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Showing 1–2 of 2 results
Advanced filters: Author: Jailall Ramnauth Clear advanced filters

  • The authors show that DCAF1, a substrate receptor of CUL4 and EDVP E3 ligases, can be recruited by PROTACs to degrade the cancer drug target, WDR5. They also report the crystal structures of PROTAC ternary complexes that reveal a significant role for loops in DCAF1 substrate recognition, a potential mechanism behind the diverse substrate specificity of DCAF1.

    • Mark F. Mabanglo
    • Brian Wilson
    • Masoud Vedadi
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • OICR-41103 is a potent, selective probe targeting the DCAF1 WDR domain and displacing viral Vpr protein. It enables new opportunities in cancer research, antiviral therapy, and targeted protein degradation via PROTACs.

    • Serah W. Kimani
    • Mahmoud Noureldin
    • Levon Halabelian
    ResearchOpen Access
    Communications Biology
    Volume: 8, P: 1-12