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Envelope glycoprotein mobility on HIV-1 particles depends on the virus maturation state

To become infectious, HIV-1 particles undergo a maturation process involving the clustering of envelope glycoprotein Env. Here, Chojnacki et al. employ super-resolution STED-FCS microscopy to study dynamics of Env molecules on HIV-1 particles and show that Env undergoes a maturation-induced increase in mobility.

Jakub Chojnacki
Dominic Waithe
Christian Eggeling
ResearchOpen Access15 Sept 2017
Nature Communications

Volume: 8, P: 1-10
Molecular recognition of the native HIV-1 MPER revealed by STED microscopy of single virions

The Membrane-Proximal External Region (MPER) of the HIV Env gp41 subunit is a target for broadly neutralizing antibodies. Here, the authors apply super-resolution stimulated emission depletion (STED) microscopy on single virions and provide insights into how the MPER epitope is recognized.

Pablo Carravilla
Jakub Chojnacki
José L. Nieva
ResearchOpen Access08 Jan 2019
Nature Communications

Volume: 10, P: 1-11
Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence

Extracellular vesicles (EVs) in plasma can affect pathogenesis of parasites, but details remain unclear. Here, Toda et al. characterize plasma-derived EVs from Plasmodium vivax patients and show that PvEVs are preferentially taken up by human spleen fibroblasts, facilitating parasite cytoadherence.

Haruka Toda
Miriam Diaz-Varela
Hernando A. del Portillo
ResearchOpen Access02 Jun 2020
Nature Communications

Volume: 11, P: 1-12
Anti-Siglec-1 antibodies block Ebola viral uptake and decrease cytoplasmic viral entry

The sialic acid-binding Ig-like lectin 1 (Siglec-1, also known as CD169) plays a more prominent role than the C-type lectin dendritic cell-specific intercellular adhesion molecule-3-Grabbing non-integrin in mediating Ebola virus entry into activated dendritic cells, and anti-Siglec-1 monoclonal antibodies can antagonize this process.

Daniel Perez-Zsolt
Itziar Erkizia
Nuria Izquierdo-Useros
Research03 Jun 2019
Nature Microbiology

Volume: 4, P: 1558-1570
Immune mobilising T cell receptors redirect polyclonal CD8⁺ T cells in chronic HIV infection to form immunological synapses

Zoë Wallace
Jakub Kopycinski
Lucy Dorrell
ResearchOpen Access01 Nov 2022
Scientific Reports

Volume: 12, P: 1-13
Ultrafast, temporally stochastic STED nanoscopy of millisecond dynamics

Temporally stochastic STED nanoscopy with electro-optical deflector–based scanning allows ultrafast super-resolution imaging. The method was used to monitor vesicles and viruses moving at ~2 μm/s with no motion blur.

Jale Schneider
Jasmin Zahn
Stefan W Hell
Research27 Jul 2015
Nature Methods

Volume: 12, P: 827-830
Author Correction to: SARS-CoV-2 interaction with Siglec-1 mediates trans-infection by dendritic cells

Daniel Perez-Zsolt
Jordana Muñoz-Basagoiti
Nuria Izquierdo-Useros
Amendments and CorrectionsOpen Access11 Jul 2022
Cellular & Molecular Immunology

Volume: 19, P: 965-966
SARS-CoV-2 interaction with Siglec-1 mediates trans-infection by dendritic cells

Daniel Perez-Zsolt
Jordana Muñoz-Basagoiti
Nuria Izquierdo-Useros
CorrespondenceOpen Access15 Nov 2021
Cellular & Molecular Immunology

Volume: 18, P: 2676-2678

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Envelope glycoprotein mobility on HIV-1 particles depends on the virus maturation state

Molecular recognition of the native HIV-1 MPER revealed by STED microscopy of single virions

Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence

Anti-Siglec-1 antibodies block Ebola viral uptake and decrease cytoplasmic viral entry

Immune mobilising T cell receptors redirect polyclonal CD8⁺ T cells in chronic HIV infection to form immunological synapses

Ultrafast, temporally stochastic STED nanoscopy of millisecond dynamics

Author Correction to: SARS-CoV-2 interaction with Siglec-1 mediates trans-infection by dendritic cells

SARS-CoV-2 interaction with Siglec-1 mediates trans-infection by dendritic cells

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