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Showing 1–2 of 2 results
Advanced filters: Author: Jakub Luptak Clear advanced filters

  • TRIM21 mediates intracellular antibody immunity and is exploited for targeted protein degradation using Trim-Away technology. Here, the authors dissect the ubiquitination requirements for Trim-Away, providing an explanation for how TRIM21 can target diverse substrates for degradation.

    • Leo Kiss
    • Tyler Rhinesmith
    • Leo C. James
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • The mechanism behind Trim-Away, a protein-depletion approach using E3 ligase, TRIM21 and an antibody against the target, is now clarified, allowing expansion of the toolbox.

    • Jingwei Zeng
    • Ana Filipa Santos
    • Leo C. James
    Research
    Nature Structural & Molecular Biology
    Volume: 28, P: 278-289