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Showing 1–4 of 4 results

Advanced filters: Author: Jakob Schnabl Clear advanced filters

The nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation

Identification of SFiNX, a complex of Nxf2–Nxt1, a variant of the mRNA export receptor Nxf1–Nxt1 and the Piwi-associated protein Panoramix, demonstrates an RNA export independent role for Nxf2 in piRNA-guided cotranscriptional transposon silencing.

Julia Batki
Jakob Schnabl
Julius Brennecke
Research05 Aug 2019
Nature Structural & Molecular Biology

Volume: 26, P: 720-731
Panoramix SUMOylation on chromatin connects the piRNA pathway to the cellular heterochromatin machinery

Here, the authors provide mechanistic evidence for the piRNA pathway connection to the heterochromatin machinery in Drosophila.

Veselin I. Andreev
Changwei Yu
Julius Brennecke
Research16 Feb 2022
Nature Structural & Molecular Biology

Volume: 29, P: 130-142
Genetic and mechanistic diversity of piRNA 3′-end formation

Drosophila have two pathways for PIWI-interacting RNA (piRNA) 3′-end formation—depending on which pathway is used, piRNA biogenesis is directed towards either cytoplasmic or nuclear PIWI protein effectors, which balances post-transcriptional versus transcriptional transposon silencing.

Rippei Hayashi
Jakob Schnabl
Julius Brennecke
Research16 Nov 2016
Nature

Volume: 539, P: 588-592
Multiplexed detection of SARS-CoV-2 and other respiratory infections in high throughput by SARSeq

Massively parallel but cost-effective testing is essential to monitor the spread of pathogenic agents. Here the authors present SARSseq, which uses a dual indexing strategy in a multiplexed RT-PCR reaction to diagnose SARS-CoV-2 at scale.

Ramesh Yelagandula
Aleksandr Bykov
Ulrich Elling
ResearchOpen Access25 May 2021
Nature Communications

Volume: 12, P: 1-17