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Showing 1–3 of 3 results
Advanced filters: Author: Jacqueline S. Jeruss Clear advanced filters

  • This Review discusses advances in implantable biomaterials that mimic the pre-metastatic niche and regulate the behaviour of tumour cells at the implant site, and their prospects for the detection of metastasis and for therapeutic interventions.

    • Brian A. Aguado
    • Grace G. Bushnell
    • Lonnie D. Shea
    Reviews
    Nature Biomedical Engineering
    Volume: 1, P: 1-12

  • 3D scaffolds can be used to recapitulate key aspects of the microenvironment of primary tumors and metastatic organs. Here the authors use subcutaneous porous 3D scaffold implants as a tool to study the immune signals in the lungs of metastatic breast cancer, revealing multifaceted roles of neutrophils in regulating lung metastasis.

    • Jing Wang
    • Ramon Ocadiz-Ruiz
    • Lonnie D. Shea
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-20

  • Tumour metastasis is a significant source of mortality, often because it is detected at an advanced stage. In this study, in an effort to identify metastasis at an early stage, Azarin et. al. capture and image metastasizing cells in mice in vivousing a biomaterial scaffold.

    • Samira M. Azarin
    • Ji Yi
    • Lonnie D Shea
    Research
    Nature Communications
    Volume: 6, P: 1-9