By examining natural behavioral variation of an outbred strain of mice on a Pavlovian-to-instrumental transfer task, the authors show that the level of polysialylated neural cell adhesion molecule (PSA-NCAM) in the ventromedial prefrontal cortex (vmPFC) can predict the extinction and cue-induced reinstatement of alcohol seeking. The study also shows that depleting endogenous PSA-NCAM in the vmPFC in mice confers resistance to the extinction of alcohol seeking.
- Jacqueline M Barker
- Mary M Torregrossa
- Jane R Taylor
