Nature Search

Specific depletion of immunoreactive growth hormone-releasing factor by monosodium glutamate in rat median eminence

B. Bloch
N. Ling
R. Guillemin
Research19 Jan 1984
Nature

Volume: 307, P: 272-273
An organism-wide atlas of hormonal signaling based on the mouse lemur single-cell transcriptome

Endocrinologists have traditionally focused on studying one hormone or organ system at a time. Here the authors use transcriptomic data from the mouse lemur to globally characterize primate hormonal signaling, describing hormone sources and targets, identifying conserved and primate specific regulation, and elucidating principles of the network.

Shixuan Liu
Camille Ezran
James E. Ferrell Jr.
ResearchOpen Access11 Mar 2024
Nature Communications

Volume: 15, P: 1-27
A molecular cell atlas of mouse lemur, an emerging model primate

Together with a companion paper, the generation of a transcriptomic atlas for the mouse lemur and analyses of example cell types establish this animal as a molecularly tractable primate model organism.

Antoine de Morree
Iwijn De Vlaminck
Mark A. Krasnow
ResearchOpen Access30 Jul 2025
Nature

Volume: 644, P: 173-184
Mouse lemur cell atlas informs primate genes, physiology and disease

Together with an accompanying paper presenting a transcriptomic atlas of the mouse lemur, interrogation of the atlas provides a rich body of data to support the use of the organism as a model for primate biology and health.

Camille Ezran
Shixuan Liu
Mark A. Krasnow
ResearchOpen Access30 Jul 2025
Nature

Volume: 644, P: 185-196
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Large genome-wide meta-analysis of clinically diagnosed late-onset Alzheimer’s disease (LOAD) from 94,437 individuals identifies new LOAD risk loci and implicates Aβ formation, tau protein binding, immune response and lipid metabolism.

Brian W. Kunkle
Benjamin Grenier-Boley
Margaret A. Pericak-Vance
Research28 Feb 2019
Nature Genetics

Volume: 51, P: 414-430
Functional Alteration of the Somatotrophic Axis in Transgenic Mice with Liver-Specific Expression of Human Insulin-like Growth Factor Binding Protein-1

Danielle Seurin
Pascal Froment
Michel Binoux
Research01 Aug 2002
Pediatric Research

Volume: 52, P: 168-174
New insights into the genetic etiology of Alzheimer’s disease and related dementias

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

Céline Bellenguez
Fahri Küçükali
Jean-Charles Lambert
ResearchOpen Access04 Apr 2022
Nature Genetics

Volume: 54, P: 412-436
Adversarial domain translation networks for integrating large-scale atlas-level single-cell datasets

An adversarial domain translation framework is presented for scalable integration of single-cell atlases across samples, technical platforms, data modalities and species.

Jia Zhao
Gefei Wang
Can Yang
Research30 May 2022
Nature Computational Science

Volume: 2, P: 317-330
Resveratrol does not mimic the positive effects of calorie restriction on lifespan in Microcebus murinus

Long-term resveratrol supplementation procures health benefits at middle-age in a non-human primate but does not mimic the positive effects of calorie restriction on lifespan and might even impair brain integrity at older ages.

Fabien Pifferi
Jérémy Terrien
Fabienne Aujard
ResearchOpen Access28 Feb 2025
Communications Biology

Volume: 8, P: 1-8
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Sven van der Lee, Julie Williams, Gerard Schellenberg and colleagues identify rare coding variants in PLCG2, ABI3 and TREM2 associated with Alzheimer's disease. These genes are highly expressed in microglia and provide additional evidence that the microglia-mediated immune response contributes to the development of Alzheimer's disease.

Rebecca Sims
Sven J van der Lee
Gerard D Schellenberg
Research17 Jul 2017
Nature Genetics

Volume: 49, P: 1373-1384
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

Julie Williams, Michael Owen and colleagues report staged follow-up and meta-analyses of genome-wide association studies for Alzheimer's disease from the GERAD+ consortium. They identify common variants at ABCA7 and MS4A6A/MS4A4E associated with Alzheimer's disease and support for several additional susceptibility loci.

Paul Hollingworth
Denise Harold
Julie Williams
Research03 Apr 2011
Nature Genetics

Volume: 43, P: 429-435
Roles of Hippocampal Somatostatin Receptor Subtypes in Stress Response and Emotionality

Thomas D Prévôt
François Gastambide
Jean-Louis Guillou
Research16 Dec 2016
Neuropsychopharmacology

Volume: 42, P: 1647-1656
Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Brian W. Kunkle
Benjamin Grenier-Boley
Margaret A. Pericak-Vance
Amendments and Corrections15 Aug 2019
Nature Genetics

Volume: 51, P: 1423-1424
Caloric restriction increases lifespan but affects brain integrity in grey mouse lemur primates

Fabien Pifferi et al. report survival and age-related brain atrophy data in grey mouse lemurs fed either a normal diet or a diet restricted in calories by 30%. They find that caloric restriction extended life span by 50% and decelerated brain white matter atrophy, but accelerated the loss of grey matter, in most of the cerebrum.

Fabien Pifferi
Jérémy Terrien
Fabienne Aujard
ResearchOpen Access05 Apr 2018
Communications Biology

Volume: 1, P: 1-8
Moderate decline in select synaptic markers in the prefrontal cortex (BA9) of patients with Alzheimer’s disease at various cognitive stages

Odile Poirel
Sébastien Mella
Salah El Mestikawy
ResearchOpen Access17 Jan 2018
Scientific Reports

Volume: 8, P: 1-14
A novel Alzheimer disease locus located near the gene encoding tau protein

G Jun
C A Ibrahim-Verbaas
L A Farrer
Research17 Mar 2015
Molecular Psychiatry

Volume: 21, P: 108-117
Promoting healthspan and lifespan with caloric restriction in primates

Fabien Pifferi et al. discuss the latest research in using caloric restriction for promoting healthspan and lifespan in primates. Their Comment touches on their previous study, addressing how to combine nutrition-based clinical protocols with interventions to delay the onset of age-related diseases.

Fabien Pifferi
Jérémy Terrien
Fabienne Aujard
Comments & OpinionOpen Access15 Mar 2019
Communications Biology

Volume: 2, P: 1-3
Parallel Loss of Hippocampal LTD and Cognitive Flexibility in a Genetic Model of Hyperdopaminergia

Elise Morice
Jean-Marie Billard
Marika Nosten-Bertrand
Research07 Mar 2007
Neuropsychopharmacology

Volume: 32, P: 2108-2116

Search

Specific depletion of immunoreactive growth hormone-releasing factor by monosodium glutamate in rat median eminence

An organism-wide atlas of hormonal signaling based on the mouse lemur single-cell transcriptome

A molecular cell atlas of mouse lemur, an emerging model primate

Mouse lemur cell atlas informs primate genes, physiology and disease

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Functional Alteration of the Somatotrophic Axis in Transgenic Mice with Liver-Specific Expression of Human Insulin-like Growth Factor Binding Protein-1

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Adversarial domain translation networks for integrating large-scale atlas-level single-cell datasets

Resveratrol does not mimic the positive effects of calorie restriction on lifespan in Microcebus murinus

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

Roles of Hippocampal Somatostatin Receptor Subtypes in Stress Response and Emotionality

Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Caloric restriction increases lifespan but affects brain integrity in grey mouse lemur primates

Moderate decline in select synaptic markers in the prefrontal cortex (BA9) of patients with Alzheimer’s disease at various cognitive stages

A novel Alzheimer disease locus located near the gene encoding tau protein

Promoting healthspan and lifespan with caloric restriction in primates

Parallel Loss of Hippocampal LTD and Cognitive Flexibility in a Genetic Model of Hyperdopaminergia

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