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MNase titration reveals differences between nucleosome occupancy and chromatin accessibility

Nucleosome positioning and chromatin accessibility are important contributors to the regulation of gene expression. Here the authors describe a method that allows the simultaneous measurement of nucleosome occupancy and chromatin accessibility in the same assay, revealing new features of chromatin organization linked to gene regulation.

Jakub Mieczkowski
April Cook
Michael Y. Tolstorukov
ResearchOpen Access06 May 2016
Nature Communications

Volume: 7, P: 1-11
EGFR/FOXO3a/BIM signaling pathway determines chemosensitivity of BMP4-differentiated glioma stem cells to temozolomide

Iwona Anna Ciechomska
Bartlomiej Gielniewski
Jakub Mieczkowski
ResearchOpen Access12 Aug 2020
Experimental & Molecular Medicine

Volume: 52, P: 1326-1340
Author Correction: Mapping chromatin accessibility and active regulatory elements reveals pathological mechanisms in human gliomas

Karolina Stępniak
Magdalena A. Machnicka
Bartek Wilczyński
Amendments and CorrectionsOpen Access06 Dec 2021
Nature Communications

Volume: 12, P: 1
Mapping chromatin accessibility and active regulatory elements reveals pathological mechanisms in human gliomas

Gliomas are tumors often associated with epigenetics-related gene deregulation. Here the authors reveal an atlas of active enhancers and promoters in benign and malignant gliomas by performing whole-genome mapping of chromatin accessibility, histone modifications, DNA methylation patterns and transcriptome analysis simultaneously in multiple tumor samples.

Karolina Stępniak
Magdalena A. Machnicka
Bartek Wilczyński
ResearchOpen Access15 Jun 2021
Nature Communications

Volume: 12, P: 1-17
Single-cell RNA sequencing reveals functional heterogeneity of glioma-associated brain macrophages

Microglia and peripheral myeloid cells are critically involved in the immunopathology of glioblastoma. Here the authors present single-cell sequencing data that assesses the phenotypic composition of CD11b + myeloid cells from a murine model of glioblastoma and suggest enhanced MHCII transcription which they additionally report from human cases of glioblastoma.

Natalia Ochocka
Pawel Segit
Bozena Kaminska
ResearchOpen Access19 Feb 2021
Nature Communications

Volume: 12, P: 1-14
Personalized health risk assessment based on single-cell RNA sequencing analysis of a male with 45, X/48, XYYY karyotype

Magdalena Koczkowska
Marcin Jąkalski
Arkadiusz Piotrowski
ResearchOpen Access02 Dec 2022
Scientific Reports

Volume: 12, P: 1-7
A second space age spanning omics, platforms and medicine across orbits

The current ‘second space age’ has enabled multiple studies on the effects of spaceflight on human physiology and health, which are contributing to the development of measures that will be needed to maintain astronaut health in future space missions.

Christopher E. Mason
James Green
Afshin Beheshti
Reviews11 Jun 2024
Nature

Volume: 632, P: 995-1008
DMRTA2 supports glioma stem-cell mediated neovascularization in glioblastoma

Marta Maleszewska
Kamil Wojnicki
Bozena Kaminska
ResearchOpen Access20 Mar 2024
Cell Death & Disease

Volume: 15, P: 1-10
SMARCB1-mediated SWI/SNF complex function is essential for enhancer regulation

Charles Roberts, Peter Park, Bradley Bernstein and colleagues examine the consequences of SMARCB1 loss on enhancer landscapes in human rhabdoid tumors. They show that SMARCB1 is essential for the integrity and abundance of SWI/SNF complexes and facilitates their targeting to appropriate enhancers.

Xiaofeng Wang
Ryan S Lee
Charles W M Roberts
Research12 Dec 2016
Nature Genetics

Volume: 49, P: 289-295
Antidepressant-induced membrane trafficking regulates blood-brain barrier permeability

Wenjia Du
Huanhuan Chen
Oleg O. Glebov
ResearchOpen Access30 May 2024
Molecular Psychiatry

Volume: 29, P: 3590-3598
Loss of Y in regulatory T lymphocytes in the tumor micro-environment of primary colorectal cancers and liver metastases

Magdalena Wójcik
Ulana Juhas
Jan P. Dumanski
ResearchOpen Access24 Apr 2024
Scientific Reports

Volume: 14, P: 1-12
Chromosomal positioning and epigenetic architecture influence DNA methylation patterns triggered by galactic cosmic radiation

Adrian Perdyan
Marcin Jąkalski
Jakub Mieczkowski
ResearchOpen Access15 Jan 2024
Scientific Reports

Volume: 14, P: 1-13
Search for novel STAT3-dependent genes reveals SERPINA3 as a new STAT3 target that regulates invasion of human melanoma cells

Transcription factor STAT3 constitutively activated in cancer promotes tumor progression. The authors detected activated STAT3 in human metastatic melanoma cells and identified new STAT3 targets. STAT3 regulates a discrete set of genes in melanoma cells and its knockdown impairs cell migration and invasion via regulation of its transcriptional target SERPINA3.

Dorota W. Kulesza
Kavita Ramji
Bozena Kaminska
Research05 Jul 2019
Laboratory Investigation

Volume: 99, P: 1607-1621
Immune microenvironment of experimental rat C6 gliomas resembles human glioblastomas

Anna Gieryng
Dominika Pszczolkowska
Bozena Kaminska
ResearchOpen Access14 Dec 2017
Scientific Reports

Volume: 7, P: 1-14

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