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Showing 1–2 of 2 results
Advanced filters: Author: Jakob T. Bullerjahn Clear advanced filters
  • Dynamic force spectroscopy is widely applied to probe molecular interactions by forcible bond breaking, but it currently lacks an analytical theory that spans the divide between experiment and simulation. Here, such a unified framework is developed and shown to be accurate for slow and fast loading.

    • Jakob T. Bullerjahn
    • Sebastian Sturm
    • Klaus Kroy
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-10
  • The function of transcription factors is conveyed through intrinsically disordered regions (IDRs) containing activation or repression domains, but the lack of quantitative structural ensemble models prevents their mechanistic decoding. Here, the authors use several methods to demonstrate that DNA binding can lead to complex changes in the IDR ensemble and accessibility on the example of the C-terminal IDR of pioneer factor Sox2.

    • Sveinn Bjarnason
    • Jordan A. P. McIvor
    • Pétur O. Heidarsson
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16