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Showing 1–3 of 3 results
Advanced filters: Author: Jacqueline L Blankman Clear advanced filters

  • Scholsburg and colleagues show that prolonged inactivation of monoacylglycerol lipase, the principal degradative enzyme for the endocannabinoid 2-arachidonoylglycerol, antagonizes the brain endocannabinoid system. This is manifested as tolerance, impaired plasticity and receptor desensitization; these effects are similar to the effects of prolonged exposure to drugs of abuse.

    • Joel E Schlosburg
    • Jacqueline L Blankman
    • Benjamin F Cravatt
    Research
    Nature Neuroscience
    Volume: 13, P: 1113-1119

  • Marrs et al. show that the serine hydrolase α/β-hydrolase domain 6 (ABHD6) controls the accumulation and efficacy of the endocannabinoid 2-arachidonoylglycerol at cannabinoid receptors. ABHD6 is located post-synaptically and its selective inhibition permits the induction of cannabinoid receptor–dependent long-term depression by otherwise subthreshold stimulations.

    • William R Marrs
    • Jacqueline L Blankman
    • Nephi Stella
    Research
    Nature Neuroscience
    Volume: 13, P: 951-957