Nature Search

ANTXR1 blockade enhances cardiac function in preclinical models of heart failure

Boccella, Yu and colleagues reveal that the transmembrane protein ANTXR1 regulates post-infarction fibrotic remodeling, and its inhibition blocks collagen turnover and improves heart function.

Nicola Boccella
GuoJun Yu
Brad St. Croix
ResearchOpen Access02 Oct 2025
Nature Cardiovascular Research

P: 1-18
Deregulated DNA ADP-ribosylation impairs telomere replication

Telomeres are endogenous cellular targets of DNA ADP-ribosylation (DNA-ADPr). TARG1-regulated DNA-ADPr is coupled to lagging telomere DNA strand synthesis, and persistent DNA-ADPr, due to TARG1 deficiency, leads to telomere shortening and fragility.

Anne R. Wondisford
Junyeop Lee
Roderick J. O’Sullivan
ResearchOpen Access07 May 2024
Nature Structural & Molecular Biology

Volume: 31, P: 791-800
SALM4 negatively regulates NMDA receptor function and fear memory consolidation

To elucidate the role of synaptic cell adhesion-like molecule 4 (SALM4) in altering synaptic function in the context of fear memory, Lie at al performed behavioural and electrophysiological assessments of SALM4 knockout mice undergoing cued fear, spatial, and object-recognition memory tasks. They demonstrated that SALM4 suppresses heightened GluN2B-expressing NMDA receptor function specifically during fear memory consolidation.

Eunkyung Lie
Yeji Yeo
Eunjoon Kim
ResearchOpen Access29 Sept 2021
Communications Biology

Volume: 4, P: 1-17
Elfn1 recruits presynaptic mGluR7 in trans and its loss results in seizures

The transmembrane protein Elfn1 is implicated in synaptic plasticity. Tomioka et al. identify Elfn1 mutations in epilepsy and attention deficit hyperactivity disorder (ADHD) patients, and show that loss of Elfn1in mice results in seizures, ADHD-like behaviour and impaired development of excitatory synapses.

Naoko H. Tomioka
Hiroki Yasuda
Jun Aruga
Research22 Jul 2014
Nature Communications

Volume: 5, P: 1-16
SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3–LAR adhesion

Synaptic adhesion molecules regulate synapse development and function by both cis and trans-interactions. Here, Lie et al. show that postsynaptic SALM4 regulates excitatory synapse numbers by cisinhibition of the SALM3-LAR transynaptic interaction.

Eunkyung Lie
Ji Seung Ko
Eunjoon Kim
ResearchOpen Access02 Aug 2016
Nature Communications

Volume: 7, P: 1-15
Insufficient ascorbic acid intake during gestation induces abnormal cardiac dilation in fetal and neonatal SMP30/GNL knockout mice

Yuki Kishimoto
Takao Kanai
Akihito Ishigami
Research05 Feb 2013
Pediatric Research

Volume: 73, P: 578-584
Peli3 ablation ameliorates acetaminophen-induced liver injury through inhibition of GSK3β phosphorylation and mitochondrial translocation

Jaewon Lee
Jihoon Ha
Seok Hee Park
ResearchOpen Access01 Jun 2023
Experimental & Molecular Medicine

Volume: 55, P: 1218-1231
Adipocyte lysoplasmalogenase TMEM86A regulates plasmalogen homeostasis and protein kinase A-dependent energy metabolism

Dysregulation of plasmalogen metabolism in adipose tissue is associated with metabolic diseases. Here the authors characterize the role of adipocyte TMEM86A as a lysoplasmalogenase and show its deletion is protective against high fat diet induced metabolic disease, an effect that can be recapitulated by plasmenyl lysophosphatidylethanolamine 18:0 supplementation.

Yoon Keun Cho
Young Cheol Yoon
Yun-Hee Lee
ResearchOpen Access14 Jul 2022
Nature Communications

Volume: 13, P: 1-17
SMP30-mediated synthesis of vitamin C activates the liver PPARα/FGF21 axis to regulate thermogenesis in mice

Bonggi Lee
Hye Jin An
Hae Young Chung
ResearchOpen Access25 Nov 2022
Experimental & Molecular Medicine

Volume: 54, P: 2036-2046
ERdj5 protects goblet cells from endoplasmic reticulum stress-mediated apoptosis under inflammatory conditions

Hyunjin Jeong
Eun-Hye Hong
Hyun-Jeong Ko
ResearchOpen Access09 Feb 2023
Experimental & Molecular Medicine

Volume: 55, P: 401-412
Viral hijacking of the TENT4–ZCCHC14 complex protects viral RNAs via mixed tailing

Mixed tailing of hepatitis B virus and human cytomegalovirus transcripts via recruitment of the TENT4–ZCCHC14 complex by a common RNA element protects viral RNAs from degradation.

Dongwan Kim
Young-suk Lee
V. Narry Kim
Research25 May 2020
Nature Structural & Molecular Biology

Volume: 27, P: 581-588
Specification of neural circuit architecture shaped by context-dependent patterned LAR-RPTP microexons

LAR-RPTPs are presynaptic cell-adhesion proteins that regulate the synaptic properties. Here, LAR-RPTP microexon expression is profiled in region-, cell-type- and circuit-specific contexts and its physiological significance in encoding synaptic architecture is demonstrated.

Kyung Ah Han
Taek-Han Yoon
Jaewon Ko
ResearchOpen Access22 Feb 2024
Nature Communications

Volume: 15, P: 1-21
Author Correction: Specification of neural circuit architecture shaped by context-dependent patterned LAR-RPTP microexons

Kyung Ah Han
Taek-Han Yoon
Jaewon Ko
Amendments and CorrectionsOpen Access23 Jul 2024
Nature Communications

Volume: 15, P: 1
SLITRK2 variants associated with neurodevelopmental disorders impair excitatory synaptic function and cognition in mice

The protein SLITRK2 plays an important role in synaptic communication. This study identifies X-linked SLITRK2 variants that underlie neurodevelopmental disorders by impairing excitatory synapses.

Salima El Chehadeh
Kyung Ah Han
Ji Won Um
ResearchOpen Access15 Jul 2022
Nature Communications

Volume: 13, P: 1-19
Author Correction: Specification of neural circuit architecture shaped by context-dependent patterned LAR-RPTP microexons

Kyung Ah Han
Taek-Han Yoon
Jaewon Ko
Amendments and CorrectionsOpen Access07 Mar 2024
Nature Communications

Volume: 15, P: 1
Miniature Li⁺ solvation by symmetric molecular design for practical and safe Li-metal batteries

Developing safe, fast-recharging Li-metal batteries is challenging due to the need for stable, non-flammable electrolytes. This study presents an electrolyte design using miniature anion–Li⁺ solvation structures, achieving high conductivity, stable cycling and improved safety.

Jinha Jang
Chongzhen Wang
Jiheong Kang
Research06 Mar 2025
Nature Energy

Volume: 10, P: 502-512
A substrate-less nanomesh receptor with meta-learning for rapid hand task recognition

A nanomesh sensor that is directly printed on a person’s hand and is coupled with an unsupervised meta-learning framework can provide user-independent and data-efficient recognition of different hand tasks.

Kyun Kyu Kim
Min Kim
Zhenan Bao
Research28 Dec 2022
Nature Electronics

Volume: 6, P: 64-75
Conductive-bridge interlayer contacts for two-dimensional optoelectronic devices

A gold-embedded oxide interlayer can be used to create metal–interlayer–semiconductor contacts for two-dimensional materials that exhibit low series resistance and Fermi level depinning.

Jisu Jang
Jung Pyo Hong
Do Kyung Hwang
Research05 Feb 2025
Nature Electronics

Volume: 8, P: 298-308
Orchestration of synaptic functions by WAVE regulatory complex-mediated actin reorganization

Kyung Ah Han
Jaewon Ko
ReviewsOpen Access01 Jun 2023
Experimental & Molecular Medicine

Volume: 55, P: 1065-1075
Mechanosensory neurons control sweet sensing in Drosophila

How different sensory modalities interact to control feeding is poorly understood. Here, authors show that in Drosophila, activation of labellar mechanosensory neurons causes inhibition of sweet-sensing gustatory receptor neurons, as a result, Drosophilaprefer soft food at the expense of sweetness.

Yong Taek Jeong
Soo Min Oh
Seok Jun Moon
ResearchOpen Access19 Sept 2016
Nature Communications

Volume: 7, P: 1-9
Structural basis for LAR-RPTP/Slitrk complex-mediated synaptic adhesion

The presynaptic LAR-RPTPs interact with postsynaptic Slitrks and this contributes to regulating synapse formation. Here, the authors identified the minimal binding regions and determined the crystal structure of the resulting complex and performed functional analysis in cells to determine LAR-RPTP/Slitrk complex-mediated synapse formation.

Ji Won Um
Kee Hun Kim
Ho Min Kim
Research14 Nov 2014
Nature Communications

Volume: 5, P: 1-16
The role of charge recombination to triplet excitons in organic solar cells

A substantial pathway for energy loss in organic solar cells may be suppressed by engineering hybridization between non-fullerene acceptor triplet excitons and spin-triplet charge transfer excitons.

Alexander J. Gillett
Alberto Privitera
Richard H. Friend
Research29 Sept 2021
Nature

Volume: 597, P: 666-671
Block-building performance test using a virtual reality head-mounted display in children with intermittent exotropia

Seung Ah Chung
Jaewon Choi
Jeonggil Ko
Research01 Sept 2020
Eye

Volume: 35, P: 1758-1765
Discovery and functional characterization of canine PD-L1-targeted antibodies for evaluating antitumor efficacy in a canine osteosarcoma xenograft model

Min-young Song
Jaewon Cho
Hyun-Jeong Ko
ResearchOpen Access04 Mar 2025
Scientific Reports

Volume: 15, P: 1-11
Bioinspired dynamic colour change

Organisms have evolved diverse colouration strategies, including dynamic colour change, which enables their rapid adaptation to environmental stimuli. This Review discusses the recreation of bioinspired colouration and dynamic colour change mechanisms for applications in optics, sensors and biomedicine.

Seok Hwan Choi
Dohyung Kim
Seung Hwan Ko
Reviews27 Mar 2025
Nature Reviews Bioengineering

Volume: 3, P: 579-595
Lipid remodeling of adipose tissue in metabolic health and disease

Yoon Keun Cho
Sumin Lee
Yun-Hee Lee
ReviewsOpen Access01 Sept 2023
Experimental & Molecular Medicine

Volume: 55, P: 1955-1973
Gephyrin: a central GABAergic synapse organizer

Gayoung Choii
Jaewon Ko
ReviewsOpen Access17 Apr 2015
Experimental & Molecular Medicine

Volume: 47, P: e158
Association of cholecystectomy with short-term and long-term risks of depression and suicide

Jiwon Yu
Sangwoo Park
Sang min Park
ResearchOpen Access24 Feb 2025
Scientific Reports

Volume: 15, P: 1-10
Slitrk2 controls excitatory synapse development via PDZ-mediated protein interactions

Kyung Ah Han
Jinhu Kim
Ji Won Um
ResearchOpen Access19 Nov 2019
Scientific Reports

Volume: 9, P: 1-12
Nanowire-assisted freestanding liquid metal thin-film patterns for highly stretchable electrodes on 3D surfaces

Minwoo Kim
Chulmin Cho
Seung Hwan Ko
ResearchOpen Access26 Dec 2022
npj Flexible Electronics

Volume: 6, P: 1-8
Asymmetrical activation and asymmetrical weakness as two different mechanisms of adolescent idiopathic scoliosis

Yulhyun Park
Jin Young Ko
Ju Seok Ryu
ResearchOpen Access02 Sept 2021
Scientific Reports

Volume: 11, P: 1-9
Structural basis of SALM3 dimerization and synaptic adhesion complex formation with PTPσ

Sudeep Karki
Alexander V. Shkumatov
Tommi Kajander
ResearchOpen Access14 Jul 2020
Scientific Reports

Volume: 10, P: 1-13
IκBζ facilitates protective immunity against Salmonella infection via Th1 differentiation and IgG production

Jae-Hee Ahn
Jaewon Cho
Hyun-Jeong Ko
ResearchOpen Access10 Jun 2019
Scientific Reports

Volume: 9, P: 1-10
SALM5 trans-synaptically interacts with LAR-RPTPs in a splicing-dependent manner to regulate synapse development

Yeonsoo Choi
Jungyong Nam
Eunjoon Kim
ResearchOpen Access26 May 2016
Scientific Reports

Volume: 6, P: 1-12
Special Issue on Synapse Assembly, Neural Circuit Development, and Brain Disorders

Jaewon Ko
Eunjoon Kim
EditorialOpen Access09 Apr 2018
Experimental & Molecular Medicine

Volume: 50, P: 1-2
Robust estimation of bacterial cell count from optical density

In an inter-laboratory study, the authors compare the accuracy and performance of three optical density calibration protocols (colloidal silica, serial dilution of silica microspheres, and colony-forming unit (CFU) assay). They demonstrate that serial dilution of silica microspheres is the best of these tested protocols, allowing precise and robust calibration that is easily assessed for quality control and can also evaluate the effective linear range of an instrument.

Jacob Beal
Natalie G. Farny
Jiajie Zhou
ResearchOpen Access17 Sept 2020
Communications Biology

Volume: 3, P: 1-29
Author Correction: Robust estimation of bacterial cell count from optical density

Jacob Beal
Natalie G. Farny
Jiajie Zhou
Amendments and CorrectionsOpen Access27 Oct 2020
Communications Biology

Volume: 3, P: 1

Search

ANTXR1 blockade enhances cardiac function in preclinical models of heart failure

Deregulated DNA ADP-ribosylation impairs telomere replication

SALM4 negatively regulates NMDA receptor function and fear memory consolidation

Elfn1 recruits presynaptic mGluR7 in trans and its loss results in seizures

SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3–LAR adhesion

Insufficient ascorbic acid intake during gestation induces abnormal cardiac dilation in fetal and neonatal SMP30/GNL knockout mice

Peli3 ablation ameliorates acetaminophen-induced liver injury through inhibition of GSK3β phosphorylation and mitochondrial translocation

Adipocyte lysoplasmalogenase TMEM86A regulates plasmalogen homeostasis and protein kinase A-dependent energy metabolism

SMP30-mediated synthesis of vitamin C activates the liver PPARα/FGF21 axis to regulate thermogenesis in mice

ERdj5 protects goblet cells from endoplasmic reticulum stress-mediated apoptosis under inflammatory conditions

Viral hijacking of the TENT4–ZCCHC14 complex protects viral RNAs via mixed tailing

Specification of neural circuit architecture shaped by context-dependent patterned LAR-RPTP microexons

Author Correction: Specification of neural circuit architecture shaped by context-dependent patterned LAR-RPTP microexons

SLITRK2 variants associated with neurodevelopmental disorders impair excitatory synaptic function and cognition in mice

Author Correction: Specification of neural circuit architecture shaped by context-dependent patterned LAR-RPTP microexons

Miniature Li⁺ solvation by symmetric molecular design for practical and safe Li-metal batteries

A substrate-less nanomesh receptor with meta-learning for rapid hand task recognition

Conductive-bridge interlayer contacts for two-dimensional optoelectronic devices

Orchestration of synaptic functions by WAVE regulatory complex-mediated actin reorganization

Mechanosensory neurons control sweet sensing in Drosophila

Structural basis for LAR-RPTP/Slitrk complex-mediated synaptic adhesion

The role of charge recombination to triplet excitons in organic solar cells

Block-building performance test using a virtual reality head-mounted display in children with intermittent exotropia

Discovery and functional characterization of canine PD-L1-targeted antibodies for evaluating antitumor efficacy in a canine osteosarcoma xenograft model

Bioinspired dynamic colour change

Lipid remodeling of adipose tissue in metabolic health and disease

Gephyrin: a central GABAergic synapse organizer

Association of cholecystectomy with short-term and long-term risks of depression and suicide

Slitrk2 controls excitatory synapse development via PDZ-mediated protein interactions

Nanowire-assisted freestanding liquid metal thin-film patterns for highly stretchable electrodes on 3D surfaces

Asymmetrical activation and asymmetrical weakness as two different mechanisms of adolescent idiopathic scoliosis

Structural basis of SALM3 dimerization and synaptic adhesion complex formation with PTPσ

IκBζ facilitates protective immunity against Salmonella infection via Th1 differentiation and IgG production

SALM5 trans-synaptically interacts with LAR-RPTPs in a splicing-dependent manner to regulate synapse development

Special Issue on Synapse Assembly, Neural Circuit Development, and Brain Disorders

Robust estimation of bacterial cell count from optical density

Author Correction: Robust estimation of bacterial cell count from optical density

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