychiatry

Volume: 12, P: 1-9
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Ali Abbas
Sheryl Ann Abdukahil
Luis Felipe Reyes
ResearchOpen Access30 Jul 2022
Scientific Data

Volume: 9, P: 1-22

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